Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing

Zhu, Jing; Qiu, Weiwang; Yao, Chengjian; Wang, Chun; Wu, Dequn; Pradeep, Shravan; Yu, Jianyong; Dai, Zijian

doi:10.1016/j.jcis.2021.06.084

Cited by 30 publications

(24 citation statements)

References 46 publications

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“…The membrane was loaded with β-CD COF enrofloxacin and flunixin meglumine, which both had antibacterial and anti-inflammatory properties and made wound healing easier [ 150 ]. In addition, the introduction of an MOF loaded with the antibacterial drug levofloxacin (LV) onto polyvinyl alcohol (PVA) membranes can be used to improve the water stability and antibacterial performance of nanofiber membranes (NFM) [ 151 ].…”

Section: Application Of Mofs In Wound Healingmentioning

confidence: 99%

“…Therefore, it is urgent to develop antibacterial materials with inherent antibacterial properties and low toxicity without drug resistance to solve the problem of wound site infection. Over the past decade, metallic antibacterial agents such as zinc-, silver-, and copper-based oxides or ions have been used to kill or inhibit bacterial growth on wounds [ 151 , 176 , 190 ] ( Table 3 ).…”

Section: Application Of Mofs In Wound Healingmentioning

confidence: 99%

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Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

et al. 2022

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Diabetes-related chronic wounds are often accompanied by a poor wound-healing environment such as high glucose, recurrent infections, and inflammation, and standard wound treatments are fairly limited in their ability to heal these wounds. Metal–organic frameworks (MOFs) have been developed to improve therapeutic outcomes due to their ease of engineering, surface functionalization, and therapeutic properties. In this review, we summarize the different synthesis methods of MOFs and conduct a comprehensive review of the latest research progress of MOFs in the treatment of diabetes and its wounds. State-of-the-art in vivo oral hypoglycemic strategies and the in vitro diagnosis of diabetes are enumerated and different antimicrobial strategies (including physical contact, oxidative stress, photothermal, and related ions or ligands) and provascular strategies for the treatment of diabetic wounds are compared. It focuses on the connections and differences between different applications of MOFs as well as possible directions for improvement. Finally, the potential toxicity of MOFs is also an issue that we cannot ignore.

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Section: Application Of Mofs In Wound Healingmentioning

confidence: 99%

Section: Application Of Mofs In Wound Healingmentioning

confidence: 99%

Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

et al. 2022

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“… 36 The synergy of materials for protecting against bacterial infections was observed in poly(vinyl alcohol)/UiO-66-NH 2 composites which showed higher performance than commercially available gauzes used for the wound healing process. 37 Further, the synergistic antibacterial activity between polymers and MOFs has been observed in polyacrylonitrile/gelatin nanofibers coated with ZIF-8 loaded with gentamicin to accelerate the wound repair. 38 …”

Section: Introductionmentioning

confidence: 97%

Tailoring biocompatibility of composite scaffolds of collagen/guar gum with metal–organic frameworks

et al. 2022

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“…For decades, the number of deaths caused by bacterial infections has been increasing, and bacterial infections have become a significant threat to human health. − In recent years, the use of antibiotics has been increasing worldwide; more and more antibiotics are becoming resistant and threatening public health in a variety of ways, leading to severe clinical outcomes and high mortality rates. − There is an urgent need to develop new antimicrobial nanoparticles that can overcome drug resistance without any other side effects for patients. , …”

Section: Introductionmentioning

confidence: 99%

Au–Cu Bimetallic Nanostructures for Photothermal Antibacterial and Wound Healing Promotion

Song

Liu

Zhang

et al. 2022

ACS Appl. Nano Mater.

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The spread of drug-resistant bacterial infections can lead to serious infectious diseases and pose a significant threat to public health security. Metallic-nano-antibacterial materials are gradually becoming a hot spot for antimicrobial biomaterials research with the advantages of long service life and fast effective bactericidal speed. Considering the construction of a safe and efficient photothermal therapy (PTT) antibacterial platform as a promising strategy for the treatment of bacterial infections, a near-infrared (NIR) bimetallic antibacterial nanoparticle, adenosine 5′-triphosphate (ATP)@Au-Cu nanoparticle (NP), with excellent photothermal conversion efficiency (59.3%) was prepared in this paper; ATP@Au-CuNPs with their multiarm shaped structure and NIR photothermal effect could significantly inhibit the growth of bacteria at the low concentrations. In addition, the cytotoxicity and hemolysis rate of the ATP-coated nanoparticles were reduced considerably, and they also exhibited antibacterial and wound healing-promoting effects in mice wound infection models. On this basis, this paper focuses on the preparation and properties of ATP@Au-CuNPs and explores their biological application in antibacterial therapy.

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Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing

Cited by 30 publications

References 46 publications

Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

Tailoring biocompatibility of composite scaffolds of collagen/guar gum with metal–organic frameworks

Au–Cu Bimetallic Nanostructures for Photothermal Antibacterial and Wound Healing Promotion

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