Weight, Shape, and Body Composition Changes at Menopause

Fenton, Anna

doi:10.4103/jmh.jmh_123_21

Cited by 30 publications

(31 citation statements)

References 37 publications

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“…For perimenopausal women, knee pain may be accompanied by hip pain, which is altering gait or ambulation endurance 31 . This, in turn, can decrease activity levels and result in weight gain and increased central adiposity 32 . Knee pain may be accompanied by vasomotor symptoms including hot flashes and night sweats, which are impairing sleep 33,34 .…”

Section: Discussion/observationsmentioning

confidence: 99%

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Knee osteoarthritis in midlife women: unique considerations and comprehensive management

2022

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Objective: Knee osteoarthritis (KOA) is a common musculoskeletal condition that particularly afflicts women in menopause. The purpose of this review is to describe the pathophysiology and treatment considerations for this subset of the population.Methods: Medline/PubMed indexed articles related to the pathophysiology, diagnosis, and management of osteoarthritis were included in this narrative review.Results and Conclusion: Menopause has a multitude of effects that affect KOA, including hormonal shifts; loss of bone mineral density, muscle mass, and tendon strength; and changes to pain perception. Here, we discuss how a practitioner can assess the factors that are known to worsen KOA symptoms, including postural (spine, pelvic, and knee) alignment and functional muscle strength. The development of an effective exercise program is at the forefront of management. Optimizing other lifestyle factors including nutrition and sleep are particularly important in this patient population. Sleep disturbance from vasomotor symptoms can also increase perception of knee pain, for which pharmacologic options such as gabapentin or duloxetine may be pursued. In total, these interventions have large ramifications in decreasing pain and increasing function through improved range of motion, body composition, and walking speed in women with KOA.

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Section: Discussion/observationsmentioning

confidence: 99%

“…Menopause is a time associated with weight gain, particularly increased truncal adiposity 32 . In overweight and obese patients, weight loss is a critical component of knee OA treatment.…”

Section: Treatmentmentioning

confidence: 99%

Knee osteoarthritis in midlife women: unique considerations and comprehensive management

2022

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“…On the other hand, physical parameters, such as middle-Age, raised HR (evident by palpitations due to increased vasomotor response to hormonal imbalance [33]), BMI (gained weight towards obesity [34]), high systolic and diastolic BP (as essential hypertension settles in the body as age advances [35]), irregular synthesis and secretion of estradiol and progesterone (which is a measure of the hypothalamus-pituitaryovarian axis [36]), TSH (often is elevated to compensate for the increased demand of thyroxin in the body [37]), HbA1c (rises as type-2 diabetes settles down in the body [38]), and cortisol (a measure of the hypothalamus-pituitary-adrenal axis is often elevated due to the increment of stress [39]) have direct or indirect relationships with the perimenopause stage in the women's life.…”

Section: Rationale Of Parameter-selectionmentioning

confidence: 99%

Towards Phenotyping Suppressed Anger in Perimenopausal Women with Lyfas Biomedical Application: A Comprehensive Diagnostic Reliability Study

Chattopadhyay¹,

Das²

2022

J. Nanotech. Diagn. Treat.

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Biomedical applications are gaining popularity in decoding human emotion. Anger causes sympathetic overdrive and is a normal emotion, which is either expressed or kept suppressed. Suppressed anger (SA) is a major health issue often causing serious cardiometabolic and mental diseases due to cardiac autonomic neuropathy (CAN), where the sympathovagal homeostasis is compromised to compensate for it. Lyfas is a smartphone-based biomedical application that captures CAN through short (120 sec) heart rate variability (HRV) and its associated cardiovascular optical biomarkers (COBs). This paper attempts to diagnose SA with the help of Lyfas COBs and a few important physical parameters in a cohort of Indian perimenopausal women (N=415; case 205 and control 210), who suffer from mood dysregulation due to the depletion of natural estradiol (E2) in the brain. The clinical Anger Scale (CAS), a gold-standard anger assessment tool is taken into consideration as a reference scale. The strength of correlations of each COB and physical parameter with CAS and its reliability is calculated using Spearman’s correlation and Bland-Altman’s reliability assessment, respectively. The paper concludes that COBs such as SDNN, RMSSD, and LF/HF along with physical parameters (BMI) are hallmark biomarkers for SA phenotypes with 71% of accuracy, 74% of j-statistics, as well as 92% of precision. Early diagnosis of SA with Lyfas would facilitate early treatment, and thereby improve the quality of life.

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“…Menopause is also associated with weight gain and worsening body composition with a shift from gynoid to android fat distribution [ 2 ]. Although the responsible mechanisms have not been completely clarified, changes in energy homeostasis due to aging; estrogen deficiency; sleep disturbances; changes in adipokines; gut hormones; and gut microbiota seem to play a role in weight gain and the worsening of body composition during menopause [ 3 ]. It has been estimated that approximately 70% of women of perimenopausal age are overweight or obese, both of which are associated with excess morbidity and mortality [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Postmenopausal Women with or without Obesity

Leanza

Conte

Cannata

et al. 2023

Cells

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Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative stress states in postmenopausal women with or without obesity. Body composition was assessed via DXA, while lipid peroxidation and total hydroperoxides were measured in patient’s serum samples via thiobarbituric-acid-reactive substances (TBARS) and derivate-reactive oxygen metabolites (d-ROMs) assays, respectively. Accordingly, 31 postmenopausal women were enrolled: 12 with obesity and 19 of normal weight (mean (SD) age 71.0 (5.7) years). Doubled levels of serum markers of oxidative stress were observed in women with obesity in women with obesity compared to those of normal weight (H2O2: 32.35 (7.3) vs. 18.80 (3.4) mg H2O2/dL; malondialdehyde (MDA): 429.6 (138.1) vs. 155.9 (82.4) mM in women with or without obesity, respectively; p < 0.0001 for both). Correlation analysis showed that both markers of oxidative stress increased with an increasing body mass index (BMI), visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. In conclusion, obesity and visceral fat are associated with a greater increase in oxidative stress in postmenopausal women, possibly increasing cardiometabolic and cancer risks.

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Weight, Shape, and Body Composition Changes at Menopause

Cited by 30 publications

References 37 publications

Knee osteoarthritis in midlife women: unique considerations and comprehensive management

Knee osteoarthritis in midlife women: unique considerations and comprehensive management

Towards Phenotyping Suppressed Anger in Perimenopausal Women with Lyfas Biomedical Application: A Comprehensive Diagnostic Reliability Study

Oxidative Stress in Postmenopausal Women with or without Obesity

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