Wearable Light Therapy: A Wearable Photobiomodulation Patch Using a Flexible Red‐Wavelength OLED and Its In Vitro Differential Cell Proliferation Effects (Adv. Mater. Technol. 5/2018)

Abstract

Based on a flexible red‐wavelength organic light‐emitting diode (OLED), a wearable photobiomodulation patch for wound healing is demonstrated by Kyoung‐Chan Park, Kyung Cheol Choi, and co‐workers in article number https://doi.org/10.1002/admt.201700391. The patch excellently promotes in vitro wound healing. It also has a reasonable operation reliability, flexibility, and offers low‐temperature operation, so it can provide wide application irrespective of location and time attached to the human body.

Fibronectin-Enriched Interface Using a Spheroid-Converged Cell Sheet for Effective Wound Healing

“…Because light energy can be transferred to designated tissue or cells intact owing to its remote and penetrative properties, light has attracted significant attention as a strong tool for future biomedical technology. − Light has also been adopted as a cell preconditioning tool because it induces the angiogenic secretive properties of cells by inducing ROS signaling. ,, ROS signaling in light therapy is achieved by ROS generation, following stimulation of cytochrome c oxidase in the mitochondria, which results in HIF-1α upregulation. , Because light can induce phototoxicity through excessive ROS generation, where ROS production exceeds elimination resulting in loss of ROS homeostasis, it is important to strike balance between ROS signaling and phototoxicity in light therapy. Therefore, excessive ROS generation normally induces apoptotic activity of the cells. , Therefore, the light dose must be adjusted so that the amount of ROS generated falls below the toxic range. − …”