Well-Differentiated Mesenteric Liposarcoma with Osseous Metaplasia: A Potential Diagnostic Dilemma for the Pathologist

Gupta, Ruchika; Sharma, Alok; Arora, Raman; Kulkarni, Mukund Prabhakar; Chattopadhaya, T. K.; Singh, Manoj Kumar

doi:10.1007/s12029-009-9119-2

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Primary WD mesenteric liposarcomas are rare with only 12 well-documented cases (including the present case) in the English literature (table 2) [10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20]. …”

Section: Discussionmentioning

confidence: 94%

Well-Differentiated Liposarcoma, an Atypical Lipomatous Tumor, of the Mesentery: A Case Report and Review of the Literature

Yuri

Miyaso²,

Kitade³

et al. 2011

Case Rep Oncol

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Mesenteric liposarcoma is a rare neoplasm. Here, we report the case of a 73-year-old Japanese man with a well-differentiated (WD) liposarcoma of the mesentery. Due to rapid growth of the abdominal mass and abdominal insufficiency, a tumorectomy was performed. The excised tumor was 12.4 × 9.6 cm in size and weighed 548 g. Cut sections showed a lobulated yellow and/or grayish-colored appearance. The histological features were predominantly those of the sclerotic and lipoma-like variants of WD liposarcoma. The cytoplasm of most spindle cells was diffusely immunoreactive for CD34, while fat cells were positive for S-100 protein. Some spindle cell nuclei were positive for CDK4, and a few were positive for MDM2. The average Ki-67 proliferation index in tumor cells was 10%, and androgen receptor expression was detected in tumor cell nuclei. The present case and 11 cases identified from a literature search were reviewed. The WD mesenteric liposarcomas developed in patients in the fourth to seventh decades of life (mean age 57.9 years). The patients consisted of 7 men and 5 women. All tumors were larger than 10 cm in diameter at the time of surgery. Complete resection might be the only curative therapy for WD liposarcomas of the mesentery, but long-term follow-up is needed because of the possibility of a local recurrence of the tumor.

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Section: Discussionmentioning

confidence: 94%

Well-Differentiated Liposarcoma, an Atypical Lipomatous Tumor, of the Mesentery: A Case Report and Review of the Literature

Yuri

Miyaso²,

Kitade³

et al. 2011

Case Rep Oncol

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“…For example, rarely, metaplastic bone formation can be seen associated with well-differentiated LPS [ 1 ] , and DDLPS not uncommonly shows metaplastic bone formation and heterologous elements, including osteosarcomatous differentiation [ 3 , 14–16 ] . Ossification in the soft tissues without surrounding fatty tissue should also raise concern for extraskeletal osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…The histologic appearances of DDLPS vary greatly, ranging from a relatively uniform spindle cell morphology to a highly pleomorphic undifferentiated appearance. Certain patterns, including a meningothelial-like whorling pattern of dedifferentiation, have been recently linked to bone formation within DDLPS in some cases [ 1 , 3 , 4 , 14–16 ] . Our case is rare in that it demonstrates extensive metaplastic ossification within an ALT/WDLPS not associated with meningothelial-like, osteosarcomatous, or other types of dedifferentiated tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Metaplastic ossification within atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a rare occurrence [ 1 ] , and when present is often associated with a dedifferentiated component [ 2–4 ] . We report the radiologic and pathologic features of a rare case of ALT/WDLPS with extensive metaplastic ossification, however without an element of dedifferentiated liposarcoma (DDLPS).…”

Section: Introductionmentioning

confidence: 99%

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Atypical lipomatous tumor with unusual extensive metaplastic ossification

et al. 2012

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The presence of metaplastic ossification within atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a rare occurrence. When present, bone formation is most often found in association with a dedifferentiated component arising within the primary tumor. It is important for the radiologist not only to recognize the differential diagnosis of a calcified or ossified soft tissue mass but also be aware of the various soft tissue neoplasms, both aggressive and non-aggressive, that may show such features. We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma.

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“…The presence of metaplastic ossification within an ALT is a rare occurrence. 1 We report a case of ALT with unusual extensive metaplastic bone formation. Case summary A 30 year old female presented with swelling in the right upper arm for the past one and a half years.…”

Section: Introductionmentioning

confidence: 93%