Wavelength dependency of cataracts in albino mice following chronic exposure

Development of Light Dissemination in the Rat Lens after in vivo Exposure to Radiation in the 300-nm Wavelength Region

“…Several studies have been published on UVR-evoked struc tural changes in the lens [4][5][6][7][8], An action spectrum has been established for cataract development after exposure to UVR [9]. In that study, the threshold dose at a certain wavelength was defined as the lowest dose evoking macroscopically visible structural alteration, as judged with the slitlamp micro scope, within 24 h for permanent lenticular opacities and within 48 h for transient ones.…”

Banning children and youth under the age of 18 years from commercial tanning facilities

“…In vivo and ex vivo acute studies on mammalian lens (Pitts et al, 1977;Merriam et al, 2000;Oriowo et al, 2001) and a chronic in vivo study (Jose and Pitts, 1985) have indicated that the UVB part of the solar spectrum is most likely to be responsible for any long term effects that solar UVR has on the lens. There is also epidemiological evidence that solar UVR exposure results in ocular melanoma, especially from a study in Australia (Vajdic et al, 2002) that showed that choroid and ciliary body melanoma were positively associated with time outdoors on weekdays with OR up to 1.8 (95% CI 1.1 -2.8) and p = 0.01 for trend.…”

Geometrical Assessment of Ocular Exposure to Envirmmental UV Radiation -Implications for Ophthalmic Epidemiology

“…Action spectra (revealing the relative hazard of each wavelength) can only be obtained from the laboratory studies, and these have shown that anterior cortical and posterior subcapsular cataract can be produced by intense exposure delivered over a period of days [3][4][5].…”

“…Although some studies have concluded (and it has long been argued) that exposure of the human eye to UVR plays an etiologic role in the development of ocular diseases, including cataract [1][2][3][4][5][6][7][8], this role in cataractogenesis has been questioned by others [9][10][11][12]. Although photokeratitis is unquestionably caused by UVR reflection from the snow [12][13][14][15][16][17][18][19], pterygium and droplet keratopathies are less clearly related to UVR exposure 12,20).…”