“…Some studies reported either no change in the patients' quality of life (de Grauw, van de Lisdonk, van Gerwen, van den Hoogen, & van Weel, 2001;UKPDS 37, 1999) or negative mood changes including problems with social functioning, greater emotional fatigue and perceived burdensomeness of the treatment (Goddjin et al, 1999;Reach, Le Pautremat, & Gupta, 2013;de Sonnaville et al, 1998), as well as increased tension, but only in patients with more frequent hypoglycemic episodes (UKPDS 37, 1999). Opposite effects were also noted, i.e.…”