from GR cultivars are equal or nearly equal to those from non-GR cultivars (Reddy and Whiting, 2000). Re-Management inputs that maximize economic return from the search has shown that pre-emergent herbicides usually early soybean [Glycine max (L.) Merr.] production system have not been evaluated fully. Field studies were conducted near Stoneville, do not adversely affect GR soybean vs. non-GR culti-MS (33؇26 N lat.), to determine the effect of rotating maturity group vars (Gonzini et al., 1999; Nelson and Renner, 1999; (MG) IV and V glyphosate [N-(phosphonomethyl)glycine]-resistant Webster et al., 1999;Reddy, 2001a). This means that (GR) and non-GR cultivars on weed populations, soybean seed yields, residual herbicides can be used on plantings of GR and net returns from nonirrigated plantings. Eight management syscultivars to prevent early-season weed competition in tems, each containing a MG IV or MG V GR or non-GR cultivar grown situations where a timely application of glyphosate is continuously or in rotation with each other, and two weed managenot possible (Corrigan and Harvey, 2000). Glyphosate ment treatments [pre-emergent followed by postemergent weed manapplied at labeled rates does not affect GR soybean agement (PRE ϩ POST) and postemergent-only weed management growth and yield (Nelson and Renner, 1999; Reddy (POST)] were grown each year. Glyphosate-resistant cultivars using et al., 2000; Elmore et al., 2001). Timely applications of POST-only glyphosate was the most economical system each year. Maturity group effect on yield and net return resulted from weather glyphosate to sensitive weed species in GR soybean differences during reproductive development. Rotating GR and non-need no supplementation with nonglyphosate herbi-GR cultivars had no consistent effect on weed populations and no cides to achieve maximum weed control (Gonzini et al., significant effect on yield or net return in this 4-yr study. Using GR 1999; Webster et al., 1999; Corrigan and Harvey, 2000;cultivars resulted in net returns that were greater than those from Reddy and Whiting, 2000;Reddy, 2001a). All of these non-GR cultivars. These results indicate that production systems using advantages should translate to a reduction in manageeither GR or non-GR cultivars grown continuously or in rotation ment decisions for producers related to weed control in with each other in this region can be utilized effectively with no effect soybean when GR cultivars are used in the ESPS. on weed population shifts or reductions in seed yield and net return.The continued and increasing use of glyphosate in crop production is being associated with weed resistance to glyphosate (Powles et al.