Water absorption characteristics and cytotoxic and biological evaluation of bone cements formulated with a novel activator

Deb, Sanjukta; Silvio, L. Di; Vázquez, Blanca; Román, Julio San

doi:10.1002/(sici)1097-4636(1999)48:5<719::aid-jbm18>3.0.co;2-h

Cited by 20 publications

(12 citation statements)

References 11 publications

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“…The bone cement specimens were maintained in cell culture medium for 7 days to enable any leachants that may elute during the early stages. It has been observed from earlier studies on diffusion that most leachables are eluted within this period and subsequently only minute amounts of leachables are extracted 15. The eluants from the bone cement specimens were then exposed to HOS cells for 48 h that would display any cytotoxic effects due to the eluants from the cements.…”

Section: Discussionmentioning

confidence: 99%

PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties

et al. 2007

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An iodinated quaternary amine dimethacrylate monomer was synthesized and incorporated as a comonomer in acrylic bone cements. Bone cement is used in orthopaedic surgery and imparting antibacterial properties to the cement can be beneficial in the lowering of bacterial infection post surgery. PMMA based bone cements were modified by copolymerising the monomer methylmethacrylate (MMA) with a quaternary amine dimethacrylate by using the redox initiator activator system as used for curing commercial bone cements. The cements were prepared using the commercial PMMA bone cement CMW and the liquid component was modified with the amine to render antimicrobial properties to the cement. The physical, mechanical, and antimicrobial properties of the modified cements were evaluated; in addition, the viability of the cement to function as a orthopaedic cement was also established, especially with an advantage of it being radiopaque, due to the inclusion of the iodine containing quaternary amine. The cytotoxicity of the modified cements were tested using a human cell model and the results indicated that the cells remained metabolically active and proliferated when placed in direct contact with the experimental cement specimens. The cements and their eluants did not evoke any cytotoxic response.

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Section: Discussionmentioning

confidence: 99%

PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties

et al. 2007

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“…Investigating the water absorption of the acrylic bone cements is very important for orthopedic applications, as the absorbed water influences the mechanical and biological properties of the bone cement 12, 15, 32, 41–44. Additionally, water absorption may induce hydrolysis of some (active) ingredients from the acrylic bone cement, which negatively influences the mechanical and biological properties.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, water absorption may induce hydrolysis of some (active) ingredients from the acrylic bone cement, which negatively influences the mechanical and biological properties. To a certain extent, water uptake may become beneficial for some medical applications, as for the dental filling materials, since the water swelling may compensate for polymerization shrinkage 41–44…”

Section: Resultsmentioning

confidence: 99%

“…Cement shrinkage associated to the setting reaction comes with the transformation of a viscous material into hardened one, which generates an increase in density, and a volume decrease 51. Quantitatively, the polymerization shrinkage (Sh) was determined as following42: The experimental shrinkage (Sh exp ) was determined via density measurements (experimental, i.e., apparent density, ρ exp ), while for the theoretical shrinkage (Sh theor ) the following relation was considered21, 42, 52: where 22.5 is the volume change per mole of methacrylate groups (CC) in MMA (cm 3 /mol) when MMA is polymerized 53, 54. DC max is the fractional degree of conversion, f i is the functionality of monomer (i), x i is the mole fraction of monomer (i), M mi is the molecular mass of monomer (i), and ρ mix is the density of the monomer mixture.…”

Section: Resultsmentioning

confidence: 99%

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Radiopaque acrylic bone cements with bromine‐containing monomer

Rusu¹,

Ibănescu²,

Ichim³

et al. 2008

J of Applied Polymer Sci

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One important issue for the acrylic bone cements concerns the radiopacity, which may be achieved by different ways. In this work, a new bromine-containing acrylic monomer, the 2-(2-bromopropionyloxy) propyl methacrylate (BPPM), was synthesized and proposed to be used for providing radiopaque bone cements. Different acrylic bone cements were realized by partially replacing the methyl methacrylate (MMA) monomer phase with 5-20% w/w of BPPM-comonomer. The effect of this comonomer on the curing parameters of acrylic bone cements, on their thermal and rheological properties, water absorption, density, contact angle, compression tests, and radiopacity was studied. It appears that the presence of BPPM does provide radiopacity, improves the curing parameters by decreasing the maximum curing temperature and increasing the setting time. The new BPPM-acrylic bone cements exhibit lower glass transition temperature and better thermal stability when compared with the classical radiolucent acrylic cements. Rheological measurements have shown that 10-20% w/w of BPPM in the liquid phase of acrylic bone cement formulations increase its flexibility, and may also induce a slight crosslinking reaction during the curing phase. BPPM-modified acrylic bone cements present lower polymerization shrinkage and higher compression strength, and similar water uptake, porosity, and water contact angle as the radiolucent PMMA-cements.

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“…PMMA bone cements provide a multitude of advantageous characteristics such as high strength, bioinertness, biocompatibility and long-term clinical history [1,2]. However, drawbacks related to acrylic cements are typically associated to high curing temperatures, high residual monomer, shrinkage, and poor interdigitation with bone.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Injectable Brushite Filled-Poly (Methyl Methacrylate) Bone Cement

et al. 2014

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Powder-liquid poly (methyl methacrylate) (PMMA) bone cements are widely utilized for augmentation of bone fractures and fixation of orthopedic implants. These cements typically have an abundance of beneficial qualities, however their lack of bioactivity allows for continued development. To enhance osseointegration and bioactivity, calcium phosphate cements prepared with hydroxyapatite, brushite or tricalcium phosphates have been introduced with rather unsuccessful results due to increased cement viscosity, poor handling and reduced mechanical performance. This has limited the use of such cements in applications requiring delivery through small cannulas and in load bearing. The goal of this study is to design an alternative cement system that can better accommodate calcium-phosphate additives while preserving cement rheological properties and performance. In the present work, a number of brushite-filled two-solution bone cements were prepared and characterized by studying their complex viscosity-versus-test frequency, extrusion stress, clumping tendency during injection through a syringe, extent of fill of a machined void in cortical bone analog specimens, and compressive strength. The addition of brushite into the two-solution cement formulations investigated did not affect the pseudoplastic behavior and handling properties of the materials as demonstrated by rheological experiments. Extrusion stress was observed to vary with brushite concentration with values lower or in the range of control PMMA-based cements. The materials were observed to completely fill pre-formed voids in bone analog specimens. Cement compressive strength was observed to decrease with increasing concentration of fillers; however, the materials exhibited high enough strength for consideration in load bearing applications. The results indicated that partially substituting the PMMA phase of the two-solution cement with brushite at a 40% by mass concentration provided the best combination of the properties investigated. This alternative material may find applications in systems requiring highly injectable and viscous cements such as in the treatment of spinal fractures and bone defects.

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Water absorption characteristics and cytotoxic and biological evaluation of bone cements formulated with a novel activator

Cited by 20 publications

References 11 publications

PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties

PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties

Radiopaque acrylic bone cements with bromine‐containing monomer

Preparation and Characterization of Injectable Brushite Filled-Poly (Methyl Methacrylate) Bone Cement

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