Wavelet-based multifractal analysis of dynamic infrared thermograms to assist in early breast cancer diagnosis

Gerasimova, E. I.; Audit, Benjamin; Roux, Stéphane; Khalil, André; Гилева, О. С.; Argoul, Françoise; Naimark, Oleg; Arnéodo, A.

doi:10.3389/fphys.2014.00176

Cited by 73 publications

(61 citation statements)

References 45 publications

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“…During the past 30 years, the CWT was used for biological applications, on both 1D signals and 2D images [75,83,84,[93][94][95][96][97][98][99][100][101][102][103][104][105][106][107]. As far as 1D signals are concerned, the CWT was applied to AFM force curves collected from single living plant cells [39], living hematopoietic stem cells [36,45] and to AFM fluctuation signals to characterize the passive microrheology of living myoblasts [108].…”

Section: A4 Mechanical Indentation Experiments and Fics Recordingmentioning

confidence: 99%

A minimal rupture cascade model for living cell plasticity

et al. 2018

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Under physiological and pathological conditions, cells experience large forces and deformations that often exceed the linear viscoelastic regime. Here we drive CD34 + cells isolated from healthy and leukemic bone marrows in the highly nonlinear elasto-plastic regime, by poking their perinuclear region with a sharp AFM cantilever tip. We use the wavelet transform mathematical microscope to identify singular events in the force-indentation curves induced by local rupture events in the cytoskeleton (CSK). We distinguish two types of rupture events, brittle failures likely corresponding to irreversible ruptures in a stiff and highly cross-linked CSK and ductile failures resulting from dynamic cross-linker unbindings during plastic deformation without loss of CSK integrity. We propose a stochastic multiplicative cascade model of mechanical ruptures that reproduces quantitatively the experimental distributions of the energy released during these events, and provides some mathematical and mechanistic understanding of the robustness of the log-normal statistics observed in both brittle and ductile situations. We also show that brittle failures are relatively more prominent in leukemia than in healthy cells suggesting their greater fragility.

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Section: A4 Mechanical Indentation Experiments and Fics Recordingmentioning

confidence: 99%

A minimal rupture cascade model for living cell plasticity

et al. 2018

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“…Medical applications of thermography are wide [6] and are most often used to investigate a temperature change revealing a possible pathology. These applications include among others the monitoring of skin temperature [7,8], the detection of breast cancer [9,10], skin cancer [11] and inflammation [12]. In the operating room, thermography was investigated for neurosurgical applications [13,14] and plastic breast reconstruction [4].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of microvascular free flaps following oropharyngeal reconstruction using infrared thermography: first clinical experiences

Just

Chalopin

Unger

et al. 2015

Eur Arch Otorhinolaryngol

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The aim of this study is to investigate static and dynamic infrared (IR) thermography for intra- and postoperative free-flap monitoring following oropharyngeal reconstruction. Sixteen patients with oropharyngeal reconstruction by free radial forearm flap were included in this prospective, clinical study (05/2013-08/2014). Prior ("intraop_pre") and following ("intraop_post") completion of the microvascular anastomoses, IR thermography was performed for intraoperative flap monitoring. Further IR images were acquired one day ("postop_1") and 10 days ("postop_10") after surgery for postoperative flap monitoring. Of the 16, 15 transferred free radial forearm flaps did not show any perfusion failure. A significant decreasing mean temperature difference (∆T: temperature difference between the flap surface and the surrounding tissue in Kelvin) was measured at all investigation points in comparison with the temperature difference at "intraop_pre" (mean values on all patients: ∆T intraop_pre = -2.64 K; ∆T intraop_post = -1.22 K, p < 0.0015; ∆T postop_1 = -0.54 K, p < 0.0001; ∆T postop_10 = -0.58 K, p < 0.0001). Intraoperative dynamic IR thermography showed typical pattern of non-pathological rewarming due to re-established flap perfusion after completion of the microvascular anastomoses. Static and dynamic IR thermography is a promising, objective method for intraoperative and postoperative monitoring of free-flap reconstructions in head and neck surgery and to detect perfusion failure, before macroscopic changes in the tissue surface are obvious. A lack of significant decrease of the temperature difference compared to surrounding tissue following completion of microvascular anastomoses and an atypical rewarming following a thermal challenge are suggestive of flap perfusion failure.

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“…Study of nonlinear dynamics of cell and cytoskeleton structures, objectification of cytological diagnosis of cancer (morphometry) were conducted using the original data of modulation interference microscopy analyzing the time series of phase thickness fluctuations [30][31][32] in the cross-sections of the nucleus, the nucleolus, cytoplasm. The method for the estimation of spatial temporal invariants (in terms of the Hurst scaling exponent) allowed the demonstration of the links of temporal correlations of finite-amplitude phase thickness fluctuation in terms of multi-and monofractality with the states of the normal and cancerous cells [33][34][35]. The MIM data correspond to three types of patterns: cell phase image (Fig.…”

Section: Laser Modulation Interference Microscopy Convergent Coherenmentioning

confidence: 99%

DNA Breathers and Cell Dynamics

Nikitiuk¹,

Korznikova²,

Dmitriev³

et al. 2019

Math.Biol.Bioinf.

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Molecular-morphological signs of oncogenesis can be linked to multiscale collective effects in molecular and cell ensembles. It was shown that nonlinear behavior of biological systems can be associated with the generation of characteristic collective modes representing the open states in molecular and cell organization as the mechanism of the coherent expression dynamics. The mechanical DNA model is developed to study the nonlinear dynamics of the helicoidal geometry DNA molecule. To construct the model of DNA the Peyrard-Bishop-Barbi approach has been applied. The analytical small localized solutions as the discrete breather and the antikink have been obtained by multiple scale expansion method for multicomponent lattices. The set of collective open states (breathers) in the molecular ensembles provides the collective expression dynamics to attract cells toward a few preferred global states. This result allows the formulation of the experimental strategy to analyze the qualitative changes in cell dynamics induced by mentioned collective modes. The biomechanical changes have been shown experimentally using the original data of Coherent Phase Microscopy analyzing the time series of phase thickness fluctuations. Study of the mechanical aspects of the behavior of single cells is a prerequisite for the understanding of cell functions in the case of qualitative changes in diseases affecting the properties of cells and tissues morphology to develop diagnostic and treatment design methodology.

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Wavelet-based multifractal analysis of dynamic infrared thermograms to assist in early breast cancer diagnosis

Cited by 73 publications

References 45 publications

A minimal rupture cascade model for living cell plasticity

A minimal rupture cascade model for living cell plasticity

Monitoring of microvascular free flaps following oropharyngeal reconstruction using infrared thermography: first clinical experiences

DNA Breathers and Cell Dynamics

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