Hip joint collapse is a very common health problem. Many cases need a joint replacement, so nano-polymeric composites are an ideal alternative solution. Due to its mechanical properties and wear resistance, HDPE might be considered a suitable alternative to frictional materials. The current research focuses on using hybrid nanofiller TiO2 NPs and nano-graphene with various loading compositions to evaluate the best loading amount. The compressive strength, modules of elasticity, and hardness were examined via experiments. The COF and wear resistance were evaluated via a pin-on-disk tribometer. The worn surfaces were analyzed based on 3D topography and SEM images. The HDPE samples with various compositions of 0.5%, 1.0%, 1.5%, and 2.0 wt.% filling content of TiO2 NPs and Gr (with a ratio of 1:1) were analyzed. Results revealed that hybrid nanofiller with a composition of 1.5 wt.% exhibits superior mechanical properties compared to other filling compositions. Moreover, the COF and wear rate decreased by 27.5% and 36.3%, respectively.