Water-Soluble Vitamins and Nonnutrients

Kohlmeier, Martin

doi:10.1016/b978-0-12-387784-0.00010-9

Cited by 9 publications

(4 citation statements)

References 273 publications

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“…TPP is the active form of thiamine that serves as a cofactor for several enzymes in energy metabolism. [ 14 ] There are three central enzymes of metabolism that require TPP. These enzymes are pyruvate dehydrogenase (PDH), alpha-ketoglutarate dehydrogenase and transketolase.…”

Section: Methodsmentioning

confidence: 99%

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Panda,

Heidari,

Borumand

et al. 2024

Journal of Family Medicine and Primary Care

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Diabetic ketoacidosis (DKA) is a life-threatening condition affecting individuals with diabetes characterised by hyperglycaemia, metabolic acidosis and ketonemia. The incidence and financial burden of DKA is still high. Thiamine deficiency is well documented in patients with DKA and could be associated with cardiac dysfunction in those patients. Thiamine deficiency leads to cardiac dysfunction, neuronal death and worsens the prognosis of DKA. There is an existing metabolic relationship between thiamine deficiency in diabetes, obesity and bariatric surgery. Careful monitoring of thiamine, along with other vitamins, is essential for diabetic patients, obese individuals and postbariatric surgery. Further research and clinical studies are urgently needed to assess the following: (1) Whether diabetes, obesity and bariatric surgery make individuals more prone to have DKA related to thiamine deficiency and (2) Whether supplementation of thiamine can protect diabetic patients, obese subjects and individuals undergoing bariatric surgery from DKA. This review summarises the biochemistry of thiamine and the existing metabolic relationships between thiamine deficiency in DKA, diabetes, obesity and bariatric surgery. Primary and family physicians have an important role in ensuring adequate replacement of thiamine in individuals with diabetes, obesity and bariatric surgery.

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Section: Methodsmentioning

confidence: 99%

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Panda,

Heidari,

Borumand

et al. 2024

Journal of Family Medicine and Primary Care

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“…Then, when it reaches the intestinal cells, free VB 1 is phosphorylated to thiamin pyrophosphate by thiamin pyrophosphokinase. [39]…”

Section: Modelsmentioning

confidence: 99%

Liposoluble vitamin B₁ microcapsules: Preparation, characterization, stabilization, and bioaccessibility

Tian

Peng

et al. 2023

Euro J Lipid Sci & Tech

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Thiamine (VB1) is an essential water‐soluble vitamin that is necessary in our daily diet. However, its instability when exposed to external factors poses a limitation on its application in the food industry. To address this issue and increase its application in fat‐rich food systems, this study developed liposoluble VB1 microcapsules via freeze‐drying, utilizing β‐cyclodextrin as a wall material and polyglycerol fatty acid ester as an emulsifying agent. The VB1 microcapsules were characterized in terms of their particle size distribution, morphology, solubility, and stability in soybean oil, as well as their in vitro bioaccessibility. The results showed that the average particle size of VB1 microcapsules was 83.73 μm with a nonuniform, somewhat wrinkled spherical structure. The solubility of the VB1 microcapsules in soybean oil was increased to 142.86 mg kg–1. The retention rates of VB1 in soybean oil was found to be above 95% after 48 h of UV irradiation and 96.44% after heating for 7 days at 60°C. The presence of VB1 microcapsules did not significant impact on the oxidation stability of soybean oil. The bioaccessibility of VB1 in soybean oil was 82.81%. This work provides a useful and novel direction for the application of VB1 in high‐fat diets.

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“…Biotin is a water-soluble B vitamin that is ubiquitous in all living organisms. It is a crucial cofactor for carboxylase enzymes that facilitate the transfer of CO 2 groups during biosynthesis [ 1 ]. Biotin binds to the chicken egg white protein avidin and the homologous protein streptavidin with extremely high affinity (dissociation constant K D = 10 −15 M) and specificity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

AviTrap: A novel solution to achieve complete biotinylation

Lu,

Bevers,

Tyagi

et al. 2024

PLoS ONE

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Site specific biotinylation of AviTagged recombinant proteins using BirA enzyme is a widely used protein labeling technology. However, due to the incomplete biotinylation reactions and the lack of a purification method specific for the biotinylated proteins, it is challenging to purify the biotinylated sample when mixed with the non-biotinylated byproduct. Here, we have developed a monoclonal antibody that specifically recognizes the non-biotinylated AviTag but not the biotinylated sequence. After a ten-minute incubation with the resin that is conjugated with the antibody, the non-biotinylated AviTagged protein is trapped on the resin while the fully biotinylated material freely passes through. Therefore, our AviTrap (anti-AviTag antibody conjugated resin) provides an efficient solution for enriching biotinylated AviTagged proteins via a simple one-step purification.

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Water-Soluble Vitamins and Nonnutrients

Cited by 9 publications

References 273 publications

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Liposoluble vitamin B₁ microcapsules: Preparation, characterization, stabilization, and bioaccessibility

AviTrap: A novel solution to achieve complete biotinylation

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Water-Soluble Vitamins and Nonnutrients

Cited by 9 publications

References 273 publications

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Liposoluble vitamin B1 microcapsules: Preparation, characterization, stabilization, and bioaccessibility

AviTrap: A novel solution to achieve complete biotinylation

Contact Info

Product

Resources

About

Liposoluble vitamin B₁ microcapsules: Preparation, characterization, stabilization, and bioaccessibility