Wegener Granulomatosis and Alveolar Proteinosis in a 32-Year-Old Female

Pulmonary Alveolar Proteinosis in a 67-Year-Old Woman with Wegener’s Granulomatosis

“…Immunosuppressive medications reported to be associated with PAP include corticosteroids, leflunomide, sirolimus, tacrolimus, cyclosporine, azathioprine and busulfan [4][5][6][7][9][10][11][12] . To our knowledge, this case is the first to report an association of mycophenolate mofetil with PAP.…”

“…PAP has been associated with autoimmune disorders such as rheumatoid arthritis, IgA nephropathy, multiple sclerosis and dermatomyositis, as well as in a patient with smooth muscle antibodies 3,11,15,16 . There is one prior case report of WGassociated PAP 12 . Most of these patients are also on immunosuppressive medications; the reported patient with WG was on cyclophosphamide and prednisone at the time of diagnosis of PAP.…”