Wastewater-based epidemiology approach to assess population exposure to pesticides: a review of a pesticide pharmacokinetic dataset

Devault, Damien A.; Karolak, Sara

doi:10.1007/s11356-019-07521-9

Cited by 32 publications

(13 citation statements)

References 53 publications

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“…WBE can be used for the environmental analysis of pesticide biomarkers (triazines, pyrethroids, organochlorines, and organophosphates) as a low-cost complementary biomonitoring tool for assessing population-wide exposure [ 22 ]. An expanded WBE pharmacokinetic dataset has been developed describing excretion rates and stability descriptions of 2,4-D, aldrin, carbaryl, chlorobenzilate, dieldrin, diquat, ethion, glufosinate, glyphosate, folpet, malathion, parathion, penconazole, and tebuconazole [ 23 ]. There has been a recent development of a sensitive and accurate method for the rapid determination of selected insecticides and herbicides in tap and wastewater samples using vortex-assisted, solvent-based liquid-phase microextraction prior to determination by gas chromatography-mass spectrometry [ 24 ].…”

Section: Wastewater Sampling Techniques and Resolutionmentioning

confidence: 99%

“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring

Erickson

Endo²,

Duvallet³

et al. 2021

J. Med. Toxicol.

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During the current global COVID-19 pandemic and opioid epidemic, wastewater-based epidemiology (WBE) has emerged as a powerful tool for monitoring public health trends by analysis of biomarkers including drugs, chemicals, and pathogens. Wastewater surveillance downstream at wastewater treatment plants provides large-scale population and regional-scale aggregation while upstream surveillance monitors locations at the neighborhood level with more precise geographic analysis. WBE can provide insights into dynamic drug consumption trends as well as environmental and toxicological contaminants. Applications of WBE include monitoring policy changes with cannabinoid legalization, tracking emerging illicit drugs, and early warning systems for potent fentanyl analogues along with the resurging wave of stimulants (e.g., methamphetamine, cocaine). Beyond drug consumption, WBE can also be used to monitor pharmaceuticals and their metabolites, including antidepressants and antipsychotics. In this manuscript, we describe the basic tenets and techniques of WBE, review its current application among drugs of abuse, and propose methods to scale and develop both monitoring and early warning systems with respect to measurement of illicit drugs and pharmaceuticals. We propose new frontiers in toxicological research with wastewater surveillance including assessment of medication assisted treatment of opioid use disorder (e.g., buprenorphine, methadone) in the context of other social burdens like COVID-19 disease.

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Section: Wastewater Sampling Techniques and Resolutionmentioning

confidence: 99%

“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring

Erickson

Endo²,

Duvallet³

et al. 2021

J. Med. Toxicol.

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“…One of the areas that is increasing is the evaluation of human exposure [ 20 , 26 ] reflected on a high number of studies regarding exposure to pesticides [ [73] , [74] , [75] , [76] ], mycotoxins [ 77 ], bisphenol A and its analogues [ 78 ], personal care and household products [ 26 ], phthalates [ 79 ], organophosphorus flame retardants and plasticizers [ 14 , 80 ]. Some of these studies are highly useful reviews of the known pharmacokinetics datasets [ 26 , 73 ] that help in the identification of proper biomarkers and highlights the limitation to overcome in this type of studies that is share with consumption studies —many of the biomarkers used are not exclusive to humans and can therefore sometimes come from other sources, making it difficult to assess exposure.…”

Section: Classification and Characteristics Of The Different Approaches To Identify Biomarkersmentioning

confidence: 99%

Identification of biomarkers in wastewater-based epidemiology: Main approaches and analytical methods

Picó

Barceló

2021

TrAC Trends in Analytical Chemistry

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“…Wastewater-based epidemiology (WBE) is a recent approach to human biomonitoring based on the measurement of human biomarkers in urban wastewater and the subsequent calculation using the concentrations of biomarkers detected to determine population exposure or consumption [ 93 , 94 ]. This method assesses spatial and temporal trends and responses to specific events within a study catchment [ 95 ].…”

Section: Direct Approachesmentioning

confidence: 99%

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

2021

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Background: Pesticide residues are a threat to the health of the global population, not only to farmers, applicators, and other pesticide professionals. Humans are exposed through various routes such as food, skin, and inhalation. This study summarizes the different methods to assess and/or estimate human exposure to pesticide residues of the global population. Methods: A systematic search was carried out on Scopus and web of science databases of studies on human exposure to pesticide residues since 2019. Results: The methods to estimate human health risk can be categorized as direct (determining the exposure through specific biomarkers in human matrices) or indirect (determining the levels in the environment and food and estimating the occurrence). The role that analytical techniques play was analyzed. In both cases, the application of generic solvent extraction and solid-phase extraction (SPE) clean-up, followed by liquid or gas chromatography coupled to mass spectrometry, is decisive. Advances within the analytical techniques have played an unquestionable role. Conclusions: All these studies have contributed to an important advance in the knowledge of analytical techniques for the detection of pesticide levels and the subsequent assessment of nonoccupational human exposure.

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Wastewater-based epidemiology approach to assess population exposure to pesticides: a review of a pesticide pharmacokinetic dataset

Cited by 32 publications

References 53 publications

“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring

“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring

Identification of biomarkers in wastewater-based epidemiology: Main approaches and analytical methods

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

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