Water-dispersible ascorbic-acid-coated magnetite nanoparticles for contrast enhancement in MRI

Abstract

Superparamagnetic iron oxide nanoparticles of size *5 nm surface functionalized with ascorbic acid (vitamin C) form a stable dispersion in water with a hydrodynamic size of *30 nm. The anti-oxidant property of ascorbic acid is retained after capping, as evidenced from the capability of converting methylene blue to its reduced leuco form. NMR relaxivity studies show that the ascorbic-acid-coated superparamagnetic iron oxide aqueous nanofluid is suitable as a contrast enhancement agent for MRI applications, coupled with the excellent biocompatibility and medicinal values of ascorbic acid.

Green Synthesis of Iron Nanoparticles and Their Environmental Applications and Implications

“…In one study, superparamagnetic iron oxide nanoparticles were coated and further functionalised by using ascorbic acid (Vitamin C) to form a stable dispersion for medical application. The transmission electron microscope (TEM) image of the coated nanoparticles revealed that particles were spherical in shape with an average particle size of 5 nm [13]. …”

Surface Modification of ZrO2 Nanoparticles with Biosafe Coupling Agents, Preparation of Poly(vinyl pyrrolidone) Nanocomposites: Optical, Thermal, and Morphological Studies

“…1d, pure VC has characteristic peaks at the range 3215-3520 cm À1 corresponding to different hydroxyl groups, absorption bands at 1750 cm À1 related to the stretching vibrations of the C=O of the five membered lactone ring, and 1665 cm À1 which corresponds to the C=C stretching band. 32 In the CA spectrum (Fig. 1e), the presence of band at 3300 and 2940 cm À1 are due to the non-dissociated OH groups of CA and CH 2 stretching group.…”

A Benign and Simple Strategy for Surface Modification of Al2O3 Nanoparticles with Citric Acid and L(+)‐Ascorbic Acid and Its Application for the Preparation of Novel Poly(vinyl chloride) Nanocomposite Films

“…The absorption at 1665 cm −1 confirmed the existence of the C=C stretching band. 25 The FT-IR spectrum of modified Al 2 O 3 NPs (Fig. 1a) displays new characteristic peaks.…”

“…24 It has two ionizable forms with pKa 1 4.2 and pKa 2 11.6 [pH = pKa -log [(AH/A − )] and exist as ascorbate (AsCH − ) at physiological pH. 25 Vitamin C is essential for life and is a powerful water-soluble antioxidant, which cannot be stored by the body except in insignificant amounts. 26,27 So it must be replenished daily with the diet primarily containing fruits and vegetables.…”