Weight gain during treatment course of allogenic hematopoietic stem cell transplantation in patients with hematological malignancies affects treatment outcome

Johansen, Silje; Blomberg, Björn; Vo, Anh Khoi; Wendelbo, Øystein; Reikvam, Håkon

doi:10.1016/j.jcyt.2022.08.006

Cytotherapy

2022

DOI: 10.1016/j.jcyt.2022.08.006

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Weight gain during treatment course of allogenic hematopoietic stem cell transplantation in patients with hematological malignancies affects treatment outcome

Silje Johansen

Björn Blomberg

Anh Khoi Vo

et al.

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Cited by 3 publications

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The prognostic impact of C‐reactive protein and albumin in patients diagnosed with acute myeloid leukaemia

Skar,

Wendelbo,

Reikvam

2024

eJHaem

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BackgroundAcute myeloid leukaemia (AML) is an aggressive and heterogeneous malignant disease. Patient age, comorbidities and disease‐specific genetic abnormalities are recognized as primary determinants of treatment response. Recent years have elucidated the significance of nutritional status and inflammation across various malignancies, including AML, in influencing treatment outcomes.AimsTo assess the prognostic value of the C‐reactive protein‐albumin ratio (CAR) and the Glasgow Prognostic Score (GPS) in predicting overall survival (OS) rates among patients diagnosed with AML.Material and methods189 AML patients receiving standard cytarabine and anthracycline‐based induction treatment were included. Baseline demographic, clinical and laboratory data were collected, and treatment outcomes and survival were registered for all patients.ResultsNo significant association between CAR and prognosis among AML patients was found, even in subgroup analyses. Hypoalbuminemia was an independent predictor of poor survival among all patients (OS 28 vs. 16 months; p < 0.02). Patients with a GPS of 0 or 1 demonstrated superior OS compared to those with a GPS of 2 (median OS 28 vs. 16 months, respectively; p = 0.015). Results remained consistent among patients ≥ 60 years (median OS 15 vs. 6 months; p = 0.020).ConclusionHeightened inflammation and suboptimal nutritional status correlate with unfavourable prognoses in AML patients. Such insights hold the potential for guiding clinical decision‐making, offering easily accessible prognostic information for the induction treatment of eligible AML patients.

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The prognostic impact of C‐reactive protein and albumin in patients diagnosed with acute myeloid leukaemia

Skar,

Wendelbo,

Reikvam

2024

eJHaem

View full text Add to dashboard Cite

show abstract

Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality

Reikvam¹,

Bruserud²,

Hatfield³

2023

Transplantation and Cellular Therapy

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Metabolic syndrome prevalence and impact on outcomes in patients with chronic graft-versus-host disease

Zhao,

Pirsl,

Steinberg

et al. 2023

Bone Marrow Transplant

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Weight gain during treatment course of allogenic hematopoietic stem cell transplantation in patients with hematological malignancies affects treatment outcome

Cited by 3 publications

References 20 publications

The prognostic impact of C‐reactive protein and albumin in patients diagnosed with acute myeloid leukaemia

The prognostic impact of C‐reactive protein and albumin in patients diagnosed with acute myeloid leukaemia

Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality

Metabolic syndrome prevalence and impact on outcomes in patients with chronic graft-versus-host disease

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