Wearable wristband-based electrochemical sensor for the detection of phenylalanine in biofluids

Parrilla, Marc; Vanhooydonck, Andres; Watts, Regan; Wael, Karolien De

doi:10.1016/j.bios.2021.113764

Cited by 51 publications

(28 citation statements)

References 32 publications

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“…This is crucial for performing decentralized measurements such as point‐of‐care diagnostics [ 31 ] and self‐diagnosing with wearable devices. [ 32,33 ]…”

Section: Introductionmentioning

confidence: 99%

“…This is crucial for performing decentralized measurements such as point-of-care diagnostics [31] and self-diagnosing with wearable devices. [32,33] Polymers have emerged as perfect partners to develop the different components of 3D analytical platforms made on paper substrates. Polymers with a vast array of physicochemical properties and smart functions are commercially available, thus providing endless possibilities for development (Figure 1).…”

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confidence: 99%

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Polymer Components for Paper‐Based Analytical Devices

Campo

Vaquer

Rica

2022

Adv Materials Technologies

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In recent years, paper has become an essential substrate material for developing different types of sensors, from wearable devices to single‐use test strips and biosensors. In parallel, a polymer‐based toolbox has emerged in order to add additional functions to these paper‐based analytical devices. In this article, examples are compiled from the recent literature showing microfluidic systems based on printing impermeable polymer barriers with different methods as well as the implementation of electrochemical, fluorescent, and colorimetric polymer‐based transducers in paper‐based analytical platforms. Externally actuated or dissolvable polymer valves and reservoirs, analyte concentrators, and separation devices, as well as polymer‐based recognition elements (molecularly imprinted polymers) printed on paper substrates are also reviewed. The search has revealed a plethora of possibilities for developing complex lab‐on‐chip devices implementing different polymer‐based components in them. The ability of patterning these polymers with common printing methods that do not require specialized facilities paves the way for mass producing this kind of advanced paper‐based analytical device.

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“…This is crucial for performing decentralized measurements such as point‐of‐care diagnostics [ 31 ] and self‐diagnosing with wearable devices. [ 32,33 ]…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Polymer Components for Paper‐Based Analytical Devices

Campo

Vaquer

Rica

2022

Adv Materials Technologies

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“…Among wearable sweat sensors, paper-based sweat sensors have attracted significant research interest owing to their low cost, easy fabrication, short detection time, and convenient sampling process. − Cellulose-based paper substrates contain rich hydrophilic groups, such as carboxyl and hydroxy groups, and numerous capillaries. Therefore, they do not require additional pumps for fluid flow along designed directions. , In addition, paper-based sensors can filter some unwanted interferences (i.e., particulate matter and dust in liquids) that may affect the detection performance of sweat sensors.…”

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confidence: 99%

Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

et al. 2023

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Wearable sweat sensors, a product of the development of flexible electronics and microfluidic technologies, can continuously and noninvasively monitor abundant biomarkers in human sweat; however, sweat interferences, such as sebum, can reduce sensor reliability and accuracy. Herein, for the first time, the influence of sebum on the potentiometric response of an all-solidstate pH sensor was studied, and the obtained experimental results show that sebum mixed in sweat can decrease the potential response of the sensor and the slope of its calibration curve. A paper-based sandwich-structured pH sensor that can filter the sebum mixed in sweat was proposed based on commonly used oilcontrol sheets. Moreover, the hydrophilic properties, microstructure, and microfluidic performance of the sensor were investigated. The detection performance of the paper-based sandwich-structured pH sensor was comprehensively evaluated in terms of calibration in the presence of sebum and potentiometric response upon the addition of sebum. Furthermore, the antiinterference ability of the sensor was evaluated using different analytes under various deformation conditions. On-body trials were conducted to verify the performance, and their results showed that the proposed sensor can filter over 90% of the sebum in sweat, significantly enhancing sensor reliability and accuracy. Additionally, microfluidic channels could be simply fabricated using a scissor and paper, obviating the need for complex micromachining processes, such as photolithography and laser engraving. Overall, this work illustrates the influence of sebum on the detection performance of traditional potentiometric wearable sensors and paves the way for their development for real-world applications.

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“…(2) Mild phenylketonuria is associated with patients with L-Phe blood concentrations between 600 and 1200 μM.(3) Patients are considered to have classic phenylketonuria if their L-Phe blood concentrations are above 1200 µM. 2,8,10…”

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confidence: 99%

“…(3) Patients are considered to have classic phenylketonuria if their L-Phe blood concentrations are above 1200 µM. 2,8,10…”

mentioning

confidence: 99%

An ECL sensor combined with a paper electrode for the determination of phenylalanine

Torul

Kayiş

BoyacÎ¹

et al. 2022

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Wearable wristband-based electrochemical sensor for the detection of phenylalanine in biofluids

Cited by 51 publications

References 32 publications

Polymer Components for Paper‐Based Analytical Devices

Polymer Components for Paper‐Based Analytical Devices

Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH

An ECL sensor combined with a paper electrode for the determination of phenylalanine

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