In the digital age, information literacy, defined as the ability to effectively identify information needs, access needed information, and evaluate and use information, is a crucial skill set for both individuals and organizations. Therefore, understanding the relationships between information literacy, creativity, and work performance could not only help enterprises recognize the importance of information literacy and its influence on the workplace, but also provide educators with guidance for planning related training programs. This empirical study explores the relationships between self-efficacy in information literacy, creativity and work performance. The findings show that (1). self-efficacy in defining information needs, self-efficacy in evaluating information and self-efficacy in using information can significantly positively affect creativity; (2). creativity can significantly positively affect work performance; and, (3). creativity mediates the association between self-efficacy in information literacy and work performance. Implications based on the findings are also discussed.