Well Water Arsenic Exposure, Arsenic Induced Skin-Lesions and Self-Reported Morbidity in Inner Mongolia

Xia, Yanfei; Tj, Wade; Wu, Kegong; Y, Li; Ning, Zhixiong; Le, X. Chris; He, X. T.; B, Chen; Feng, Yongsheng; Mumford, JL

doi:10.3390/ijerph6031010

Cited by 55 publications

(50 citation statements)

References 40 publications

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“…These dermal effects have been noted in a large majority of human studies involving repeated oral exposure via arsenic-contaminated drinking water. Studies in Bangladesh (Ahsan et al, 2000Rahman et al, 2006a;McDonald et al, 2007), India (Guha Mazumder et al, 1998;Haque et al, 2003), Inner Mongolia Li et al, 1994;Luo et al, 1994;Sun et al, 1994;Yoshida et al, 2004;Guo et al, 2006;Xia et al, 2009) and Pakistan (Fatmi et al 2009;Kazi et al, 2009) reported increased incidences of skin lesions associated with arsenic concentrations in drinking water <100 µg/L.…”

Section: Skin Lesionsmentioning

confidence: 99%

“…The BMD analysis is described in detail in Appendix showing also the risk BMC 01 and BMCL 01 values obtained with slope restriction where however none of the models was acceptable. 9 92 (a): Dose deliberately set to 400 µg/L for the largest interval >300 µg/L, used in Table 2 in Xia et al (2009) 8.4.1.3. Skin cancer (Table 33) Previous assessments, such as that of WHO/IPCS (1981), based their skin cancer risk estimates on the data of Tseng et al (1968), Tseng (1977 with extrapolation to lower levels of exposure.…”

Section: Inorganic Arsenicmentioning

confidence: 99%

“…The US EPA's benchmark dose software software (BMDS) version 2.0 was used (US EPA, 2008) 31 for modelling the incidence of skin lesions in the following three human studies on dermal lesions (see Table 36): Ahsan et al (2006), Bangladesh, cross sectional study Rahman et al (2006a), Bangladesh, case referent study Xia et al (2009), Mongolia, case control study…”

Section: Appendix a Benchmark Dose Modelling Of Dermal Lesionsmentioning

confidence: 99%

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Scientific Opinion on Arsenic in Food

2009

EFSA Journal

877

220

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The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

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Section: Skin Lesionsmentioning

confidence: 99%

Section: Inorganic Arsenicmentioning

confidence: 99%

Section: Appendix a Benchmark Dose Modelling Of Dermal Lesionsmentioning

confidence: 99%

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Scientific Opinion on Arsenic in Food

2009

EFSA Journal

877

220

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“…The International Agency for Research on Cancer (IARC) has classified As in water as a cause of human cancer (IARC, 2002;Dauphiné et al, 2013). The types of cancer associated with exposure to As via water are liver, kidney, skin, lung, and colon cancers (Xia et al, 2009;Dauphiné et al, 2013;Mostafa and Cherry, 2015). Bangladesh, India, Taiwan, Argentina, Chile, China, Hungary, Japan, Mongolia, Poland, the United States, Canada, Nepal, Vietnam, Italy, Finland, Spain, New Zealand, and Mexico are the countries that have reported As contamination in water (Islam et al, 2004;Hoque and Butler, 2015).…”

Section: Introductionmentioning

confidence: 99%

Detection of damage on single- or double-stranded DNA in a population exposed to arsenic in drinking water

et al. 2017

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ABSTRACT. Different studies have suggested an association between arsenic (As) exposure and damage to single-stranded DNA by reactive oxygen species derived from the biotransformation of arsenic. The single strand damages are converted to double strand damage upon interaction with ultraviolet radiation. Analysis of genomic integrity is important for assessing the genotoxicity caused by environmental pollutants. In this study, we compared the concentration of As in drinking water, nutritional status, lifestyle variables, and the level of genotoxicity in an exposed population and a control group. Arsenic content of water was determined using a portable Arsenator ® kit. DNA fragmentation was determined using the two-tailed comet assay. Our results show that 2 J. Jiménez-Villarreal et al.Genetics and Molecular Research 16 (2): gmr16029241 the exposed population had low nutritional consumption compared to the control group (P < 0.05). Furthermore, the water consumed by the exposed group had As concentration of 14.3 ± 8.4 mg/L, whereas the As level in the water consumed by the control group was 7.7 ± 3.5 mg/L. Analysis shows that the frequency of double strand break (DSB) fragmentation was higher in the population exposed to higher levels of As compared to that of the control group. These results suggest a possible association between the concentration of As in drinking water and lifestyle variables, with increasing fragmentation of DSBs in the exposed population.

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“…High levels of arsenic in groundwater is attributed to oxidative dissolution of arsenic-rich pyrite or arsenopyrite (Mandal et al 1998; Chowdhury et al 1999), reductive dissolution of arsenic-rich iron oxyhydroxides (Acharyya et al 1999; Nickson et al 2000), and water-rock reaction with arsenic bearing minerals (Smedley et al 1996;Nimick 1998). Arsenic contamination in groundwater is a very serious concern as its chronic exposure may lead to skin cancer (Bunnell et al 2007), cardiovascular and peripheral vascular diseases (Xia et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Groundwater recharge influencing the arsenic enrichment in the aquifer of west Bengal

Sen

Vishwakarma

Asthana

et al. 2016

IJAG

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Arsenic contamination, a very serious issue, has a detrimental effect on the living being. Arsenic contamination is found in the Gangetic plains, with West Bengal as the most affected state. In the present study, an attempt has been made to use weighted overlay analysis for arsenic hazard zonation based on the factors that influence the groundwater in a terrain. Weighted overlay analysis was done for mapping the arsenic contamination zone by assigning weightage and rating to geomorphology, land use/land cover, soil type, cropping intensity, slope and drainage density in North 24 Parganas. The whole region has been formed by the sedimentation from the river, and soil at the surface contains higher concentration of arsenic. Arsenic may get released from the sediment by various mechanism and transport downward along with the infiltration of rainwater. Thus, arsenic contamination in groundwater is influenced by the arsenic rich sediments, slope, and drainage pattern of the area. The arsenic concentration in collected groundwater samples shows the same result as obtained from the weighted overlay analysis except in the area with deeper water level. Thus, weighted overlay analysis along with water level data can be an effective method for determining the risk of arsenic in an area.

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Well Water Arsenic Exposure, Arsenic Induced Skin-Lesions and Self-Reported Morbidity in Inner Mongolia

Cited by 55 publications

References 40 publications

Scientific Opinion on Arsenic in Food

Scientific Opinion on Arsenic in Food

Detection of damage on single- or double-stranded DNA in a population exposed to arsenic in drinking water

Groundwater recharge influencing the arsenic enrichment in the aquifer of west Bengal

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