Wegener's Granulomatosis Presenting as Unilateral Parotid Enlargement

Chegar, Burke E.; Kelley, Richard T.

doi:10.1097/00005537-200410000-00010

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…Patients with hyperlipidemia are considered to be at high risk to develop lipids disorders that are associated with immune system deficiency, promoting manifestations including fatty degeneration of parotid parenchyma and parotid duct enlargement [3–6]. Various diseases could be associated with parotid gland swelling, such as primary or secondary Sjogren Syndrome (SS), diabetes mellitus, Wegener's granulomatosis, sialadenitis, and infections [7–9]. …”

Section: Introductionmentioning

confidence: 99%

Morphological Changes of Parotid Gland in Experimental Hyperlipidemia

Daskala

Tesseromatis

2011

International Journal of Dentistry

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Objective. The aim of this study was to investigate the role of hyperlipidemia in the microstructure of parotid gland and its possible amelioration through statin treatment on Wistar rats. Methods. Forty Wistar rats (111.06 ± 3.36 g) were divided into 4 groups (A1, A2 controls, B1, B2 experimental). Groups A1 and A2 consumed normal cereal rodents diet during the experimental hyperlipidemic mixture. The A2 and B2 were treated with simvastatin (Zocor) 40 mg/kg/daily p.o. for 3 months. Results. Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased. The histological findings demonstrated changes in the parotid gland morphology of the B1 and B2, such as the presence of chronic inflammation, fibrosis, lipocytes, and foci of lymphocytic infiltration. Conclusions. The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

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Section: Introductionmentioning

confidence: 99%

Morphological Changes of Parotid Gland in Experimental Hyperlipidemia

Daskala

Tesseromatis

2011

International Journal of Dentistry

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“…The clinical appearance of WG involvement of the salivary glands (especially the parotid and submandibular glands) varies and it might be difficult to differentiate the appearances of WG from other differential diagnoses, such as malignant neoplasm, abscess, sarcoidosis, tuberculosis and infection based on imaging evaluation including 18F-FDG PET/CT scan [13][14][15][16][17].…”

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confidence: 99%

Fluorine-18-fluorodeoxyglucose PET/CT rare finding of a unique multiorgan involvement of Wegener's granulomatosis

Almuhaideb¹,

Syed²,

Iordanidou³

et al. 2011

BJR

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ABSTRACT. Wegener's granulomatosis (WG) is an uncommon autoimmune disorder, which mainly involves the blood vessels, kidneys and respiratory tract. We report an interesting case of WG with unusual multiorgan involvement in a young male who presented with a short history of right-sided otalgia, nasal obstruction and a right parotid mass. His initial CT and MRI scans showed a large parotid mass with features suggestive of malignancy with bilateral cavitating pulmonary nodules suggesting metastatic disease. The imaging-based differential diagnosis was squamous cell carcinoma or adenoid cystic carcinoma. The microscopic findings on ultrasound-guided biopsy of the parotid mass were, surprisingly, those of acute necrotising granulomatous inflammation with some features suggestive of a vasculitic process. A multidisciplinary team discussion and further investigation resulted in the additional findings of haematuria, raised erythrocyte sedimentation rate and positive serum cytoplasmic antineutrophil cytoplasmic antibody test, which led to the diagnosis of WG. Subsequently, the patient developed acute urinary retention owing to gross prostatic enlargement related to further disease involvement, which was confirmed with a positive biopsy. Fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT scan showed disease distribution at the right maxillary sinus/nasal cavity, right parotid, mediastinum, lungs and prostate. To our knowledge, this is the first reported 18F-FDG PET/CT case with multiorgan involvement in a single WG patient. The patient has improved both clinically and on imaging after appropriate treatment with immunosuppressive therapy and steroids. Although 18F-FDG PET/CT imaging did not actually alter the management of this patient, it can help to establish the disease distribution and guide the biopsy.

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“…As Chegar and Kelley [11] showed, WG can rarely appear with parotid salivary gland involvement. As seen in our case, granulomatous diseases (particularly tuberculosis) should be considered in parotitis cases that are resistant to medical treatment, especially those with fistulized nonhealing wounds.…”

Section: Discussionmentioning

confidence: 94%

Wegener granulomatosis in parotid fistula and bilateral nasal mass

Demir¹

2017

Kulak Burun Bogaz Ihtis Derg

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Wegener's Granulomatosis Presenting as Unilateral Parotid Enlargement

Cited by 25 publications

References 22 publications

Morphological Changes of Parotid Gland in Experimental Hyperlipidemia

Morphological Changes of Parotid Gland in Experimental Hyperlipidemia

Fluorine-18-fluorodeoxyglucose PET/CT rare finding of a unique multiorgan involvement of Wegener's granulomatosis

Wegener granulomatosis in parotid fistula and bilateral nasal mass

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