Weighted Zernike defocus coefficient of treatment zone is a meaningful indicator for myopia control efficacy of Ortho-K lenses

Fan, Yuzhuo; Li, Yan; Wang, Kai; Qu, Jia; Zhao, Mingwei

doi:10.1186/s40662-022-00296-0

Cited by 8 publications

(3 citation statements)

References 31 publications

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“…The mean pupil size in the 19 eyes in this study, based on the topographic maps, was 4.15 mm, although the map readings did not show good repeatability. The average photopic pupil diameter varied from 3 to 4 mm in previous studies ( 53 , 55 ). According to another previous study, the average difference in pupil diameters between scotopic and photopic conditions was 1.5 mm ( 47 ).…”

Section: Discussionmentioning

confidence: 78%

High myopia control is comparable between multifocal rigid gas-permeable lenses and spectacles

Yu,

Zhuo,

Song

et al. 2023

Front. Med.

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PurposeOcular pathology may be reduced by slowing myopia progression. The purpose of this study was to evaluate the potential of a novel custom-designed rigid gas permeable (RGP) contact lens to control high myopia by comparing the efficacy of multifocal RGP lenses and single-vision spectacles for high myopia control.MethodsThe medical records of children fitted with spectacles or multifocal rigid gas-permeable lenses between January 2018 and May 2020 were retrospectively reviewed. Children (5–17 years) with non-cycloplegic spherical equivalent refraction of ≤ −6.00 D or spherical equivalent refraction > − 6.00 D with baseline axial length ≥ 26.5 mm, and astigmatism of ≥ −2.00 D were included. Axial length and refraction were measured at baseline, before fitting the participants with multifocal rigid gas-permeable lenses or spectacles, and at 1- and 2-year follow-up visits. Changes in axial length were compared between the groups.ResultsAmong the 77 children with 1-year follow-up data, the mean axial elongation was 0.20 ± 0.17 mm and 0.21 ± 0.14 mm in the multifocal rigid gas-permeable and control groups, respectively, without significant differences between groups (F = 0.004, p = 0.835). Among the 41 patients who completed 2 years of follow-up, the mean axial elongation values in the multifocal rigid gas-permeable and control groups were 0.21 ± 0.15 mm and 0.24 ± 0.13 mm, respectively, at the 1-year follow-up, and 0.37 ± 0.27 mm and 0.43 ± 0.23 mm, respectively, at the 2-year follow-up, without significant between-group differences at either time point (p = 0.224).ConclusionAxial length increased at a similar rate in both the control (spectacles) and multifocal rigid gas-permeable lens groups, suggesting that multifocal rigid gas-permeable lenses have no significant impact on controlling high myopia progression compared with spectacles.

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Section: Discussionmentioning

confidence: 78%

High myopia control is comparable between multifocal rigid gas-permeable lenses and spectacles

Yu,

Zhuo,

Song

et al. 2023

Front. Med.

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“…To calculate the TZ area (πr 2 ), the CSV files of the corneal sagittal height data were exported from the Sirius system at baseline and after one year of Ortho-K treatment. A customized specific MATLAB program was used to calculate the TZ area as outlined in a previous study [ 26 ]. A total of 256 points on the TZ border, defined as the points of transition from negative to positive values, were automatically extracted from the tangential difference map.…”

Section: Methodsmentioning

confidence: 99%

Long-term follow-up of changes in ocular biometric parameters in orthokeratology lens wearers with relatively large-scale axial length reduction

Tang

Chen

et al. 2023

Eye and Vis

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Background To investigate ocular biological characteristics for myopic children with axial length (AL) reduction during orthokeratology (Ortho-K) treatment and provide clinical clues for better myopia control effects. Methods Changes in ocular parameters and treatment zone (TZ) in 75 subjects who completed one-year Ortho-K treatment were retrospectively reviewed. The subjects were divided into two groups according to one-year AL change: the AL reduction group (n = 37) and the AL elongation group (n = 38). Univariate and multivariate regression analyses were performed to determine the association between TZ, ocular parameters, and AL change. Results There was no significant difference in baseline between the two groups (all P > 0.05). After one year of Ortho-K treatment, compared with those in the AL elongation group, children in the AL reduction group had a decreased anterior chamber depth (ACD) (P < 0.001), thickened crystalline lens thickness (CLT) (P = 0.002), thinned vitreous chamber depth (VCD) (P < 0.001) and smaller TZ (P = 0.03), but no difference in central corneal thickness (CCT) and pupil diameter (PD). In the multivariable analyses, AL reduction was negatively associated with baseline age (beta: − 0.048; 95% CI: − 0.083 to − 0.013; P = 0.009) and positively associated with the TZ (beta: 0.024; 95% CI: 0.009 to 0.040; P = 0.003). Conclusions In AL reduction eyes, thickened CLT, decreased ACD and thinned VCD were observed during Ortho-K treatment, which could be suggested as indicators for better myopia control effects in the clinic. Older baseline age and smaller TZ wearing Ortho-K were also associated with AL change. Thickened CLT may be a result of compensation for AL-reduction eyes.

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“…However, it is crucial for practitioners to consider various factors such as refractive errors, corneal shape, and the patient’s comfort in depth. 6 Prescribing a lens that does not properly fit the patient's cornea can lead to side effects such as reduced visual acuity, abnormal corneal fluorescent staining, or corneal erosion. To address these problems, follow-up interventions may be required, involving changes in the lens parameters and types and adjustments to the wearing schedule.…”

Section: Introductionmentioning

confidence: 99%

Development of a Machine-Learning–Based Tool for Overnight Orthokeratology Lens Fitting

Koo,

Kim,

Park

et al. 2024

Trans. Vis. Sci. Tech.

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Purpose Orthokeratology (ortho-K) is widely used to control myopia. Overnight ortho-K lens fitting with the selection of appropriate parameters is an important technique for achieving successful reductions in myopic refractive error. In this study, we developed a machine-learning model that could select ortho-K lens parameters at an expert level. Methods Machine-learning models were established to predict the optimal ortho-K parameters, including toric lens option (toric or non-toric), overall diameter (OAD; 10.5 or 11.0 mm), base curve (BC), return zone depth (RZD), landing zone angle (LZA), and lens sagittal depth (LensSag). The analysis included 547 eyes of 297 Korean adolescents with myopia or astigmatism. The dataset was randomly divided into training (80%, n = 437 eyes) and validation (20%, n = 110 eyes) sets at the patient level. The model was trained based on clinical ortho-K lens fitting performed by highly experienced experts and ophthalmic measurements. Results The final machine-learning models showed accuracies of 92.7% and 86.4% for predicting the toric lens option and OAD, respectively. The mean absolute errors for the BC, RZD, LZA, and LensSag predictions were 0.052 mm, 2.727 µm, 0.118°, and 5.215 µm, respectively. The machine-learning model outperformed the manufacturer's conventional initial lens selector in predicting BC and RZD. Conclusions We developed an expert-level machine-learning–based model for determining comprehensive ortho-K lens parameters. We also created a web-based application. Translational Relevance This model may provide more accurate fitting parameters for lenses than those of conventional calculations, thus reducing the need to rely on trial and error.

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Weighted Zernike defocus coefficient of treatment zone is a meaningful indicator for myopia control efficacy of Ortho-K lenses

Cited by 8 publications

References 31 publications

High myopia control is comparable between multifocal rigid gas-permeable lenses and spectacles

High myopia control is comparable between multifocal rigid gas-permeable lenses and spectacles

Long-term follow-up of changes in ocular biometric parameters in orthokeratology lens wearers with relatively large-scale axial length reduction

Development of a Machine-Learning–Based Tool for Overnight Orthokeratology Lens Fitting

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