Water-responsive shape memory thermoplastic polyurethane scaffolds triggered at body temperature for bone defect repair

Shuai, Cijun; Wang, Zhicheng; Peng, Shuping; Shuai, Yang; Chen, Yanwen; Zeng, Da; Feng, Pei

doi:10.1039/d1qm01635k

Cited by 38 publications

(17 citation statements)

References 74 publications

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“…The cell proliferated over time, and there was no statistical difference among the groups after 4 days. However, the number of cells after 7 days showed the following order: Fe–Cu > Fe–CuO > Fe, suggesting that the incorporation of Cu favors the proliferation of MG-63 cells and vitality of cells with no cytotoxicity …”

Section: Resultsmentioning

confidence: 98%

“…However, the number of cells after 7 days showed the following order: Fe−Cu > Fe−CuO > Fe, suggesting that the incorporation of Cu favors the proliferation of MG-63 cells and vitality of cells with no cytotoxicity. 52 Previous studies have demonstrated that the toxicity of metal implants arises from the metallic ions and oxide or hydroxide layer. 53,54 The higher viabilities in Fe−Cu and Fe−CuO samples than in pure Fe indicates that the cell activity is improved by the degradation products, resulting from the Cu ions released during the degradation.…”

Section: Cytocompatibility Evaluationmentioning

confidence: 99%

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Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Zeng

Yang

et al. 2022

ACS Biomater. Sci. Eng.

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Fe has immense potential for biodegradable orthopedic applications, but it degrades slowly in the physiological environment. Inducing galvanic couple by alloying Cu to Fe using ball milling is a promising approach. However, the ductile nature of Cu leads to the cold welding of a large amount of Cu powder during ball milling, which makes it difficult to disperse uniformly in the Fe matrix. Here, a Fe−CuO implant with highly dispersed Cu particles in the matrix was developed by shift-speed ball milling and selective laser melting. Specifically, copper oxide (CuO) particles were selected as precursors and dispersed in Fe powders by ball milling since they were brittle and would not be cold-welded during ball milling. After further milling in higher energy, it was found that CuO particles reacted with Fe and generated Cu particles through a stress-activated redox reaction. Subsequently, the obtained powders were prepared into a Fe−CuO implant using selective laser melting. Microstructure examination revealed that the Cu phases in the implant were dispersed evenly in the Fe matrix, which was considered to establish a large number of galvanic couples and aggravated the galvanic corrosion tendency. Electrochemical tests indicated that the implant had improved performance in degradation behavior in terms of high corrosion current density (22.4 μA/cm 2 ), low corrosion resistance (1319 Ω cm 2 ), and good degradation stability. In addition, it presented antibacterial effects against Escherichia coli and Staphylococcus aureus by diffusion mechanisms with killing rates of 90.7 and 96.7%, respectively, as well as good cytocompatibility.

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Section: Resultsmentioning

confidence: 98%

Section: Cytocompatibility Evaluationmentioning

confidence: 99%

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Zeng

Yang

et al. 2022

ACS Biomater. Sci. Eng.

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“…The representative PLLA/Fe 3 O 4 @SiO 2 scaffold with honeycomb structure was fabricated via SLS technology. In detail, the PLLA/Fe 3 O 4 @SiO 2 powders were paved on the powder bed and selectively laser scanned according to the designed three-dimensional model, with laser power at 2.5 W, scanning speed at 100 mm/s and scanning distance at 0.24 mm [ 20 , 21 ]. The modeling platform gradually descended with each layer of powders was sintered until the scaffold was completely formed.…”

Section: Experimental Sectionsmentioning

confidence: 99%

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Shuai

Chen

et al. 2022

Biomater Res

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Background Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. Results The results show that the Fe3O4@SiO2 nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair.

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“…Meanwhile, the formed nanocomposites also demonstrate many excellent collective properties, such as enhanced light absorption, declined recombination of electron–hole pairs, and so on . Recently, two-dimensional (2D) nanomaterials as photosensitizers have attracted extensive attention of researchers because of their large surface area and distinct optical properties. , Among them, graphitic carbon nitride (g-C 3 N 4 , CN) nanosheets, as a 2D metal-free photosensitizer, have been widely reported on the aspect of photodynamic anti-infection due to their excellent biocompatibility, moderate band gap (2.7–2.8 eV), and good stability . Bismuth sulfide (Bi 2 S 3 ) nanorods, as a binary metal sulfide, are superior photothermal nanoparticles, which are widely utilized in antibacterial and antitumor studies because of their good biocompatibility, high photothermal conversion efficiency, and physicochemical stability .…”

Section: Introductionmentioning

confidence: 99%

Photothermal and Photodynamic Effects of g-C₃N₄ Nanosheet/Bi₂S₃ Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair

Qian

Wen

Shuai

et al. 2022

ACS Appl. Nano Mater.

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Photodynamic antimicrobial therapy via producing ROS based on light-responsive nanoparticles has attracted worldwide attention because of the high selectivity and low side effects. However, biofilms and bacterial membranes provide a natural barrier to prevent the penetration of ROS, which impairs the photodynamic antibacterial efficiency of nanoparticles. Photothermal therapy is an effective strategy against biofilms and bacterial membranes because high temperature can destroy the biofilm structure and enhance the membrane permeability. Herein, Bi2S3 nanorods were anchored on the surface of zinc-doped g-C3N4 (ZnCN) nanosheets to construct a ZnCN-Bi2S3 nanocomposite; then, it was incorporated into poly-l-lactic acid and prepared into scaffolds by the selective laser sintering technology. Bi2S3 nanorods not only endowed the scaffold with an excellent photothermal property but also strengthened the photodynamic effect of ZnCN nanosheets after forming the nanocomposite. The results showed that this nanocomposite had a lower recombination rate of photogenerated electron–hole pairs and produced higher photocurrent compared to those of the g-C3N4 nanosheets and Bi2S3 nanorods. The scaffold destroyed the biofilm and elevated the bacterial membrane permeability significantly and finally achieved 98.5% antibacterial rate for Staphylococcus aureus and 96.3% antibacterial rate for Pseudomonas aeruginosa. Encouragingly, the scaffold could also promote chondrogenic differentiation because of the continuous release of Zn ions. The scaffold containing ZnCN-Bi2S3 nanocomposites possessed excellent antimicrobial and cartilage regeneration functions, which displayed great potential in treating tracheal injuries.

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Water-responsive shape memory thermoplastic polyurethane scaffolds triggered at body temperature for bone defect repair

Abstract: Combining selective laser sintering (SLS) and water-responsive shape memory polymer triggered at body temperature is highly promising for the accomplishment of bone defect repair with the approach of minimally invasive...

Cited by 38 publications

References 74 publications

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Photothermal and Photodynamic Effects of g-C₃N₄ Nanosheet/Bi₂S₃ Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair

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Water-responsive shape memory thermoplastic polyurethane scaffolds triggered at body temperature for bone defect repair

Abstract: Combining selective laser sintering (SLS) and water-responsive shape memory polymer triggered at body temperature is highly promising for the accomplishment of bone defect repair with the approach of minimally invasive...

Cited by 38 publications

References 74 publications

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Photothermal and Photodynamic Effects of g-C3N4 Nanosheet/Bi2S3 Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair

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Product

Resources

About

Photothermal and Photodynamic Effects of g-C₃N₄ Nanosheet/Bi₂S₃ Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair