Water ultrasound-assisted oxidation of 2-oxo-1,2,3,4-tetrahydropyrimidines and benzylic acid salts

A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities

“…There is an burning need to design and synthesis of novel prospective dual-active compounds, especially anticancer-antiviral [ [32] , [33] , [34] ]. Our interest is the design, synthesis, and pharmacological evaluation of the heterocyclic compounds, especially those derived from the Biginelli reaction [ [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] ]. Selected molecules have proven to be excellent ligands for the synthesis of copper and palladium complexes with significant anticancer and antimicrobial activity [ [44] , [45] , [46] , [47] ].…”

Chitosan nanobeads loaded with Biginelli hybrids as cell-selective toxicity systems with a homogeneous distribution of the cell cycle in cancer treatment

“…However, although the Biginelli reaction yields a huge number of compounds with a broad range of activities, none of them were captured in a carrier. Given the above considerations, our combined interest in sustainable, green and Biginelli chemistry, [21][22][23][24][25][26][27] has inspired us to develop specic sustainable formulations with fast delivery and improved cytotoxic selectivity of the selected Bignelli hybrids in targeting cancer cell lines.…”

Water-Tuned Tautomer-Selective Tandem Synthesis of the 5,6-Dihydropyrimidin-4(3H)-ones, Driven under the Umbrella of Sustainable Chemistry

“…Both protocols performed with solvents indicate that high tautomer purity (≥99%), in Atwal’s modification of the Biginelli reaction, was a very problematic synthetic challenge and, so far, it has not been achieved. Bearing in mind the aforementioned facts, our combined experiences and interest in green synthesis , and multicomponent synthesis − prompted us to explore and develop novel and, at the same time, green synthetic strategies for the synthesis of 6-aryl-5,6-dihydropyrimidin-4­(3 H )-ones in a highly tautomer-selective manner.…”