Weaving Enzymes with Polymeric Shells for Biomedical Applications

Li, Meng; Blum, Nicholas Thomas; Wu, Jiayingzi; Lin, Jing; Huang, Peng

doi:10.1002/adma.202008438

Cited by 23 publications

(22 citation statements)

References 127 publications

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“…[ 4 ] Zinc ion batteries (ZIBs) reached the top priority due to the merits of outstanding theoretical capacity (820 mAh g −1 ), low redox potential (−0.76 V vs standard hydrogen electrode), and an abundance of Zn metal. [ 5,6 ] However, some key issues including metal corrosion, complex side reaction, and uncontrollable Zn dendrite caused by Zn metal anode redox chemistry still hinder the practical application of ZIBs. [ 7–10 ]…”

Section: Introductionmentioning

confidence: 99%

Semi‐Immobilized Ionic Liquid Regulator with Fast Kinetics toward Highly Stable Zinc Anode under −35 to 60 °C

et al. 2022

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Aqueous zinc ion batteries (ZIBs) have been extensively investigated as a next‐generation energy storage system due to their high safety and low cost. However, the critical issues of irregular dendrite growth and intricate side reactions severely restrict the further industrialization of ZIBs. Here, a strategy to fabricate a semi‐immobilized ionic liquid interface layer is proposed to protect the Zn anode over a wide temperature range from −35 to 60 °C. The immobilized SiO2@cation can form high conjugate racks that can regulate the Zn2+ concentration gradient and self‐polarizing electric field to guarantee uniform nucleation and planar deposition; the free anions of the ILs can weaken the hydrogen bonds of the water to promote rapid Zn2+ desolvation and accelerate ion‐transport kinetics simultaneously. Because of these unique advantages, the cycling performance of the symmetric Zn batteries is greatly enhanced, evidenced by a cycling life of 1800 h at 20 mA cm−2, and a cycle lifespan of 2000 h under a wide temperature window from −35 to 60 °C. The efficiency of this semi‐immobilizing strategy is well demonstrated in various full cells including pouch cells, showing high performance at large current (20 A g−1) and wide temperatures with extra‐long cycles up to 80 000 cycles.

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Section: Introductionmentioning

confidence: 99%

Semi‐Immobilized Ionic Liquid Regulator with Fast Kinetics toward Highly Stable Zinc Anode under −35 to 60 °C

et al. 2022

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“…The application of enzymes to modern industrial processes[ 1 , 2 , 3 ] and therapeutics[ 4 , 5 ] demands progress in research aimed at tailoring enzyme functionality and developing methodologies for their integration into devices. [ 6 , 7 , 8 , 9 , 10 ] Like most non‐fibrous proteins, enzymes are inherently fragile ex situ, hindering their use, for example, in commercial catalysis where recyclability is desired. [ 11 , 12 , 13 ] Thus, immobilization on, or within, solids is employed as a strategy to enhance enzyme stability in catalysis, biomedical science and biosensing applications.…”

Section: Introductionmentioning

confidence: 99%

Combining a Genetically Engineered Oxidase with Hydrogen‐Bonded Organic Frameworks (HOFs) for Highly Efficient Biocomposites

et al. 2022

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Enzymes incorporated into hydrogen‐bonded organic frameworks (HOFs) via bottom‐up synthesis are promising biocomposites for applications in catalysis and sensing. Here, we explored synthetic incorporation of d‐amino acid oxidase (DAAO) with the metal‐free tetraamidine/tetracarboxylate‐based BioHOF‐1 in water. N‐terminal enzyme fusion with the positively charged module Zbasic2 strongly boosted the loading (2.5‐fold; ≈500 mg enzyme gmaterial−1) and the specific activity (6.5‐fold; 23 U mg−1). The DAAO@BioHOF‐1 composites showed superior activity with respect to every reported carrier for the same enzyme and excellent stability during catalyst recycling. Further, extension to other enzymes, including cytochrome P450 BM3 (used in the production of high‐value oxyfunctionalized compounds), points to the versatility of genetic engineering as a strategy for the preparation of biohybrid systems with unprecedented properties.

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“…For instance, the protein (enzyme) stabilization by single enzyme nanocapsules (SENs) has enticed substantial research attention. In this approach, the protein (especially enzyme) is encapsulated in a thin polymer, prepared either by in situ polymerization or wrapping a preformed, permeable, and thin polymer around it [150][151] [152]. For example, glucose oxidase (GOX) nanocapsules are prepared by a two-tier polymerization approach to obtain an active and stable biocatalyst.…”

Section: Challenges and Perspectives For Ace2-based Biosensing Systemsmentioning

confidence: 99%

Angiotensin-converting enzyme 2-based biosensing modalities and devices for coronavirus detection

Gul¹,

Zhai²,

Zhong³

et al. 2022

Preprint

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Rapid and cost-effective diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become a critical and valuable weapon for the coronavirus disease 2019 (COVID-19) pandemic response. SARS-CoV-2 invasion is primarily mediated by human angiotensin-converting enzyme 2 (hACE2). Recent developments in ACE2-based SARS-CoV-2 detection modalities accentuate the potential of this natural host-virus interaction for developing point-of-care (POC) COVID-19 diagnostic tools and devices. Although research on harnessing ACE2 for SARS-CoV-2 detection is in its infancy, some interesting biosensing devices have been developed, showing the commercial viability of this intriguing new approach. The exquisite performance of the reported ACE2-based COVID-19 biosensors provides opportunities for researchers to develop rapid detection tools suitable for testing at points of entry, workplaces, or congregate scenarios in order to effectively implement pandemic control and management plans. However, to be considered as an emerging approach, the rationale for ACE2-based biosensing needs to be critically and comprehensively surveyed and discussed. Herein, we review the current status of ACE2-based detection methods, the signal transduction principles in ACE2 biosensors and the development trend in the future. We discuss the challenges to development of ACE2-biosensors and delineate prospects for their use, along with recommended solutions and suggestions

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Weaving Enzymes with Polymeric Shells for Biomedical Applications

Cited by 23 publications

References 127 publications

Semi‐Immobilized Ionic Liquid Regulator with Fast Kinetics toward Highly Stable Zinc Anode under −35 to 60 °C

Semi‐Immobilized Ionic Liquid Regulator with Fast Kinetics toward Highly Stable Zinc Anode under −35 to 60 °C

Combining a Genetically Engineered Oxidase with Hydrogen‐Bonded Organic Frameworks (HOFs) for Highly Efficient Biocomposites

Angiotensin-converting enzyme 2-based biosensing modalities and devices for coronavirus detection

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