Weitere Untersuchungen über die seuchenhafte Gehirn-Rückenmarksentzündung (Bornasche Krankheit) des Pferdes, mit besonderer Berücksichtigung des Infektionsweges und der Kerneinschlüsse

Joest, E.

doi:10.1007/bf01630501

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural infection of horses and sheep is typically sporadic and peaks in spring months; epidemics of disease are infrequent (reviewed in [50]). An olfactory route for transmission has been proposed because intranasal infection is ef®cient and the olfactory bulbs of naturally infected horses show in¯amma-tion and oedema early in the course of disease [51,52]. One outbreak in a zoo has been attributed to inadvertent inoculation of BDV during vaccine administration (Mu È ller H, personal communication).…”

Section: Hosts and Epidemiologymentioning

confidence: 98%

Borna disease virus

Jordan

Lipkin

2001

Reviews in Medical Virology

View full text Add to dashboard Cite

Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species. Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates in the nucleus of the host cell where splicing is employed for expression of a very compact genome. Epidemiological studies indicate a broad host range and geographical distribution, and some investigators have proposed that human infection may result in neuropsychiatric disorders. Experimental Borna disease in neonatal and adult rats provides an intriguing model for immune-mediated disturbances of brain development and function.

show abstract

Section: Hosts and Epidemiologymentioning

confidence: 98%

Borna disease virus

Jordan

Lipkin

2001

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…However, BDV may also replicate in the retina without exerting any overt neuronal damage [84]. The brain regions most affected by the inflammatory response are the olfactory bulb, the hippocampus, and the caudate nucleus [102]. Inflammation is moderate in the spinal cord and absent in the cerebellum [101].…”

Section: Neuropathogenesismentioning

confidence: 99%

Borna Disease Virus and the Brain

Gonzalez–Dunia

Sauder

Torre

1997

Brain Research Bulletin

View full text Add to dashboard Cite

Viruses with the ability to establish persistent infection in the central nervous system (CNS) can induce progressive neurologic disorders associated with diverse pathological manifestations. Clinical, epidemiological, and virological evidence supports the hypothesis that viruses contribute to human mental diseases whose etiology remains elusive. Therefore, the investigation of the mechanisms whereby viruses persist in the CNS and disturb normal brain function represents an area of research relevant to clinical and basic neurosciences. Borna disease virus (BDV) causes CNS disease in several vertebrate species characterized by behavioral abnormalities. Based on its unique features, BDV represents the prototype of a new virus family. BDV provides an important model for the investigation of the mechanisms and consequences of viral persistence in the CNS. The BDV paradigm is amenable to study virus-cell interactions in the CNS that can lead to neurodevelopmental abnormalities, immune-mediated damage, as well as alterations in cell differentiated functions that affect brain homeostasis. Moreover, seroepidemiological data and recent molecular studies indicate that BDV is associated with certain neuropsychiatric diseases. The potential role of BDV and of other yet to be uncovered BDV-related viruses in human mental health provides additional impetus for the investigation of this novel neurotropic infectious agent.

show abstract

Neuere Arbeiten über Encephalitiden bei Tieren

Ernst

1931

Ergebnisse Der Hygiene Bakteriologie Immunitätsforschung Und Experimentellen Therapie

View full text Add to dashboard Cite

Weitere Untersuchungen über die seuchenhafte Gehirn-Rückenmarksentzündung (Bornasche Krankheit) des Pferdes, mit besonderer Berücksichtigung des Infektionsweges und der Kerneinschlüsse

Cited by 5 publications

References 0 publications

Borna disease virus

Borna disease virus

Borna Disease Virus and the Brain

Neuere Arbeiten über Encephalitiden bei Tieren

Contact Info

Product

Resources

About