Water soluble transition metal [Ni(ii), Cu(ii) and Zn(ii)] complexes of N-phthaloylglycinate bis(1,2-diaminocyclohexane). DNA binding, pBR322 cleavage and cytotoxicity

Abstract

A series of water-soluble ionic complexes (1–3) were synthesized as potent anticancer agents.

Repurposing the antihistamine drug bilastine as an anti-cancer metallic drug entity: synthesis and single-crystal X-ray structure analysis of metal-based bilastine and phen [Co(ii), Cu(ii) and Zn(ii)] tailored anticancer chemotherapeutic agents against resistant cancer cells

“…However, after the addition of complexes to the EB + DNA system, the complexes compete with EB, and EB is partially knocked out of the helix, which caused a decrease in the fluorescence emission of the EB + DNA system. 35 The decrease in emission intensity at 585 and 595 nm in the EB + DNA systems on addition of complexes 1–3 implicated the breakdown of the EB + DNA complex due to the insertion of a drug molecule, 36 as illustrated in Fig. 5.…”

Hydrazylpyridine salicylaldehyde–copper(ii)–1,10-phenanthroline complexes as potential anticancer agents: synthesis, characterization and anticancer evaluation

“…The cytotoxic activity of Cugdupt1–Cugdupt9 was evaluated by the CCK-8 assays to assess IC 50 values (μM) 36,37 on A549 and A549cis cancer cells as well as HL-7702 normal cells. Cugdupt1–Cugdupt9 exhibited significantly greater potency for A549cis cells than A549 and HL-7702 cells with different toxicity from cisplatin (Table 2).…”

Ru(II)(ƞ6-p-cymene) Conjugates Loaded onto Graphene Oxide: An Effective pH-Responsive Anticancer Drug Delivery System

“…The change in electrophoretic mobility of pBR322 plasmid DNA on agarose gel provided further evidence for DNA-drug interactions [ 36 , 37 , 38 ]. The migration of pBR322 plasmid DNA from its supercoiled form (Form I) to its nicked (Form II) or linear form (Form III) after its interaction with drug candidates provides evidence for DNA-drug interactions [ 39 ].…”