Water-Sorption Properties of Tablet Disintegrants

Khan, K. A.; Rhodes, C. T.

doi:10.1002/jps.2600640321

Cited by 56 publications

(24 citation statements)

References 4 publications

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“…This finding demonstrated that the resin (Amberlite IRP-69) could act as a disintegrant, as previously found with other resins, e.g. Amberlite IRP-88 and Indion 414 (4,10,27). The disintegration Fig.…”

Section: Effect On Drug Release In DIsupporting

confidence: 86%

“…The resins have been primarily used as drug carriers for the development of controlled release systems, and as taste maskers in preparations of suspensions and chewing gums of bitter drugs. Furthermore, resins with a high propensity for swelling can act like a disintegrant, usable in tablet formulations (10,11). Recently, it was found that the direct compression of some resins with other matrix components can modify drug release from matrices without need for prior formation of resinate (4).…”

Section: Introductionmentioning

confidence: 99%

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Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

et al. 2008

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Abstract. This work was aimed at evaluating the effect of a pharmaceutical cationic exchange resin (Amberlite IRP-69) on the properties of controlled release matrices using Methocel K4M (HPMC) or Ethocel 7cP (EC) as matrix formers. Diphenhydramine hydrochloride (DPH), which was cationic and water soluble, was chosen as a model drug. HPMC-and EC-based matrices with varying amounts (0-40%w/w) of resin incorporation were prepared by a direct compression. Matrix properties including diameter, thickness, hardness, friability, surface morphology and drug release were evaluated. The obtained matrices were comparable in diameter and thickness regardless of the amount of resin incorporation. Increasing the incorporated resin decreased the hardness of HPMC-and EC-based matrices, correlating with the degree of rupturing on the matrix surfaces. The friability of HPMC-based matrices increased with increasing the incorporated resin, corresponding to their decreased hardness. In contrast, the EC-based matrices showed no significant change in friability in spite of decreasing hardness. The incorporated resin differently influenced DPH release from HPMC-and EC-based matrices in deionized water. The resin further retarded DPH release from HPMC-based matrices due to the gelling property of HPMC and the ion exchange property of the resin. In contrast, the release from EC-based matrices initially increased because of the disintegrating property of the resin, but thereafter declined due to the complex formation between released drug and dispersed resin via the ion exchange process. The release in ionic solutions was also described. In conclusion, the incorporated resin could alter the release and physical properties of matrices.

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Section: Effect On Drug Release In DIsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

et al. 2008

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“…To this regard, a new group of disintegrants, referred to as "superdisintegrants", has been developed. Several materials proven to be superdisintegrants are sodium starch glycolate (modified starch), croscarmellose sodium (crosslinked cellulose), crospovidone (crosslinked polyvinylpyrrolidone) and polacrilin potassium (cationic exchange resin) [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The ionizable groups make the resin capable of hydration and swelling in an aqueous fluid [7]. Therefore, ion exchange resins have been exploited as effective disintegrants in tablet formulation [5,6], in addition to other diverse applications [8,9]. Nonetheless, this disintegrant application has been limited to only a cationic exchange resin derived from crosslinked methacrylic acid and divinylbenzene copolymer in a potassium salt form, i.e.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of some anionic exchange resins as potential tablet disintegrants

Akkaramongkolporn

Pattarakan²,

Opanasopit³

et al. 2014

Trop. J. Pharm Res

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“…They also have discussed the effect of moisture on their physical characteristics such as compressibility, compactability, and glass transition and these methods would be useful in studying the effect of moisture on disintegrants as well. Moisture effects on disintegrants such as starch, sodium carboxymethyl cellulose and sodium starch glycolate (15,16), croscarmellose sodium, and crospovidone (16) have been studied extensively. Faroongsarng et al (17) studied dynamic vapor sorption and thermal behavior of four disintegrants: microcrystalline cellulose, croscarmellose sodium, corn starch, and sodium starch glycolate.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF

Bele

Derle

2011

AAPS PharmSciTech

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Abstract. Polacrilin Potassium NF is a commonly used weak cation exchange resin disintegrant in pharmaceutical tablets. The objective of this research was to evaluate the effects of sorbed moisture on physical characteristics and disintegrant performance of four brands of Polacrilin Potassium NF. The disintegrants were stored in five different relative humidity chambers and their dynamic vapor adsorption-desorption analysis, effect of moisture on their compressibility, compactability, particle size, morphology, water uptake rate, and disintegration ability were studied. Moisture seemed to plasticize the disintegrants, reducing their yield pressures. However, certain optimum amount of moisture was found to be useful in increasing the compactablity of the tablets containing disintegrants. The tablets, however, lost their tensile strengths beyond this optimum moisture content. Moisture caused two brands of the disintegrants to swell; however, two other brands aggregated upon exposure to moisture. Swelling without aggregation increased the water uptake, and in turn the disintegrant performance. However, aggregation probably reduced the porosities of the disintegrants, reducing their water uptake rate and disintegrant performance. Different brands of Polacrilin Potassium NF differed in the abilities to withstand the effects of moisture on their functionality. Effect of moisture on disintegrant performance of Polacrilin Potassium NF needs to be considered before its use in tablets made by wet granulation.

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Water-Sorption Properties of Tablet Disintegrants

Cited by 56 publications

References 4 publications

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

Evaluation of some anionic exchange resins as potential tablet disintegrants

Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF

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