anks to the availability of high-performance computers, in the last few years, Computational Fluid Dynamics (CFD) has been widely applied to simulate natural hazards in the field of environmental and civil engineering [1]. In order to explore different risk scenarios and potential risk-reduction options and to address hazard related uncertainty, the development of numerical models represents an important task in supporting emergency response agencies, water resource managers, insurance companies, and other decision-makers [2]. e application purpose of CFD modeling requires contextual attention to the output variables of predictive interest and their time and space scales, the level of accuracy required considering eventually real-time data assimilation, and computational efficiency demands [3,4]. e main aim of this special issue is to highlight the most recent advances in CFD modeling and its application related to water-related natural hazards and discusses future directions. Special focus is devoted to the modeling, handling of uncertainty, and the applications related to relevant natural hazard problems of practical and theoretical interest. A brief summary of all accepted papers is provided below.In the paper by Y. Shi et al., they have investigated, through the numerical CFD test, the influence of bed surface roughness on the flow structure in an open channel. In particular, they have developed a CFD meshless method, such as a weakly compressible smoothed particle hydrodynamics (WCSPH) [5], for open-channel turbulence simulation. e proposed rough bed model is based on the ghost boundary particles (GBPs) [6]; it uses wall function for a small-scale rough boundary. e results outperform the traditional mixed-length-based subparticle scale (SPS) turbulence model [7] by obtaining small numerical errors in the mainstream and near-surface region but it is found that errors varied widely for the inner region; the authors showed that the latter error is positively correlated with the channel bed slope and the equivalent roughness. On the basis of these results, the study proposes empirical formulae to calculate the ghost particle velocity under different hydraulic conditions using data mining.C. Zhen et al. have investigated the fatigue failure for trimaran ship, which is actually considered as a good alternative to monohulls in high-speed transportation and in naval applications [8]. In particular, they have presented a simplified fatigue analysis of trimaran cross-deck structure based on three-dimensional (3D) linear potential flow theory and global finite element (FE) analysis for wave loads and stress transfer functions calculation; at the same time, a stochastic spectral fatigue analysis is carried out considering Hindawi Mathematical Problems in Engineering Volume 2020, Article ID 4363095, 3 pages https://doi.org/10.1155/2020/4363095 the weighted wave heading factors. en, the authors have demonstrated the application of the proposed method by simulating the fatigue lives of a few hot spots. e outcome of the stu...