Water-soluble conjugated polymers for bioelectronic systems

Abstract

Bioelectronics is an interdisciplinary field of research that aims to establish a synergy between electronics and biology. Contributing to a deeper understanding of bioelectronic processes and the built bioelectronics systems,...

Increased Nitrogenase Activity in Solar‐Driven Biohybrids Containing Non‐photosynthetic Bacteria and Conducting Polymers

“…For A. Chroococcum treated with 2 μM PFP, the content of NH 4 + -N is increased from 0.97 to 1.40 μg/10 9 cell (a 44 % increment) and that of the intracellular L-amino acids is increased from 3.06 to 4.51 nmol/10 9 cell (a 47 % increment). The abundance ratio of 15 N to 14 N (δ 15 N/ 14 N) of A. Chroococcum increased from 39 to 77 (a 97 % increment) in the presence of PFP, consistent with enhanced nitrogen fixing ability under illumination (Figure 5f and S13). Taken all together, PFP can promote the nitrogen fixation of A. Chroococcum under illumination, which is reflected in the increased ethylene and hydrogen evolution, the NH 4 + -N, L-amino acids contents, and the abundance ratio of 15 N to 14 N. Differential pulse voltammetry reveals oxidation peaks in 0.45 V and 0.55 V in the culture medium after the nitrogen fixation process, see Figure 5g.…”

“…The abundance ratio of 15 N to 14 N (δ 15 N/ 14 N) of A. Chroococcum increased from 39 to 77 (a 97 % increment) in the presence of PFP, consistent with enhanced nitrogen fixing ability under illumination (Figure 5f and S13). Taken all together, PFP can promote the nitrogen fixation of A. Chroococcum under illumination, which is reflected in the increased ethylene and hydrogen evolution, the NH 4 + -N, L-amino acids contents, and the abundance ratio of 15 N to 14 N. Differential pulse voltammetry reveals oxidation peaks in 0.45 V and 0.55 V in the culture medium after the nitrogen fixation process, see Figure 5g. A freshly prepared bacterial culture medium did not exhibit such peaks.…”

“…Flavoproteins (Fp) serve as redox mediators to shuttle light generated electrons into bacterial cells. [15] Accordingly, it seemed reasonable that Fp could serve as pathways for PFP-generated to A. Chroococcum. Cyclic voltammetry (CV) measurements of A. Chroococcum showed that a redox peak at À 0.31 V (vs Ag/AgCl) could be reasonably attributed to Fp (Figure S1).…”

Protein-Assisted Molybdenum Disulfide as Biomimetic Nanozyme for Antibacterial Application

“…Single-strand DNA physically adsorbed on the surface of molybdenum disulfide, improved their affinity to the substrate and enhanced catalytic activity . Organic compounds including small molecules and polymers process tunable molecular structures, which can induce chemical bonding or physical interactions. − Among them, biomolecules are biocompatible. Their charged groups or active groups can form complexes with molybdenum disulfide to modify their surface properties. − Derived from the objective biological application, the synthesis and modification of molybdenum disulfide can be assisted by biomolecules, paving their way as biomimetic nanozymes.…”

A biophotonic device based on a conjugated polymer and a macrophage-laden hydrogel for triggering immunotherapy

“…In this regard, water-soluble conjugated polymers (WSCPs) with p-conjugated backbones and positively charged side chains can make contributions due to their excellent biocompatibility and photosensitivity. [26][27][28][29][30] Moreover, benefitting from the facile modifiability of organic compounds, WSCPs have demonstrated a wide optical adjustment range which is favorable for cooperation with multiple luminescence modalities such as chemiluminescence, bioluminescence and electroluminescence to fabricate bio-electronic devices for biomedical applications. 31 But the profile electroluminescent technology of OLEDs has not cooperated with WSCPs, even though OLEDs can be used as the irradiation source for photosensitizing oxygen and generating ROS.…”