Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro

Kim, Gi‐Young; Ko, Woo-Shin; Lee, Jaeyoon; Lee, Jeong-Ok; Ryu, Chung Ho; Choi, Byung Tae; Park, Yeong‐Min; Jeong, Young-Ki; Lee, Kyeong‐Jun; Choi, Kwang-Sik; Heo, Moon‐Soo; Choi, Yung Hyun

doi:10.1248/bpb.29.354

Cited by 36 publications

(22 citation statements)

References 31 publications

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“…CM also contains higher concentration of cordycepin than CS (Yu et al, 2006). Cordycepin from C. militaris has been reported to have acute anti-inflammatory, anti-nociceptive, anti-angiogenesis and immunoregulatory activities (Kim et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats

Hong¹,

Choi²,

Woo³

et al. 2011

International Journal of Industrial Entomology

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Some of men have been suffered from the insufficient secretion of testosterone causing by physical factors, social and psychological factors. Testosterone is an essential steroid hormone controlling male reproductive function. Alternative medicines in plants, fungi, and insects have been studied to enhance sexuality. Cordyceps species including Cordyceps sinensis (CS) and C. militaris(CM) has been used as for the enhancement of sexual functionfor hundreds of years in Far East Asian. In the present study, we determined the effect of fruiting bodies of C. militaris which cultured on bee drone medium (CMD) and brown rice medium (CMB) on testosterone concentration in Sprague-Dawley rats. Eighteen rats per group were housed to regular diet or diet supplemented with CMB and CDD, respectively for 4 weeks. Serum was collected from 6 rats per group. Results showed that changes of the body weight, food and water intake of the rats were not observed in this study. However, both CMB and CDD increased the serum testosterone concentration in rats. Furthermore, CMD significantly stimulated testosterone production (p <0.05) compared to the control. Hence, it suggests that C. militaris fruiting bodymight be developed as a complementary medicine to improve sexual hormones.

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Section: Introductionmentioning

confidence: 99%

Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats

Hong¹,

Choi²,

Woo³

et al. 2011

International Journal of Industrial Entomology

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“…These mushroom extracts induce phenotypic and functional maturation of dendritic cells, tumoricidal activity in macrophages, and augmentation of natural killer cell activity [Sorimachi et al, 2001;Kodama et al, 2005;Kim et al, 2006]. It has also been shown that oral administration of mushroom extracts has an anti-inflammatory effect [Bernardshaw et al, 2006] and decreases IgE levels through modulation of the Th1/Th2 balance [Inagaki et al, 2005;Lim et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Induction of cross‐protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia

Ichinohe

Ainai

Nakamura

et al. 2009

Journal of Medical Virology

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The identification of a safe and effective adjuvant that is able to enhance mucosal immune responses is necessary for the development of an efficient inactivated intranasal influenza vaccine. The present study demonstrated the effectiveness of extracts of mycelia derived from edible mushrooms as adjuvants for intranasal influenza vaccine. The adjuvant effect of extracts of mycelia was examined by intranasal co-administration of the extracts and inactivated A/PR8 (H1N1) influenza virus hemagglutinin (HA) vaccine in BALB/c mice. The inactivated vaccine in combination with mycelial extracts induced a high anti-A/PR8 HA-specific IgA and IgG response in nasal washings and serum, respectively. Virus-specific cytotoxic T-lymphocyte responses were also induced by administration of the vaccine with extract of mycelia, resulting in protection against lethal lung infection with influenza virus A/PR8. In addition, intranasal administration of NIBRG14 vaccine derived from the influenza A/Vietnam/1194/2004 (H5N1) virus strain administered in conjunction with mycelial extracts from Phellinus linteus conferred cross-protection against heterologous influenza A/Indonesia/6/2005 virus challenge in the nasal infection model. In addition, mycelial extracts induced proinflammatory cytokines and CD40 expression in bone marrow-derived dendritic cells. These results suggest that mycelial extract-adjuvanted vaccines can confer cross-protection against variant H5N1 influenza viruses. The use of extracts of mycelia derived from edible mushrooms is proposed as a new safe and effective mucosal adjuvant for use for nasal vaccination against influenza virus infection.

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“…In particular, plantderived polysaccharides have been suggested as promising candidates for DC maturation. For example, PL polysaccharide from Phellinus linteus [31], a proteoglycan from Agaricus blazei [32], PSK from Coriolus versicolor [33], a polysaccharide from Cordyceps militaris [34], angelan from Angelica gigas Nakai [16], and acemannan from Aloe vera [35] have been found to induce phenotypic and functional maturation of murine immature DCs. Here, we demonstrate that sparan might also be a good inducer of DC maturation.…”

Section: Discussionmentioning

confidence: 99%