Wearable alcohol monitoring device with auto-calibration ability for high chemical specificity

Umasankar, Yogeswaran; Jalal, Ahmed Hasnain; González, Pablo J.; Chowdhury, Mustahsin; Alfonso, Alejandro; Bhansali, Shekhar

doi:10.1109/bsn.2016.7516287

Cited by 15 publications

(7 citation statements)

References 14 publications

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“…It lacks wireless communication interfaces and a formal validation studio is not provided. In [ 20 , 21 ], multimodal electrochemical methods are implemented for different applications using complex and custom-made sensors; such as improving the specificity of ethanol detection in multiple analyte and low concentration solutions. Furthermore, in these works, users must acquire specific skills, in order to operate the equipment.…”

Section: Introductionmentioning

confidence: 99%

A COTS-Based Portable System to Conduct Accurate Substance Concentration Measurements

Aznar-Poveda

López-Pastor

Otero

2018

Sensors

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Traditionally, electrochemical procedures aimed at determining substance concentrations have required a costly and cumbersome laboratory environment. Specialized equipment and personnel obtain precise results under complex and time-consuming settings. Innovative electrochemical-based sensors are emerging to alleviate this difficulty. However, they are generally scarce, proprietary hardware and/or software, and focused only on measuring a restricted range of substances. In this paper, we propose a portable, flexible, low-cost system, built from commercial off-the-shelf components and easily controlled, using open-source software. The system is completed with a wireless module, which enables the transmission of measurements to a remote database for their later processing. A well-known PGSTAT100 Autolab device is employed to validate the effectiveness of our proposal. To this end, we select ascorbic acid as the substance under consideration, evaluating the reliability figure and obtaining the calibration curves for both platforms. The final outcomes are shown to be feasible, accurate, and repeatable.

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Section: Introductionmentioning

confidence: 99%

A COTS-Based Portable System to Conduct Accurate Substance Concentration Measurements

Aznar-Poveda

López-Pastor

Otero

2018

Sensors

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“…In addition, temperature cycle testing was performed to show stability of the sensor for variation of temperature cycles for a range of 25-40 °C with ~7.6% variability on a second-order polynomial fit. Kim et al 22 Gao et al 23 Umasankar et al 24 This Work…”

Section: Discussionmentioning

confidence: 92%

A Four-Channel Electrical Impedance Spectroscopy Module for Cortisol Biosensing in Sweat-Based Wearable Applications

Sankhala

Muthukumar²,

Prasad

2018

SLAS Technology

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A four-channel electrochemical impedance spectroscopy (EIS) analyzer module has been demonstrated on flexible chemi-impedance sensors fabricated with gold electrodes for wearable applications. The module can perform time division multiplexed (TDM) impedance measurements on four sensors at 1 kHz. In this work, we characterize the system for the detection of cortisol in an ultralow volume (1-3 µL) of perspired human sweat, sensor performance, and effects during continuous cortisol dosing and with pH and temperature variations expected on the surface of the skin that would be representative of use conditions as seen by a wearable device. Detection of cortisol was shown for concentrations of 1 pg/mL to 200 ng/mL in both synthetic and perspired human sweat, and output response reported as a change in impedance with varying cortisol concentrations. Continuous dose testing was performed to demonstrate the stability of the sensors over prolonged periods of operation for cortisol concentrations within the physiologically relevant range of 10-200 ng/mL reported in human sweat. Temperature and pH effects testing was performed for pH range 4-8 and in a temperature chamber for the clinical range reported on the surface of human skin: 25-40 °C. The cortisol sensor demonstrated stability of operation with 7.58% variability under these conditions.

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“…For human subject measurements, a miniaturized potentiostat [30,31] in a wearable wristband recorded electrical currents associated with the sensor and simultaneous temperature readings associated with a thermistor at 0.2 Hz with a 12-bit ADC. Values were transmitted to a corresponding smartphone application.…”

Section: Methodsmentioning

confidence: 99%

Wearable Enzymatic Alcohol Biosensor

Lansdorp

Ramsay

Hamid

et al. 2019

Sensors

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Transdermal alcohol biosensors have the ability to detect the alcohol that emanates from the bloodstream and diffuses through the skin. However, previous biosensors have suffered from long-term fouling of the sensor element and drift in the resulting sensor readings over time. Here, we report a wearable alcohol sensor platform that solves the problem of sensor fouling by enabling drift-free signals in vivo for up to 24 h and an interchangeable cartridge connection that enables consecutive days of measurement. We demonstrate how alcohol oxidase enzyme and Prussian Blue can be combined to prevent baseline drift above 25 nA, enabling sensitive detection of transdermal alcohol. Laboratory characterization of the enzymatic alcohol sensor demonstrates that the sensor is mass-transfer-limited by a diffusion-limiting membrane of lower permeability than human skin and a linear sensor range between 0 mM and 50 mM. Further, we show continuous transdermal alcohol data recorded with a human subject for two consecutive days. The non-invasive sensor presented here is an objective alternative to the self-reports used commonly to quantify alcohol consumption in research studies.

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Wearable alcohol monitoring device with auto-calibration ability for high chemical specificity

Cited by 15 publications

References 14 publications

A COTS-Based Portable System to Conduct Accurate Substance Concentration Measurements

A COTS-Based Portable System to Conduct Accurate Substance Concentration Measurements

A Four-Channel Electrical Impedance Spectroscopy Module for Cortisol Biosensing in Sweat-Based Wearable Applications

Wearable Enzymatic Alcohol Biosensor

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