Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

Alsmadi, Osama; Al‐Rubeaan, Khalid; Mohamed, Gamal; Alkayal, Fadi; Al-Saud, Haya; Al-Saud, Nouran Abu; Al-Daghri, Nasser M.; Mohammad, Shahinaz; Meyer, Brian F.

doi:10.1186/1471-2350-9-72

Cited by 63 publications

(43 citation statements)

References 33 publications

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“…The allelic frequency of the rs7903146 in the Iranian population was higher than those reported in the other populations, except for Arab population [23]. The frequency of the T allele in the non-diabetic subjects of the present study was 34.4%, whereas it was 4.2, 26.1, 28.0, 29, 29.3, 30.4, and 37.2% in Japanese [19], Danish [24], Asian Indian [25], Dutch [12], and UK-resident South Asian [26], Palestinian [27], Icelandic [24], and Emirati populations [28], respectively.…”

Section: Discussioncontrasting

confidence: 67%

Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population

et al. 2011

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Diabetes is one of the most common and challenging health problems. Studies in several nations show that polymorphisms within the transcription factor 7-like 2 genes could be associated with type 2 diabetes (T2D). Therefore, a case-control study was conducted to find the association between SNP rs7903146 and T2D in our population. The study consists of 110 patients referring to clinic and 80 healthy controls randomly selected based on WHO guideline. DNA was extracted from blood and genotyped by PCR-RFLP with specific primers to amplify a fragment for restriction enzyme (RsaI). A chi-square test was calculated to compare the proportions of genotypes or alleles. Using a logistic regression model, the odds ratio for risk of developing T2D was calculated with and without adjustment for age, sex, and BMI. The frequency of the T allele of rs7903146 (C/T) polymorphism was significantly higher in diabetic subjects (47.3%) compared to that in normal subjects (34.4%). Logistic regression analysis of the rs7903146 polymorphism showed that the odds ratio was 3.71(95% CI: 1.43-9.56; P: 0.008) for the TT genotype and 1.26 (95% CI: 0.67-2.39; P: 0.516) for the CT genotype when compared with the CC genotype. Odds ratio adjusted for age, sex, and BMI have shown similar results. The results show that rs7903146 of TCF7L2 gene is an important susceptibility gene for T2D mellitus in the province of Isfahan, Iran. Our results support the recent findings that rs7903146 of TCF7L2 gene is an important genetic risk factor for the development of T2D in multiple ethnic groups.

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Section: Discussioncontrasting

confidence: 67%

Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population

et al. 2011

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“…These studies were supported by a lack of association between T2D and the TCF7L2 SNP rs7903146 and a marginal association of rs12255372 in a United Arab Emirates population (Saadi et al, 2008). In addition, there was no association of either SNP with Saudi Arabian diabetic patients (Alsmadi et al, 2008).…”

Section: Discussionmentioning

confidence: 91%

“…However, conflicting results have been reported in populations from China, Saudi Arabia, and the United Arab Emirates, as well as in the Native American population of North America (Guo et al, 2007;Alsmadi et al, 2008;Ren et al, 2008;Saadi et al, 2008). Moreover, although an association between the TCF7L2 SNPs rs7903146 and rs12255372 and T2D has been investigated in several studies of Caucasian populations, there have been relatively few studies of mixed populations, such as Brazilians (Marquezine et al, 2008;Franco et al, 2011;Barra et al, 2012;Furgeri et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

Barros¹,

Araujo-Neto²,

Lopes³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D. Herein, we analyzed the association of these SNPs with T2D in a population from northeastern Brazil. Our results showed that the genotype and allele frequencies in TCF7L2 rs7903146 and rs12255372 were similar in the patient and control groups (P > 0.05). In addition, the allele frequencies were not significantly associated with T2D risk [rs7903146: odds ratio (OR) = 0.95, 95% confidence interval (CI) = 0.52-1.76, P = 1.00, and rs12255372: OR = 1.38, 95%CI = 0.72-2.62, P = 0.41]. These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. However, our results may reflect the small number of subjects. Alternatively, these results may be attributable to specific ethnic effects, as most of the previously reported associations were demonstrated with predominantly European populations. To reach a definitive conclusion on the role of such gene variants for T2D in mixed populations, additional efforts are necessary to replicate this study with larger populations from areas with more ethnic heterogeneity.

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“…12 In addition, association between this polymorphism and type 2 diabetes has been well demonstrated in African Americans and in West Africans, 21,22 but data are less consistent in northern African populations. [23][24][25] Older age, BMI, and tacrolimus use were other significant independent risk factors in white patients. Steroid boluses, given for acute rejection episodes, also accounted for the risk for developing NODAT.…”

Section: Discussionmentioning

confidence: 99%

TCF7L2 Polymorphism Associates with New-Onset Diabetes after Transplantation

Ghisdal¹,

Baron

Meur

et al. 2009

Journal of the American Society of Nephrology

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New-onset diabetes after transplantation (NODAT) is a serious and frequent complication in transplant recipients. Whether NODAT shares the same susceptibility genes as type 2 diabetes is unknown. In this multicenter study, we genotyped 1076 white patients without diabetes at transplantation for 11 polymorphisms that associate with type 2 diabetes. We defined NODAT as a fasting plasma glucose Ն126 mg/dl on at least two occasions or de novo hypoglycemic therapy. We compared clinical and genetic factors between patients who developed NODAT within 6 mo of transplantation (n ϭ 118; incidence 11%) and patients without diabetes (n ϭ 958). In multivariate analysis, NODAT significantly associated with the following characteristics: TCF7L2 polymorphism (odds ratio [OR] 1.60 per each T allele; P ϭ 0.002), age (OR 1.03 per year; P Ͻ 0.001), body mass index at transplantation (OR 1.09 per unit; P Ͻ 0.001), tacrolimus use (OR 2.26; P Ͻ 0.001), and the occurrence of a corticoid-treated acute rejection episode (OR 2.78; P Ͻ 0.001). In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 diabetes in the general population, also associates with NODAT.

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Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

Cited by 63 publications

References 33 publications

Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population

Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

TCF7L2 Polymorphism Associates with New-Onset Diabetes after Transplantation

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