Water deprivation affects serotoninergic system and glycoprotein secretion in the sub-commissural organ of a desert rodent Meriones shawi

Elgot, Abdeljalil; Ahboucha, Samir; Bouyatas, My Mustapha; Fèvre‐Montange, Michelle; Gamrani, Halima

doi:10.1016/j.neulet.2009.08.058

Cited by 21 publications

(17 citation statements)

References 30 publications

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“…Serotonin is important in regulating water balance and electrolyte homeostasis (Johnson and Thunhorst, 1997; Elgot et al, 2009; Fonseca et al, 2009). The body normally keeps serum concentrations of sodium within 135–145 mEq/L, and hyponatremia occurs when levels fall below 130 mEq/L (Moret et al, 2009).…”

Section: Cerebrovascular Eventsmentioning

confidence: 99%

Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good

Andrews¹,

Thomson²,

Amstadter³

et al. 2012

Front. Psychology

106

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Antidepressant medications are the first-line treatment for people meeting current diagnostic criteria for major depressive disorder. Most antidepressants are designed to perturb the mechanisms that regulate the neurotransmitter serotonin – an evolutionarily ancient biochemical found in plants, animals, and fungi. Many adaptive processes evolved to be regulated by serotonin, including emotion, development, neuronal growth and death, platelet activation and the clotting process, attention, electrolyte balance, and reproduction. It is a principle of evolutionary medicine that the disruption of evolved adaptations will degrade biological functioning. Because serotonin regulates many adaptive processes, antidepressants could have many adverse health effects. For instance, while antidepressants are modestly effective in reducing depressive symptoms, they increase the brain’s susceptibility to future episodes after they have been discontinued. Contrary to a widely held belief in psychiatry, studies that purport to show that antidepressants promote neurogenesis are flawed because they all use a method that cannot, by itself, distinguish between neurogenesis and neuronal death. In fact, antidepressants cause neuronal damage and mature neurons to revert to an immature state, both of which may explain why antidepressants also cause neurons to undergo apoptosis (programmed death). Antidepressants can also cause developmental problems, they have adverse effects on sexual and romantic life, and they increase the risk of hyponatremia (low sodium in the blood plasma), bleeding, stroke, and death in the elderly. Our review supports the conclusion that antidepressants generally do more harm than good by disrupting a number of adaptive processes regulated by serotonin. However, there may be specific conditions for which their use is warranted (e.g., cancer, recovery from stroke). We conclude that altered informed consent practices and greater caution in the prescription of antidepressants are warranted.

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Section: Cerebrovascular Eventsmentioning

confidence: 99%

Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good

Andrews¹,

Thomson²,

Amstadter³

et al. 2012

Front. Psychology

106

View full text Add to dashboard Cite

show abstract

“…1,2 Among these small mammals, Meriones shawi (Muridae) has a particular ability to support prolonged dehydration for several months by obtaining preformed water from food and metabolic water. 3,4 However, in the last decades, the continuous anthropogenic pressure exerted on the environment has constituted a real environmental problem and might have a negative impact on the quality of human life. 5,6 Therefore, environmental awareness has grown dramatically and several nations are taking the lead in implementing laws related to the environment.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary cadmium exposure on osmoregulation and urine concentration mechanisms of the semi-desert rodent Meriones shawi

et al. 2012

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Contamination by cadmium in the environment is of great concern because of its toxicity and threats to human and animal health. The current study was conducted to investigate the effects of a cadmium contaminated diet on the osmoregulation and urine concentration mechanisms of the semi-desert rodent Meriones shawi and eventual accumulation of this metal in vital organs such as the kidneys, which are directly implicated in water regulation. Originally, we used Differential Pulse Anodic Stripping Voltammetry (DPASV) to avoid the matrix interference due to the highly organic content in the biological samples. Our results show that Meriones shawi successfully maintained a homeostasis state and presented a special adaptation to regulate urine volume during cadmium exposure by decreasing diuresis and increasing urinary osmolality. The plasma osmolality and hematocrit remained constant throughout the experiment. The stripping signals of cadmium are linear up to 0.3-100 μg L(-1) range, with a detection limit of 0.28 μg L(-1). The DPASV technique was useful for easy, fast, selective and sensitive determination of Cd, which permits working at cellular concentration. This gives us more information about the chemical form in which Cd is introduced into the organ, as well as the intracellular Cd quantities. This study has potential importance if this valuable novel animal model, imitating human and animal environmental chronic exposure to Cd, could serve as an appropriate terrestrial biomonitor for Cd contaminated sites. These results are encouraging in the context of developing a low-cost and fast technology for the detection of pollutants and for studying the impairment caused by their effects.

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“…Many homeostatic mechanisms and physiological adaptations to deserts have been characterized in several rodents like Gerboa, Pocket mice, Meriones, Jerbils (Ghobrial and Nour 1975 ; Baddouri et al 1987 ; Baddouri and Quyou 1991 ; Ouali and Bensalem 1996 ). Interestingly, Meriones are characterized by their resistance to long periods of thirst and have a particular ability to support prolonged dehydration for periods up to three months (Laalaoui et al 2001 ; Elgot et al 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus

Boumansour

Benhafri

Guillon

et al. 2021

Animal Cells and Systems

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In mammals, plasmatic osmolality needs to be stable, and it is highly related to the hydric state of the animals which depends on the activity of the hypothalamic neurohypophysial system and more particularly by vasopressin secretion. Meriones, a desert rodent, can survive even without drinking for more than one month. The mechanism(s) by which they survive under these conditions remains poorly understood. In this study, we examine the water's deprivation consequences on the: (1) anatomy, morphology, and physiology of the hypothalamic supraoptic nucleus, (2) body mass and plasma electrolytes changes in male desert rodents 'Meriones libycus' subjected to water deprivation for 30 days. The effect of water deprivation was evaluated on the structural and cellular organization of the supraoptic nucleus by morphological observations and immunohistochemical approaches, allowing the labeling of AVP but also oxytocin. Our finding demonstrated that upon water deprivation (1) the body weight decreased and reached a plateau after a month of water restriction. (2) The plasmatic osmolality began to decrease and return to values similar to control animals at day 30. (3) The SON, both in hydrated and water-deprived animals, is highly developed.(4) The AVP labeling in the SON increased upon dehydration at variance with OT. These changes observed in body mass and plasma osmolality reveal an important adaptive process of male Meriones in response to prolonged water deprivation. Overall, this animal represents an interesting model for the study of water body homeostasis and the mechanisms underlying the survival of desert rodents to xeric environments.

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Water deprivation affects serotoninergic system and glycoprotein secretion in the sub-commissural organ of a desert rodent Meriones shawi

Cited by 21 publications

References 30 publications

Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good

Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good

Effects of dietary cadmium exposure on osmoregulation and urine concentration mechanisms of the semi-desert rodent Meriones shawi

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus

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