Waveguide biosensor with integrated detector array for tuberculosis testing

Abstract

A label-free immunoassay using a local evanescent array coupled ͑LEAC͒ biosensor is reported. Complementary metal oxide semiconductor chips with integrated photoconductor arrays are used to detect an antibody to a M. tuberculosis protein antigen, HspX. The metrology limits of the LEAC sensor using dc and ac measurement systems correspond to average film thicknesses of 28 and 14 pm, respectively. Limits of detection are 87 and 108 pm, respectively, for mouse immunoglobulin G antibody patterning and antigen detection.

Development of a multianalyte optical sol–gel biosensor for medical diagnostic

“…Though similar label-free photonic platforms have been developed from silicon technology based on CMOS fabrication techniques for the detection of biological molecules [13,14], the main difference and novelty of our study consist of the employed materials, fabrication technology and the possibility to control the sensitivity of the biosensor platform by depositing a HRIL on top of the sensing areas.…”

Clinical immunosensing of tuberculosis CFP-10 antigen in urine using interferometric optical fiber array

“…In previous attempts to develop a breakthrough technique for TB monitoring, a variety of advanced biosensing tools have been explored, including quartz crystal microbalance (QCM) [6,7], piezoelectric crystal-based sensors [8,9], reflectometric interference spectroscopy [10], and waveguide biosensor [11]. We have also explored to develop clinical diagnostic sensors using surface plasmon resonance (SPR) [12][13][14][15].…”

Fiber based optofluidic biosensors

“…[1][2][3][4] Indeed, medical diagnosis and biotechnology progresses are strongly dependent on the development of the next generation of detection tools, which, ideally, would allow the reliable detection of very low amounts of biological species in various environments. In addition to these characteristics, sensing devices would also be easy to use and would present a rapid response.…”