“…Several PA de-noising methods have been demonstrated to enhance the SNR of the PA signals and/or images [7,8,9,10,11,12,13,14,15,16,17]. The de-noising has been studied for PACT [7,8,9,10,12,16,17] and PAM [11,14,15]. For most PACT de-noising, PA raw data (A-line signals) are usually de-noised first prior to im-age reconstruction [7,9,12].…”