Water-Soluble Peptide-Coated Nanoparticles: Control of the Helix Structure and Enhanced Differential Binding to Immune Cells

Abstract

The stabilizing action of C(α)-tetrasubstituted α-amino acids inserted into a sequence of short peptides allowed for the first time the preparation of water-soluble nanoparticles of different materials coated with a helix-structured undecapeptide. This peptide coating strongly favors nanoparticle uptake by human immune system cells.

Identification and optimization of short helical peptides with novel reactive functionality as catalysts for acyl transfer by reactive tagging

“…7). [32][33][34] The same feature was observed for all peptides containing 3-pyridylalanine (Table 1, Fig. S5 †), independent of catalytic activity.…”

“…6b and Table 1, entries 1 and 8). [32][33][34] The 15-residue peptide-hit, His-3Py-Cit 4T, shows a smaller increase in α-helical content with respect to His-3Py-Cit 2T, with R increasing from a two-turn value of 0.66 to 0.72 ( Fig. 7 and Table 1, entries 2 and 9).…”

Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides

“…24,30,35 In this work, we demonstrate a simple and cost-effective self-assembly approach to prepare peptide functionalized MSNs, as a promising alternative for covalent attachment methods. 13 Our method is based on the spontaneous attachment of peptide amphiphiles (PAs) to the octyl modied MSN surfaces in aqueous media through hydrophobic interactions between octyl groups of MSNs and alkyl chains of PAs (Scheme 1a).…”

Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays

“…6–11 CPEs are described by a π-conjugated backbone with ionic pendant groups, which make them water-soluble and/or bio-compatible. A range of cationic and anionic CPEs have been synthesized for specific applications including bioimaging, bioelectronics, fluorescent probes and signaling mediation.…”