Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

Yan, Wei; Zhou, Youxiang; Yang, Jie; Li, Shuqian; Ding-jin, HU; Wang, Jianghua; Chen, Jun; Li, Guangyu

doi:10.1016/j.chemosphere.2012.01.041

Cited by 87 publications

(49 citation statements)

References 54 publications

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“…Given the known need for balanced thyroid hormone levels and concerns raised about thyroid-targeting endocrine disruptors found in global water supplies (Brechner et al, 2000;Weyer and Riley, 2001;Jugan et al, 2009;Shi et al, 2009;Yan et al, 2012), the results of these experiments will be relevant to species affected by environmental thyroid disruption as well as clinical studies examining the effects of developmental MMI exposure.…”

Section: Introductionmentioning

confidence: 97%

Effects of Low‐Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish

Reider

Connaughton

2014

Birth Defects Research Pt B

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Thyroid hormones are required for vertebrate development, and disruption of the thyroid system in developing embryos can result in a large range of morphologic and physiologic changes, including in the eye and retina. In this study, our anatomic analyses following low-dose, chronic thyroid inhibition reveal that both methimazole (MMI) exposure and rearing temperature affect eye development in a time- and temperature-dependent fashion. Maximal sensitivity to MMI for external eye development occurred at 65 hr postfertilization (hpf) for zebrafish reared at 28°C, and at 69 hpf for those reared at 31°C. Changes in eye diameter corresponded to changes in thickness of two inner retinal layers: the ganglion cell layer and the inner plexiform layer, with irreversible MMI-induced decreases in layer thickness observed in larvae treated with MMI until 66 hpf at 28°C. We infer that maximal sensitivity to MMI between 65 and 66 hpf at 28°C indicates a critical period of thyroid-dependent eye and retinal development. Furthermore, our results support previous work that shows spontaneous escape from MMI-induced effects potentially due to embryonic compensatory actions, as our data show that embryos treated beyond the critical period generally resemble controls.

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Section: Introductionmentioning

confidence: 97%

Effects of Low‐Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish

Reider

Connaughton

2014

Birth Defects Research Pt B

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“…Besides modulating the HPG axis, it has also been previously demonstrated that MCs alter the metabolism of cortisol and thyroid hormone, through activating the hypothalamic-pituitary-adrenal/interrenal (for fish) (HPA/HPI) and hypothalamic-pituitary-thyroid (HPT) axis [130][131][132][133][134][135][136]. As mentioned above, the endocrine system is very complex and affected by many factors, and previous studies have shown that liver damage may not only induce sex hormone changes [127], but also reduce hepatic thyroxine deiodination in animals [137], which in turn causes a decline in peripheral triiodothyronine production [130].…”

Section: Sex Hormones Hpg Axis Liver and Endocrine-disrupting Effectsmentioning

confidence: 99%

A review of reproductive toxicity of microcystins

Chen

Zhang

et al. 2016

Journal of Hazardous Materials

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309

126

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“…So far, numerous incidents of MCs intoxication have been reported in animals and humans, among which the most serious one is the deaths of over 50 hemodialysis patients in Caruaru, Brazil in 1996 (Pouria et al, 1998;Metcalf et al, 2001;Lürling and Faassen, 2013). MCs have more than 100 different structural analogs and the most common and toxic one is microcystin-leucine-arginine (MC-LR) (Zhang et al, 2009;Yan et al, 2012). It is well known that MC-LR has potent hepatotoxicity and tumor-promoting activity (Nishiwaki-Matsushima et al, 1992;, which targets the liver and can induce various liver diseases including hepatitis and carcinoma (Chen et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effects of microcystin-LR on gut microflora in different gut regions of mice

et al. 2015

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-To reveal the toxicological effects of the hepatotoxic microcystin-leucine arginine (MC-LR) on gut microbial community composition in different gut regions, we conducted a subchronic exposure of BALB/c mice to MC-LR via intragastric administration. Denaturing gradient gel electrophoresis (DGGE) was employed to profile the shifts of microbes after MC-LR treatment in the jejuno-ileum, caecum and colon. DGGE profiles analysis showed that MC-LR increased the microbial species richness (number of microbial bands) in the caecum and colon as well as microbial diversity (ShannonWiener index) in the caecum. The cluster analysis of DGGE profiles indicated that the microbial structures in the caecum and colon shifted significantly after MC-LR treatment, while that in the jejuno-ileum did not. All the relatively decreased gut microbes belonged to Clostridia in the Firmicutes phylum, and most of them were Lachnospiraceae. The increased ones derived from a variety of microbes including species from Porphyromonadaceae and Prevotellaceae in the Bacteroidetes phylum, as well as Lachnospiraceae and Ruminococcaceae in the Firmicutes phylum, and among which, the increase of Barnesiella in Porphyromonadaceae was most remarkable. In conclusion, subchronic exposure to MC-LR could disturb the balance of gut microbes in mice, and its toxicological effects varied between the jejuno-ileum and the other two gut regions.

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Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

Cited by 87 publications

References 54 publications

Effects of Low‐Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish

Effects of Low‐Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish

A review of reproductive toxicity of microcystins

Effects of microcystin-LR on gut microflora in different gut regions of mice

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