Weight reduction can decrease circulating soluble lectin-like oxidized low-density lipoprotein receptor–1 levels in overweight middle-aged men

Nomata, Yasuhiro; Kume, Noriaki; Sasai, Hiroyuki; Katayama, Yasutomi; Nakata, Yoshio; Okura, Tomohiro; Tanaka, Kiyoji

doi:10.1016/j.metabol.2009.06.018

Cited by 23 publications

(25 citation statements)

References 33 publications

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“…It has been shown that patients with metabolic syndrome are at high-risk of developing many disorders. The sLOX-1 levels have been shown to significantly increase in atherosclerotic plaque instability [23], diabetes mellitus [19], obesity [18], and are positively correlated with a reduction in body weight [24]. Association with coronary artery disease and metabolic disorders also suggested sLOX-1 as a biomarker for early detection of acute coronary syndrome [25,26].…”

Section: Discussionmentioning

confidence: 99%

Soluble lectin-like oxidized low density lipoprotein receptor-1 in metabolic syndrome

2015

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Background: Serum levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) reflect increases in LOX-1 receptor expression associated with inflammation and metabolic disorders. Objectives: To examine sLOX-1 levels in metabolic syndrome and association of sLOX-1 with classical risk factors, and with metabolic syndrome, a clustering of metabolic disorders associated with cardiovascular risk factors. Methods: We selected 148 serum samples from patient participants with metabolic syndrome and 206 samples from patients with non-metabolic syndrome as controls, using the modified National Cholesterol Educational Program Adult Treatment Panel III (NCEP-ATP III) criteria. Results: Levels of sLOX-1 were increased significantly in participants with metabolic syndrome (P < 0.001). Serum sLOX-1 was positively associated with body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and total cholesterol, but negatively associated with high-density lipoprotein cholesterol. Analysis of serum sLOX-1 for metabolic syndrome showed 99.03% specificity and 100% sensitivity. The area under the receiver operating characteristic curve was 0.998 (95%CI 0.996-1.001, P < 0.001). A univariate analysis showed sLOX-1 was significantly correlated with metabolic syndrome, but was not after adjustment for sex, age, blood pressure, and BMI. Multivariate regression analysis found that being overweight (82.3; 95%CI 10.7−631.9), hyperglycemia (1.1; 95%CI 1.1−1.2), and hypertriglyceridemia (1.1; 95%CI 1.0−1.1) were significantly correlated with metabolic syndrome. HDL cholesterol was a protective factor (0.96; 95%CI: 0.93−0.99). Conclusions: Serum sLOX-1 is a suitable biomarker for diagnosis of metabolic syndrome. However, univariate and multivariate analysis suggested that sLOX-1 may be a modulating factor, and not an independent risk factor.

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Section: Discussionmentioning

confidence: 99%

Soluble lectin-like oxidized low density lipoprotein receptor-1 in metabolic syndrome

2015

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“…A 12-week weight reduction program involving a well-balanced diet and exercise also decreased serum sLOX-1 levels in 32 overweight middle-aged Japanese men [59] . In this study, decreases in serum levels of sLOX-1 were associated with decreases in body weight, BMI, body fat mass, and subcutaneous fat area.…”

Section: Lifestyle and Other Determinants Related To Lox-1mentioning

confidence: 87%

LOX-1 in atherosclerotic disease

Sawamura

Wakabayashi

Okamura

2015

Clinica Chimica Acta

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“…In addition, the findings from our previous studies demonstrated that a 12-week supervised aerobic exercise training programme was effective for altering lipids in overweight/obese middle-aged men 10,11) ; however, a previous study showed no acute effect of exercise on blood pre-heparin LPL concentrations 12) . Therefore, in this study, training effects on blood preheparin LPL concentrations were examined.…”

Section: Introductionmentioning

confidence: 82%

Twelve-Week Jogging Training Increases Pre-Heparin Serum Lipoprotein Lipase Concentrations in Overweight/Obese Middle-Aged Men

Miyashita

Eto

Sasai

et al. 2010

JAT

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Aim: Enhancement of lipoprotein lipase (LPL) activity through drug administration has been shown to increase pre-heparin serum LPL concentrations; however, pre-heparin serum LPL responses to exercise training have not been determined. The present study was undertaken to investigate the effects of 12 weeks of supervised aerobic exercise training on pre-heparin serum LPL concentrations in overweight/obese men. Methods: Fifteen overweight/obese middle-aged men were assigned to one of two 12-week supervised exercise interventions: a walking group (eight participants gradually increasing brisk walking to 60 min/day 3 days a week) or a jogging group (seven participants gradually increasing jogging to 60 min/day 3 days a week). All participants maintained ad libitum diets. Blood samples were collected at baseline and immediately after 12 weeks. The primary outcome was pre-heparin serum LPL. Results: Pre-heparin serum LPL concentrations were increased in the jogging group after 12 weeks compared with the baseline values (mean SEM: 37.6 4.7 vs. 51.0 6.6 ng/mL, respectively, p 0.033). In the walking group, pre-heparin serum LPL concentrations remained unchanged after 12 weeks. Conclusions: This study demonstrates that 12 weeks of jogging training increases pre-heparin serum LPL concentrations in overweight/obese middle-aged men. J Atheroscler Thromb, 2010; 17:21-29.Key words; Aerobic exercise, Training, Pre-heparin serum lipoprotein lipase, Lipid metabolism nous injection of heparin, LPL is detached from the endothelium surface and released in blood. Alternatively, a small fraction of LPL protein naturally (i.e., without intravenous injection of heparin) detached from the endothelial surface is detectable in serum by a sensitive enzyme-linked immunoassay 2,3) . Although pre-heparin serum LPL is catalytically inactive and its physiological role is not fully understood, previous cross-sectional studies have shown that pre-heparin serum LPL concentrations were considerably lower in patients with type 2 diabetes 4) and hyperlipidaemia 5) compared with healthy individuals. A previous cross-sectional study also reported an inverse relationship between pre-heparin serum LPL concentration and serum triacylglycerol concentration in both healthy individuals and hyperlipidaemic patients 6)

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Weight reduction can decrease circulating soluble lectin-like oxidized low-density lipoprotein receptor–1 levels in overweight middle-aged men

Cited by 23 publications

References 33 publications

Soluble lectin-like oxidized low density lipoprotein receptor-1 in metabolic syndrome

Soluble lectin-like oxidized low density lipoprotein receptor-1 in metabolic syndrome

LOX-1 in atherosclerotic disease

Twelve-Week Jogging Training Increases Pre-Heparin Serum Lipoprotein Lipase Concentrations in Overweight/Obese Middle-Aged Men

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