Weitere Untersuchungen zur Molekularpathologie der Entzündung: Die Exsudate

Schade, H.; Claussen, F.; Häbler, C.; Hoff, Ferdinand; Mochizucki, N.; Birner, M.

doi:10.1007/bf02622491

Cited by 49 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was again attributed to high cellular respiration of infiltrated cells and a reduced gas-exchange with the healthy tissue. In addition to that, they measured a time-dependent increase in lactate and a decrease in the bicarbonate levels, which together could explain the decrease in pH of inflamed tissue, previously observed by Schade ( 6 ). Kempner and Peschel identified metabolic changes in inflamed tissue as a function of time, which is actively established by infiltrating “injured” immune cells with an adapted cellular metabolism ( 5 ).…”

Section: Concepts Of Immunometabolismsupporting

confidence: 62%

Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway

2015

View full text Add to dashboard Cite

A process is a function of time; in immunometabolism, this is reflected by the stepwise adaptation of metabolism to sustain the bio-energetic demand of an immune-response in its various states and shades. This perspective article starts by presenting an early attempt to investigate the physiology of inflammation, in order to illustrate one of the basic concepts of immunometabolism, wherein an adapted metabolism of infiltrating immune cells affects tissue function and inflammation. We then focus on the process of macrophage activation and aim to delineate the factor time within the current molecular context of metabolic-rewiring important for adapting primary carbohydrate metabolism. In the last section, we will provide information on how the pentose phosphate pathway may be of importance to provide both nucleotide precursors and redox-equivalents, and speculate how carbon-scrambling events in the non-oxidative pentose phosphate pathway might be regulated within cells by demand. We conclude that the adapted metabolism of inflammation is specific in respect to the effector-function and appears as a well-orchestrated event, dynamic by nature, and based on a functional interplay of signaling- and metabolic-pathways.

show abstract