Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Lee, Hyunjae; Song, Changyeong; Hong, Yong Seok; Kim, Min Sung; Cho, Hye Rim; Kang, Thomas H.‐K.; Shin, Kwang‐Soo; Choi, Seung Hong; Hyeon, Taeghwan; Kim, Dae‐Hyeong

doi:10.1126/sciadv.1601314

Cited by 933 publications

(574 citation statements)

References 53 publications

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“…Skin-mounted electronics have provided new routes for advanced wearable diagnostic/therapeutic solutions. [137][138][139][140][141][142][143][144][145][146] However, significant challenges still remain for the wearable displays that can show the monitored data from the wearable sensors to the user in real time. One of the major challenges for ideal wearability is the thickness and stiffness of the conventional flexible displays.…”

Section: Wearable Quantum Dot Displaysmentioning

confidence: 99%

Flexible quantum dot light-emitting diodes for next-generation displays

et al. 2018

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In the future electronics, all device components will be connected wirelessly to displays that serve as information input and/or output ports. There is a growing demand of flexible and wearable displays, therefore, for information input/output of the nextgeneration consumer electronics. Among many kinds of light-emitting devices for these next-generation displays, quantum dot light-emitting diodes (QLEDs) exhibit unique advantages, such as wide color gamut, high color purity, high brightness with low turn-on voltage, and ultrathin form factor. Here, we review the recent progress on flexible QLEDs for the next-generation displays. First, the recent technological advances in device structure engineering, quantum-dot synthesis, and high-resolution full-color patterning are summarized. Then, the various device applications based on cutting-edge quantum dot technologies are described, including flexible white QLEDs, wearable QLEDs, and flexible transparent QLEDs. Finally, we showcase the integration of flexible QLEDs with wearable sensors, micro-controllers, and wireless communication units for the next-generation wearable electronics.

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Section: Wearable Quantum Dot Displaysmentioning

confidence: 99%

Flexible quantum dot light-emitting diodes for next-generation displays

et al. 2018

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“…9 In addition, the low thermal conductivity of ITO can lead to slow heating and cooling rates. 10 Because of these disadvantages of ITO, the use of low-dimensional and stretchable conductive materials, such as graphene, [11][12][13] CNTs, 14,15 metal nanowires (mNWs) 7,[16][17][18] and serpentine patterns of metal films, 19,20 has been studied extensively in the search for stretchable heaters. However, carbon-based, transparent heaters require high operation voltages because of their relatively high R s values without doping (4~250 Ω per sq), which can degrade their power efficiency.…”

Section: Introductionmentioning

confidence: 99%

Rapid production of large-area, transparent and stretchable electrodes using metal nanofibers as wirelessly operated wearable heaters

et al. 2017

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A rapidly growing interest in wearable electronics has led to the development of stretchable and transparent heating films that can replace the conventional brittle and opaque heaters. Herein, we describe the rapid production of large-area, stretchable and transparent electrodes using electrospun ultra-long metal nanofibers (mNFs) and demonstrate their potential use as wirelessly operated wearable heaters. These mNF networks provide excellent optoelectronic properties (sheet resistance of~1.3 Ω per sq with an optical transmittance of~90%) and mechanical reliability (90% stretchability). The optoelectronic properties can be controlled by adjusting the area fraction of the mNF networks, which also enables the modulation of the power consumption of the heater. For example, the low sheet resistance of the heater presents an outstanding power efficiency of 0.65 W cm − 2 (with the temperature reaching 250°C at a low DC voltage of 4.5 V), which is~10 times better than the properties of conventional indium tin oxide-based heaters. Furthermore, we demonstrate the wireless fine control of the temperature of the heating film using Bluetooth smart devices, which suggests substantial promise for the application of this heating film in next-generation wearable electronics.

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“…In glucose detection, biofluids, such as blood, urine, saliva, and sweat, might be used as biomarkers for clinical monitoring of diabetes 44 . The normal glucose concentrations in biofluids are 4-8 mM in blood 45 , , K + , ascorbic acid, glucose, and glycine).…”

Section: Resultsmentioning

confidence: 99%

“…The volume of the test droplet was 2 µL. Error bars refer to the standard deviation of three replicates 0.5-2.8 mM in urine 46 , 0.008-0.21 mM in saliva 45 and 0.005-1 mM in sweat, which is correlated with the blood glucose concentration 44 . Glucose homeostasis refers to the maintenance of a stable glucose level within the body by the balancing of insulin and glucagon.…”

Section: Resultsmentioning

confidence: 99%

Naked-eye point-of-care testing platform based on a pH-responsive superwetting surface: toward the non-invasive detection of glucose

et al. 2018

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Herein, we demonstrate a contact angle (CA)-based naked-eye point-of-care testing platform with rapid pH-responsive superwettability that can switch between superhydrophilic and superhydrophobic properties for quantitative biosensing. The CA of the droplet on the pH-responsive surface approached~0°at pH 1 and conversely reached 161.4°± 6.2°at pH 13. We realized the sensitive detection of the pH, urea, and glucose by monitoring the changes in the CA. The traditional invasive diagnosis of diabetes causes pain and brings the risk of infections, such as acquired immune deficiency syndrome (AIDS), hepatitis B, hepatitis C, and syphilis, to the user. To address this issue, we implemented a method for the non-invasive diagnosis of diabetes in human saliva and urine, which avoided the significant drawbacks mentioned above. The accuracy of this method was demonstrated by comparing the results with those from commercial glucometers and theoretical calculations. Interestingly, we successfully monitored glucose levels in sweat before, during, and after cycling. The sensing performance was barely influenced by the temperature, elevation, and droplet color, illustrating promise for expansion to hundreds of millions of potential customers, especially those with color blindness or color weakness. Given its low cost, lack of instruments, and rapid response (within 1 s), this strategy might overcome the limitations of the mechanical stability and durability of superwettable materials and thus might extend the industrial-scale application of bioinspired superwettable systems.

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Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Abstract: A sweat-based glucose monitoring device with transdermal drug delivery is developed for noninvasive diabetes treatment.

Cited by 933 publications

References 53 publications

Flexible quantum dot light-emitting diodes for next-generation displays

Flexible quantum dot light-emitting diodes for next-generation displays

Rapid production of large-area, transparent and stretchable electrodes using metal nanofibers as wirelessly operated wearable heaters

Naked-eye point-of-care testing platform based on a pH-responsive superwetting surface: toward the non-invasive detection of glucose

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