Wave front migration of endothelial cells in a bone-implant interface

Khalil, Georges; Lorthois, Sylvie; Marcoux, Manuel; Mansat, Pierre; Swider, Pascal

doi:10.1016/j.jbiomech.2011.05.008

Cited by 9 publications

(10 citation statements)

References 43 publications

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“…It has been shown that in a clinical setting, following implantation, several cell types migrate towards the implant surface including endothelial cells, osteoblasts and stem cells (Khalil et al, 2011). This is a very important step for osteoinduction and over time, this accumulation at the implant surface will enhance implant stability and its success (Javed et al, 2013, Truhlar et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Low dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface in vitro

et al. 2017

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Since the 1980s, titanium (Ti) implants have been routinely used to replace missing teeth. This success is mainly due to the good biocompatibility of Ti and the phenomenon of osseointegration, with very early events at implant placement being important in determining good osseointegration. However, enhancing implant performance with coatings such as hydroxyapatite (HA) and calcium phosphate has proved largely unsuccessful. Human mesenchymal stem cells (hMSCs) are the first osteogenic cells to colonise implant surfaces and offer a target for enhancing osseointegration. We previously reported that small doses of bisphosphonate (BP) may play an integral role in enhancing hMSC proliferation and osteogenic differentiation. The aim of this study is to investigate whether small doses of bisphosphonates enhance proliferation and osteogenic differentiation of hMSCs on Ti surfaces, to enhance bone osseointegration and to accelerate wound healing around the implant surface. Our data suggests that treating cells with small doses of BP (100 nM & 10 nM) induces significant hMSC stimulation of osteogenic markers including calcium, collagen type I and ALP compared to control group on titanium surfaces (P < 0.05). In addition, cell proliferation and migration were significantly enhanced on titanium surfaces (P < 0.05).

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Section: Discussionmentioning

confidence: 99%

Low dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface in vitro

et al. 2017

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“…In contrast, alleviating the oxygen deprivation during the prevascular phase of large implants demands release periods of multiple days to weeks. [ 20 , 21 ] Interestingly, week-long oxygen generation could potentially be achieved by encapsulating a solid peroxide such as calcium peroxide (CaO 2 ; CPO) in hydrophobic bulk material. [ 22 ] Specifically, a material’s hydrophobic nature could be used to limit the exposure of encapsulated solid peroxides to water molecules, which effectively grants control over the hydrolysis rate of solid peroxides and hence oxygen release.…”

Section: Introductionmentioning

confidence: 99%

Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants

Farzin

Hassan

Teixeira

et al. 2021

Adv Funct Materials

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Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full-thickness vascularization that is required for long-term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre-vascular phase, implanted engineered tissues are forced to metabolically rely on the diffusion of nutrients from adjacent host-tissue, which for larger living implants results in anoxia, cell death, and ultimately implant failure. Here it is reported that this challenge can be addressed by engineering self-oxygenating tissues, which is achieved via the incorporation of hydrophobic oxygen-generating micromaterials into engineered tissues. Self-oxygenation of tissues transforms anoxic stresses into hypoxic stimulation in a homogenous and tissue sizeindependent manner. The in situ elevation of oxygen tension enables the sustained production of high quantities of angiogenic factors by implanted cells, which are offered a metabolically protected pro-angiogenic microenvironment. Numerical simulations predict that self-oxygenation of living tissues will effectively orchestrate rapid full-thickness vascularization of implanted tissues, which is empirically confirmed via in vivo experimentation. Self-oxygenation of tissues thus represents a novel, effective, and widely applicable strategy to enable the vascularization living implants, which is expected to advance organ transplantation and regenerative medicine applications.

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“…Computationally unwieldy models can occur even with simplified loading, simplified boundary conditions, simplified geometry and heterogeneity of tissue distribution and assumptions on the nature of the interface connections. While numerical models for predicting bone and tissue adaptation traditionally focus on mechanical and structural analysis, it is important to consider the contribution of other factors such as biologic and biochemical [36,37]. Incorporating complex mixed mechanics (solid þ fluid, poromechanics, reactive media) carries the challenge of providing rigorous validation on clinically relevant measures [38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Experimental and Numerical Models of Complex Clinical Scenarios; Strategies to Improve Relevance and Reproducibility of Joint Replacement Research

Bechtold

Swider²,

Goreham-Voss

et al. 2016

Journal of Biomechanical Engineering

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This research review aims to focus attention on the effect of specific surgical and host factors on implant fixation, and the importance of accounting for them in experimental and numerical models. These factors affect (a) eventual clinical applicability and (b) reproducibility of findings across research groups. Proper function and longevity for orthopedic joint replacement implants relies on secure fixation to the surrounding bone. Technology and surgical technique has improved over the last 50 years, and robust ingrowth and decades of implant survival is now routinely achieved for healthy patients and first-time (primary) implantation. Second-time (revision) implantation presents with bone loss with interfacial bone gaps in areas vital for secure mechanical fixation. Patients with medical comorbidities such as infection, smoking, congestive heart failure, kidney disease, and diabetes have a diminished healing response, poorer implant fixation, and greater revision risk. It is these more difficult clinical scenarios that require research to evaluate more advanced treatment approaches. Such treatments can include osteogenic or antimicrobial implant coatings, allo-or autogenous cellular or tissue-based approaches, local and systemic drug delivery, surgical approaches. Regarding implantrelated approaches, most experimental and numerical models do not generally impose conditions that represent mechanical instability at the implant interface, or recalcitrant healing. Many treatments will work well in forgiving settings, but fail in complex human settings with disease, bone loss, or previous surgery. Ethical considerations mandate that we justify and limit the number of animals tested, which restricts experimental permutations of treatments. Numerical models provide flexibility to evaluate multiple parameters and combinations, but generally need to employ simplifying assumptions. The objectives of this paper are to (a) to highlight the importance of mechanical, material, and surgical features to influence implant-bone healing, using a selection of results from two decades of coordinated experimental and numerical work and (b) discuss limitations of such models and the implications for research reproducibility. Focusing model conditions toward the clinical scenario to be studied, and limiting conclusions to the conditions of a particular model can increase clinical relevance and research reproducibility.

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Wave front migration of endothelial cells in a bone-implant interface

Cited by 9 publications

References 43 publications

Low dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface in vitro

Low dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface in vitro

Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants

Experimental and Numerical Models of Complex Clinical Scenarios; Strategies to Improve Relevance and Reproducibility of Joint Replacement Research

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