Well-ordered mesoporous silica and bioactive glasses: promise for improved hemostasis

Pourshahrestani, Sara; Kadri, Nahrizul Adib; Zeimaran, Ehsan; Towler, Mark R.

doi:10.1039/c8bm01041b

Cited by 86 publications

(101 citation statements)

References 93 publications

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“…Thrombogenicity estimation was followed according to Imai and Nose (1972) and Ostomel, Shi, Tsung, Liang, and Stucky (2006). Previous reports elucidated the considerable hemostatic behavior of bioactive glass (Ostomel et al, 2006; Pourshahrestani, Kadri, Zeimaran, & Towler, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…Baino, Fiume, Miola, and Verne (2018) also well agreed with our previous report (Chitra et al, 2019) by explaining the calcium essentiality in apatite precipitation and Hydroxycarbonate Apatite (HCA) role in new bone matrix formation. Some reports (Ostomel et al, 2006; Pourshahrestani et al, 2017; Pourshahrestani et al, 2018; Pourshahrestani et al, 2019) are available to explain the hemostatic activity of bioactive materials. Pourshahrestani et al (2018) investigated the hemostatic behavior of gallium bioglass (Ga‐MBG) and compared with commercial hemostats (CX and ACS + ) and further explained that bioglass has superior formation of thrombus.…”

Section: Discussionmentioning

confidence: 99%

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Thermal treatment stimulus on erythrocyte compatibility and hemostatic behavior of one‐dimensional bioactive nanostructures

Chitra

Bargavi

et al. 2020

J Biomedical Materials Res

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This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step annealed at 550 and 600°C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle‐like and rod‐like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO4, Na2Ca2Si3O9, and Na1.8Ca1.1Si6O14 were observed for all the bioactive materials, whereas in the case of 800°C, phase transition of Na3CaPSiO7 was perceived along with P2O5. Alternatively, morphology varied from cubical (600°C) to rod‐like (step annealing) and further turned toward flake‐like (800°C) structures. Step‐annealing process decomposed the nitrate groups as well as maintained the glass network without altering the crystalline phases. As a result, bioactive nanomaterials subjected to step annealing at 550°C along with 600°C exhibited superior compatibility with erythrocytes. Bioglass heat treated at 800°C revealed incredible blood clotting efficacy, in which Ca2+ ions initiated the thrombotic effect, blood components were concentrated due to the effect of calcium, and enhances the hemostatic performance. Bioactive glass annealed below 800°C facilitates the biocompatibility, subsequently encourage bone ingrowths at in vivo. Bioglass‐800°C inspired the fibrin formation and induced clot as a hemostat to control hemorrhage.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Thermal treatment stimulus on erythrocyte compatibility and hemostatic behavior of one‐dimensional bioactive nanostructures

Chitra

Bargavi

et al. 2020

J Biomedical Materials Res

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“…In recent years, the development of multifunctional antibacterial materials with hemostasis and wound‐healing capabilities has attracted increasing attention in the field of biomaterials . The chlorhexidine diacetate (CHX)‐loaded nanogels (CLN) were first prepared via enzyme degradation procedure, and the obtained CLNs were mixed with precursors of aminoethyl methacrylate hyaluronic acid (HA‐AEMA) and methacrylated methoxy polyethylene glycol (mPEG‐MA) for photoinduced cross‐linking ( Figure a) .…”

Section: Biodegradable Polymeric Nanosystems Containing Antibioticsmentioning

confidence: 99%

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Ding

Wang

Tong

2019

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159

108

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Figure 17. a) Schematic illustration for the fabrication of chlorhexidine diacetate (CHX)-loaded antibacterial nanogels for hemostasis and wound healing applications. b) Wound healing processes after treated with different materials. Reproduced with permission. [109] Figure 25. a) Schematic illustration, b) synthetic route, and c) TEM images of phosphonium-functionalized polymer micelles. Reproduced with permission. [126]

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“…Initially mostly used for bone repair due to its unique biomineralization upon implantation, nanoparticulate bioglass and its variations have recently shown great promise in soft tissue wound healing [ 79 ]. Apart from its tissue bonding and hemostatic properties [ 80 , 81 ], some modifications, such as strontium-substitution [ 82 ], have been shown to accelerate cell proliferation and angiogenesis. Furthermore, several borate-based formulations have enhanced wound closure and human cell proliferation.…”

Section: Metal Oxide Nanoparticle Hybrid Materialsmentioning

confidence: 99%

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

2020

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Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

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Well-ordered mesoporous silica and bioactive glasses: promise for improved hemostasis

Abstract: Mesoporous silica and bioactive glasses with unique textural properties are new generations of inorganic hemostats with efficient hemostatic ability.

Cited by 86 publications

References 93 publications

Thermal treatment stimulus on erythrocyte compatibility and hemostatic behavior of one‐dimensional bioactive nanostructures

Thermal treatment stimulus on erythrocyte compatibility and hemostatic behavior of one‐dimensional bioactive nanostructures

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

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