Wearable Transcranial Ultrasound System for Remote Stimulation of Freely Moving Animal

Kim, Evgenii; Anguluan, Eloise; Kum, Jeungeun; Sanchez-Casanova, Jorge; Park, Tae Young; Kim, Jae Gwan; Kim, Hyung-Min

doi:10.1109/tbme.2020.3038018

Cited by 17 publications

(16 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stimulation of a mouse/rat stroke model with TUS reduces apoptosis by promoting microglial polarization and modulating interleukin (IL)-10 signaling in the ischemic brain, apoptosis and induction of brain-derived neurotrophic factor (BDNF) to promote neurorehabilitation after cerebral ischemia. The above results show that both ultrasound protection and ultrasound therapy can have a protective effect on the nerves of stroke [52], [77]- [79]. In this study, we found that both ultrasound prevention and therapy significantly reduced the number of head scratches.…”

Section: Discussionsupporting

confidence: 64%

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Yao

Chen

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

View full text Add to dashboard Cite

This study sought to systematically evaluate the prophylactic and therapeutic effects of low-intensity transcranial ultrasound stimulation on migraine in rats. We used video recordings to assess the head scratching behavior and laser speckle contrast imaging to record the changes in cerebral blood flow velocity of freely moving rats in a healthy group, migraine group, migraine group with ultrasound prevention, and migraine group with ultrasound therapy. Results demonstrated that (1) head scratching during migraine attacks in rats was accompanied by an increase in cerebral blood flow; (2) both ultrasound prevention and therapy significantly reduced the number of head scratches but did not reduce the cerebral blood flow velocity; and (3) the number of head scratches in the ultrasound stimulation groups was not affected by the auditory effect. These results reveal that low-intensity ultrasound has the potential to be used clinically in the prevention and therapeutic treatment of migraine.

show abstract

Section: Discussionsupporting

confidence: 64%

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Yao

Chen

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

View full text Add to dashboard Cite

show abstract

“…Thus, we do not recommend using a DC over 50% or a pulse duration longer than 10 ms. Sub-megahertz ultrasound frequency selected in this study offered excellent transmission through the rat skull. Based on the acoustic map and location of transducers, along with acoustic simulation from our previous work (Kim et al, 2020), the developed system produced an ultrasound field presumably concentrated within the motor cortex.…”

Section: Discussionmentioning

confidence: 99%

“…The above limitations motivated us to develop a wireless, low-cost system for concurrent LIPUS-mediated bilateral stimulation on rats. In the previous work, we developed a portable transcranial ultrasound system for remote brain stimulation of freely behaving animals (Kim et al, 2020). However, the system was designed to drive only a single ultrasound transducer, thus offering single-target stimulation.…”

Section: Introductionmentioning

confidence: 99%

Development of a wireless ultrasonic brain stimulation system for concurrent bilateral neuromodulation in freely moving rodents

et al. 2022

Self Cite

View full text Add to dashboard Cite

Bilateral brain stimulation is an important modality used to investigate brain circuits and treat neurological conditions. Recently, low-intensity pulsed ultrasound (LIPUS) received significant attention as a novel non-invasive neurostimulation technique with high spatial specificity. Despite the growing interest, the typical ultrasound brain stimulation study, especially for small animals, is limited to a single target of sonication. The constraint is associated with the complexity and the cost of the hardware system required to achieve multi-regional sonication. This work presented the development of a low-cost LIPUS system with a pair of single-element ultrasound transducers to address the above problem. The system was built with a multicore processor with an RF amplifier circuit. In addition, LIPUS device was incorporated with a wireless module (bluetooth low energy) and powered by a single 3.7 V battery. As a result, we achieved an ultrasound transmission with a central frequency of 380 kHz and a peak-to-peak pressure of 480 kPa from each ultrasound transducer. The developed system was further applied to anesthetized rats to investigate the difference between uni- and bilateral stimulation. A significant difference in cortical power density extracted from electroencephalogram signals was observed between uni- and bilateral LIPUS stimulation. The developed device provides an affordable solution to investigate the effects of LIPUS on functional interhemispheric connection.

show abstract

“…In this study, the in-house focused ultrasound transducer was designed as described in the previous work [19]. The transducer was made based on 3 MHz PZT-4 ceramics with a diameter of 6 mm.…”

Section: Trans-spinal Focused Ultrasound Neuromodulationmentioning

confidence: 99%

Trans-Spinal Focused Ultrasound Stimulation Selectively Modulates Descending Motor Pathway

Kim

Kum

Kim

2022

IEEE Trans. Neural Syst. Rehabil. Eng.

Self Cite

View full text Add to dashboard Cite

Compared to current non-invasive methods utilizing magnetic and electrical means, focused ultrasound provides greater spatial resolution and penetration depth. Despite the broad application of ultrasound stimulation, there is a lack of studies dedicated to the investigation of acoustic neuromodulation on the spinal cord. This study aims to apply focused ultrasound on the spinal cord to modulate the descending pathways in a non-invasive fashion. The application of trans-spinal focused ultrasound (tsFUS) was examined on the motor deficit mouse model. tsFUS was achieved using a single-element focused ultrasound transducer operating at 3 MHz. The sonication was performed on anesthetized 6 week-old mice targeting T12 and L3 vertebrae. The effect was analyzed by comparing electromyography responses from the hindlimb induced by electrical stimulation of the motor cortex. Further, the mouse model with the Harmaline-induced essential tremor was selected to investigate the potential clinical application of tsFUS. The safety was verified by histological assessment. Sonication at the T12 area inhibited motor response, while sonication over the L3 region provided signal enhancement. Sonication of T12 of the ET mouse also showed the ability of ultrasound to suppress tremors. Meanwhile, the histological examination did not show any abnormalities with the highest applied acoustic pressure. In this work, a non-invasive motor signal modulation was achieved using tsFUS. Moreover, the results showed the ability of focused ultrasound to manage tremors in a safe manner. This study provides a stepping stone for the trans-spinal application of focused ultrasound to motor-related disorders.

show abstract

Wearable Transcranial Ultrasound System for Remote Stimulation of Freely Moving Animal

Cited by 17 publications

References 50 publications

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Development of a wireless ultrasonic brain stimulation system for concurrent bilateral neuromodulation in freely moving rodents

Trans-Spinal Focused Ultrasound Stimulation Selectively Modulates Descending Motor Pathway

Contact Info

Product

Resources

About