Wc1c Development and Evaluation of the Schizophrenia Proneness Instrument, Adult Version (Spi-A)

Schultze‐Lutter, Frauke; Ruhrmann, Stephan; Picker, H.; Klosterkötter, Joachim

doi:10.1016/s0920-9964(06)70014-7

Cited by 189 publications

(210 citation statements)

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“…In both CHR individuals and controls, CHR criteria were assessed with the SOPS, 4 as well as the Diagnostic Interview of Personality Disorders, 21 and the 10 items from the Bonn Scale for the Assessment of Basic Symptoms that were identified as having high predictive validity for the development of psychosis 6,7 and are implemented in the Schizophrenia Proneness Instrument, Adult Version. 22 Inclusion criteria for the CHR individuals were age 13-35 and meeting diagnostic criteria as specified in table 1 (see online supplementary methods S1 for a detailed description of exclusion criteria). The study was approved by the local institutional review board committees at each institution, including Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Brigham and Women's Hospital, and written informed consent was obtained from all subjects.…”

Section: Participantsmentioning

confidence: 99%

White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study

Hohenberg

Pasternak

Kubicki³

et al. 2013

Schizophrenia Bulletin

103

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Background:The study of individuals at clinical high risk (CHR) for psychosis provides an important opportunity for unraveling pathological mechanisms underlying schizophrenia and related disorders. A small number of diffusion tensor magnetic resonance imaging (DTI) studies in CHR samples have yielded anatomically inconsistent results. The present study is the first to apply tract-based spatial statistics (TBSS) to perform a whole-brain DTI analysis in CHR subjects. Methods: A total of 28 individuals meeting CHR criteria and 34 healthy controls underwent DTI. TBSS was used for a group comparison of fractional anisotropy (FA), as well as axial, radial, and mean diffusivity (AD, RD, and MD). Conversion to psychosis was monitored during a mean follow-up period of 12.3 months. Results: The rate of conversion to psychosis was relatively low (4%). TBSS revealed increased MD in several clusters in the right hemisphere, most notably in the superior longitudinal fasciculus (SLF), posterior corona radiata, and corpus callosum (splenium and body). Increased RD was restricted to a smaller area in the posterior parietal lobe. Conclusion: We present further evidence that white matter microstructure is abnormal in CHR individuals, even in a sample in which the vast majority do not transition to psychosis over the following year. In accord with previous studies on CHR individuals and patients with early-onset schizophrenia, our findings suggest an important pathological role for the parietal lobe and especially the SLF. The latter is known to undergo particularly dynamic microstructural changes during adolescence and early adulthood, a critical phase for the development of psychotic illness.

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Section: Participantsmentioning

confidence: 99%

White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study

Hohenberg

Pasternak

Kubicki³

et al. 2013

Schizophrenia Bulletin

103

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“…19,20 Moreover, the basic symptom criteria, COPER and COGDIS, are partially overlapping, but delineate risk of potentially different imminence and specificity-sensitivity ratio. [21][22][23][24] Nevertheless, both sets of at-risk criteria were developed solely 21 or predominately in adult samples (age 16 and older). 18 Therefore, early detection and treatment of people with first signs of the emerging disorder, which is currently regarded as one promising strategy in fighting the devastating consequences of psychosis, 1 may face different or additional challenges in children and adolescents, compared with adults.…”

Section: 12mentioning

confidence: 99%

The Significance of At-Risk Symptoms for Psychosis in Children and Adolescents

2013

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The early detection and treatment of people at risk for psychosis is currently regarded as a promising strategy in fighting the devastating consequences of psychotic disorders. Currently, the 2 most broadly used sets of at-risk criteria, that is, ultra-high risk (UHR) and basic symptom criteria, were developed mainly in adult samples. We review the data regarding the presence and relevance of at-risk symptoms for psychosis in children and adolescents. The few existing studies suggest that attenuated psychotic symptoms (APS) and brief limited intermittent psychotic symptoms (BLIPS) do have some clinical relevance in young adolescents from the general population. Nevertheless, their differentiation from atypical psychotic symptoms or an emerging schizotypal personality disorder, as well as their stability and predictive accuracy for psychosis, are still unclear. Further, standard interviews for UHR criteria do not define a minimum age for the assessment of APS and BLIPS or guidelines as to when and how to include information from parents. APS and basic symptoms may be predictive of conversion to psychosis in help-seeking young adolescents. Nevertheless, the rate and timing, and thus the required observation time, need further study. Moreover, no study has yet addressed the issue of how to treat children and adolescents presenting with at-risk symptoms and criteria. Further research is urgently needed to examine if current at-risk criteria and approaches have to be tailored to the special needs of children and adolescents. A preliminary rationale for how to deal with at-risk symptoms for psychosis in clinical practice is provided. W W W La signification des symptômes à risque de psychose chez les enfants et les adolescentsLa détection et le traitement précoces des personnes à risque de psychose sont actuellement réputés constituer une stratégie prometteuse pour combattre les conséquences désastreuses des troubles psychotiques. À l'heure actuelle, les 2 ensembles les plus utilisés de critères à risque, c'est-à-dire, le risque ultra-élevé (RUE) et les critères des symptômes de base, ont été développés principalement pour des échantillons adultes. Nous examinons les données au regard de la présence et de la pertinence des symptômes à risque de psychose chez les enfants et les adolescents. Les quelques études existantes suggèrent que les symptômes psychotiques atténués (SPA) et les symptômes psychotiques brefs, limités et intermittents (BLIPS) ont une certaine pertinence clinique chez les jeunes adolescents de la population générale. Néanmoins, leur différenciation des symptômes psychotiques atypiques ou d'un trouble de la personnalité schizotypique naissant, ainsi que leur stabilité et leur exactitude à prédire la psychose sont encore indéfinies. De plus, les entrevues standards pour les critères RUE ne fixent pas d'âge minimum pour l'évaluation des SPA et des BLIPS, ni n'offrent de guides sur le moment et la manière d'inclure l'information des parents. Les SPA et les symptômes de base peuvent prédire une conversion à...

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“…Between August 2002 and April 2006, data were collected from 245 help-seeking patients (age [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] who met Ôultra-high riskÕ (UHR) and ⁄ or Ôcognitive disturbancesÕ (COGDIS) criteria and agreed to participate in the European Prediction of Psychosis Study, EPOS (22,23). EPOS is a European collaboration of six centers in four countries: Germany, Finland, the Netherlands, and England.…”

Section: Recruitmentmentioning

confidence: 99%

Cannabis use and age at onset of symptoms in subjects at clinical high risk for psychosis

Dragt

Nieman

Schultze‐Lutter

et al. 2011

Acta Psychiatr Scand

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on behalf of the EPOS group. Cannabis use and age at onset of symptoms in subjects at clinical high risk for psychosis.Objective: Numerous studies have found a robust association between cannabis use and the onset of psychosis. Nevertheless, the relationship between cannabis use and the onset of early (or, in retrospect, prodromal) symptoms of psychosis remains unclear. The study focused on investigating the relationship between cannabis use and early and high-risk symptoms in subjects at clinical high risk for psychosis. Method: Prospective multicenter, naturalistic field study with an 18-month follow-up period in 245 help-seeking individuals clinically at high risk. The Composite International Diagnostic Interview was used to assess their cannabis use. Age at onset of high risk or certain early symptoms was assessed retrospectively with the Interview for the Retrospective Assessment of the Onset of Schizophrenia. Results: Younger age at onset of cannabis use or a cannabis use disorder was significantly related to younger age at onset of six symptoms (0.33 < r s < 0.83, 0.004 < P < 0.001). Onset of cannabis use preceded symptoms in most participants.

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Wc1c Development and Evaluation of the Schizophrenia Proneness Instrument, Adult Version (Spi-A)

Cited by 189 publications

References 0 publications

White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study

White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study

The Significance of At-Risk Symptoms for Psychosis in Children and Adolescents

Cannabis use and age at onset of symptoms in subjects at clinical high risk for psychosis

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