Weight reduction effects of a black soy peptide supplement in overweight and obese subjects: Double blind, randomized, controlled study

Abstract

The present study determined the effect of black soy peptide supplementation on body weight and body fat in overweight/obese subjects. In a double-blind controlled trial, participants (n = 80) were randomized to either soy peptide supplementation (the test group) or to a placebo (the placebo group). Sixty-four people completed the study, and anthropometric parameters, serum inflammatory markers, and leptin and lipid profiles were measured. After 6 weeks, the test group (n = 35) had significant reductions in body weight (p = 0.003) and body mass index (BMI) (p = 0.004), body fat mass (p = 0.038). After 12 weeks, they also had significant reductions in body weight (p < 0.001), BMI (p < 0.001), body fat percentage (p = 0.002), and body fat mass (p = 0.001). However, these significances were not observed in the placebo group (n = 29). In addition, net changes in body weight and body fat mass in the test group were significantly bigger than those in the placebo group after 12 weeks. Leptin levels were significantly reduced in the test groups (p = 0.047), but were not observed in the placebo group (p = 0.323). Interestingly, the subjects with weight reductions ≥1kg in the test group had greater reductions in circulating leptin levels (p = 0.002). Additionally, fasting insulin levels were significantly reduced in the test groups. The conclusion is that black soy peptide supplementation may be beneficial for body weight control in overweight/obese subjects.

Anthocyanin Rich-Black Soybean Testa Improved Visceral Fat and Plasma Lipid Profiles in Overweight/Obese Korean Adults: A Randomized Controlled Trial

“…9,10 Recent studies have examined the safety and antioxidative and anticarcinogenic effects of black soybean pigment, but the antiobesity effects of anthocyanins in black soybean have not yet been shown. [11][12][13][14] We observed antiobesity and lipid-lowering effects in anthocyanin-rich black soybeans that were consistent with those of previously published studies. 15 We conducted an in vitro study before performing a randomized clinical trial and found that black soybean testa extracts (BBT) inhibited fat accumulation and related factors such as peroxisome proliferator-activated receptor gamma (PPARc) and CCAAT enhancer binding protein alpha (C/EBPa) in adipocytes induced from preadipocytes.…”

Obesity-Related Metabolomic Analysis of Human Subjects in Black Soybean Peptide Intervention Study by Ultraperformance Liquid Chromatography and Quadrupole-Time-of-Flight Mass Spectrometry

“…Details on the general characteristics of all volunteers subjects, which were recruited by public advertisement and the diet intervention protocol for obesity by BSP, are provided in our previous paper [15]. The study subjects were 34 overweight/obese subjects aged 19–65, who were interested in losing weights.…”

“…Serum leptin levels were found to be significantly reduced in these research participants [15]. BSPs used for the experiment are analogues of doenjang (fermented soybean paste) peptides.…”

Effects of black soy peptide supplementation on blood pressure and oxidative stress: a randomized controlled trial

“…The control group (n ¼ 46) received pouches containing casein that had a similar appearance to that of the black soy peptide tablet. Kwak et al 11 conducted a pilot study in 32 subjects with fasting glucose X90 mg dl À1 dl; black soy peptide (1.5 g, 3.0 g or 4.5 g, dose-dependently) and placebo was randomly provided to study participants. From this study, high dose of the black soy peptide group (4.5 g day À1 ) showed a greater tendency of reduction in body weight (1.1±0.92 kg) than the other groups (data unpublished).…”