Abstract. In the present work, an advanced tsunami generation, propagation and coastal inundation 2-DH model (i.e. 2-D Horizontal model) based on the higher-order Boussinesq equations -developed by the authors -is applied to simulate representative earthquake-induced tsunami scenarios in the Eastern Mediterranean. Two areas of interest were selected after evaluating tsunamigenic zones and possible sources in the region: one at the southwest of the island of Crete in Greece and one at the east of the island of Sicily in Italy. Model results are presented in the form of extreme water elevation maps, sequences of snapshots of water elevation during the propagation of the tsunamis, and inundation maps of the studied low-lying coastal areas. This work marks one of the first successful applications of a fully nonlinear model for the 2-DH simulation of tsunami-induced coastal inundation; acquired results are indicative of the model's capabilities, as well of how areas in the Eastern Mediterranean would be affected by eventual larger events.