Water mediated reactions: TiO<sub>2</sub>and ZnO nanoparticle catalyzed multi component domino reaction in the synthesis of tetrahydroacridinediones, acridindiones, xanthenones and xanthenes

Pugazhenthi, Ilangovan; Ghouse, Shaik Mohammed; Khan, Fazlur-Rahman Nawaz; Jeong, Euh Duck; Bae, Jong Seong; Kim, Jong-Pil; Chung, Eun Hyuk; Kumar, Yadavalli Suneel; Dasaradhan, Changalaraya

doi:10.1039/c4ra13045f

Cited by 20 publications

(11 citation statements)

References 116 publications

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“…[Scheme 12, Method 2]. Further, Pugazhenthia et al [96] . discovered ZnO and TiO 2 nano‐catalyzed synthesis of acridinediones using substituted 2‐chloro‐3‐formylquinoline/arylaldehydes, dimedone, RNH 2 /NH 4 OAc under conventional heating and MW irradiation.…”

Section: Synthesis Of Acridine‐18‐dione Derivativesmentioning

confidence: 99%

“…After that, an adept, facile solvent-free, nanocrystalline TiO 2 catalyzed one pot MCR of 5,5dimethyl-1,3-cyclohexanedione and NH 4 OAc with substituted benzaldehydes to produce 1,8-dioxodecahydroacridines in moderate to excellent yields at 80°C was presented by Eidi et al [95] [Scheme 12, Method 2]. Further, Pugazhenthia et al [96] discovered ZnO and TiO 2 nano-catalyzed synthesis of acridine-diones using substituted 2-chloro-3-formylquinoline/arylaldehydes, dimedone, RNH 2 /NH 4 OAc under conventional heating and MW irradiation. Here, a range of products was synthesized in clean, safe and eco-friendly environment with high yields and recyclable catalyst [Scheme 12, Method 3,4].…”

Section: Nano-catalyzed Synthesismentioning

confidence: 99%

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Acridine‐1,8‐diones: Synthesis and Biological Applications

Sahiba¹,

Sethiya²,

Soni³

et al. 2021

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The unpretentious features of acridine‐1,8‐diones viz. presence of N‐heteroatom, electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution, bichromophoric structure and interaction ability with various proteins, make them an interesting scaffold of heterocyclic, medicinal and industrial chemistry. A tremendous development in the field of acridinediones in terms of synthetic strategies, bioactivity, industrial and other applicability has been explored in past four decades. In this perspective, an overview has been given on the state‐of‐art discoveries for the synthesis and biological applications of acridine‐1,8‐diones from 1980 to 2020. The study highlighted the history, chemistry and properties of these derivatives and provided deep insights into the synthetic protocols using various catalysts and techniques like nano‐catalyst, ionic‐liquids, microwave, ultrasound etc. under varied conditions along with biological activity against many lethal diseases. Finally, the respective prospects and limitations to these systems have been addressed. Furthermore, attempts have been done to bring many outstanding researches together and express the significance of acridine‐1,8‐diones through several aspects. We hope that the article shall deliver an impetus to explore further the synthetic values and mechanistic puzzles of acridinedione moiety and to design more promising hybrid multi‐targeted drugs and other industrial composites for the goodness of humanity

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Section: Synthesis Of Acridine‐18‐dione Derivativesmentioning

confidence: 99%

Section: Nano-catalyzed Synthesismentioning

confidence: 99%

Acridine‐1,8‐diones: Synthesis and Biological Applications

Sahiba¹,

Sethiya²,

Soni³

et al. 2021

ChemistrySelect

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“…Nano‐Zinc oxide‐catalysed synthesis of xanthenones, xanthenediones and acridinones was developed by Khan et al . The cascade reaction of cyclohexane‐1,3‐dione,

β

‐naphthol and arylaldehydes was carried out using 5 mol % ZnO in aqueous medium under microwave irradiation ( Scheme ) .…”

Section: Heterocyclic Compoundsmentioning

confidence: 99%

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Neetha¹,

Rohit²,

Saranya³

et al. 2020

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Multi-component reactions (MCRs) have gathered much attention recently due to their superior efficiency, exceptional selectivity and simplicity. Synthesis of various compounds with maximum efficiency and almost zero by-products are their major highlights. Zinc is an easily accessible, economically feasible and environmentally viable catalyst. This first review in this topic focuses on the developments in zinc-catalysed multicomponent reactions and covers literature up to 2019.

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“…We considered the bondingi nformation of zinc salicylate/stearate to explain the bondingb etween f-CNFs and the zinc precursor.O wing to the oxidation treatment, the ÀCH 3 , ÀCH 2 , ÀCH, and ÀCOOH groups are attached to the surfaceo ft he nanofibers, as discussed in the FTIR and XPS analyses. (2)], as in the following processes: [57] Most of the zinc precursorsa re converted into zinc hydroxides [Eq.…”

Section: Mechanismmentioning

confidence: 99%

Anchoring Mechanism of ZnO Nanoparticles on Graphitic Carbon Nanofiber Surfaces through a Modified Co‐Precipitation Method to Improve Interfacial Contact and Photocatalytic Performance

et al. 2015

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A facile three-step co-precipitation method is developed to synthesize graphitic carbon nanofibers (CNFs) decorated with ZnO nanoparticles (NPs). By interchanging intermediate steps of the reaction processes, two kinds of nanohybrids are fabricated with stark morphological and physicochemical differences. The morphologies differ because of the different chemical environments of the NP/nanocluster formation. The hybrid with larger and non-uniform ZnO nanocluster size is formed in liquid phase and resulted in considerable interfacial defects that deteriorate the charge-transfer properties. The hybrid with smaller and uniform ZnO NPs was formed in a dry solid phase and produced near-defect-free interfaces, leading to efficient charge transfer for superior photocatalytic performance. The results broaden the understanding of the anchoring/bonding mechanism in ZnO/CNF hybrid formation and may facilitate further development of more effective exfoliation strategies for the preparation of high-performance composites/hybrids.

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Water mediated reactions: TiO₂and ZnO nanoparticle catalyzed multi component domino reaction in the synthesis of tetrahydroacridinediones, acridindiones, xanthenones and xanthenes

Abstract: Tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones 4 from 1,3-cyclohexanedione and/or dimedone 1,2-chloro-3-formylquinoline 2 and anilines 3 in water at 90 °C were obtained by domino reaction approach.

Cited by 20 publications

References 116 publications

Acridine‐1,8‐diones: Synthesis and Biological Applications

Acridine‐1,8‐diones: Synthesis and Biological Applications

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Anchoring Mechanism of ZnO Nanoparticles on Graphitic Carbon Nanofiber Surfaces through a Modified Co‐Precipitation Method to Improve Interfacial Contact and Photocatalytic Performance

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Water mediated reactions: TiO2and ZnO nanoparticle catalyzed multi component domino reaction in the synthesis of tetrahydroacridinediones, acridindiones, xanthenones and xanthenes

Abstract: Tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones 4 from 1,3-cyclohexanedione and/or dimedone 1,2-chloro-3-formylquinoline 2 and anilines 3 in water at 90 °C were obtained by domino reaction approach.

Cited by 20 publications

References 116 publications

Acridine‐1,8‐diones: Synthesis and Biological Applications

Acridine‐1,8‐diones: Synthesis and Biological Applications

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Anchoring Mechanism of ZnO Nanoparticles on Graphitic Carbon Nanofiber Surfaces through a Modified Co‐Precipitation Method to Improve Interfacial Contact and Photocatalytic Performance

Contact Info

Product

Resources

About

Water mediated reactions: TiO₂and ZnO nanoparticle catalyzed multi component domino reaction in the synthesis of tetrahydroacridinediones, acridindiones, xanthenones and xanthenes