We focus on the existence and uniqueness of the three-dimensional Landau-Lifshitz-Bloch equation supplemented with the initial data in Besov space Ḃ 3 2 2,1 . Utilizing a new commutator estimate, we establish the local existence and uniqueness of strong solutions for any initial data in Ḃ 3 2 2,1 . When the initial data is small enough in Ḃ 3 22,1 , we obtain the global existence and uniqueness. Furthermore, we also establish a blow-up criterion of the solution to the Landau-Lifshitz-Bloch equation and then we prove the global existence of strong solutions in Sobolev space under a new condition based on the blow-up criterion.