Wernicke's encephalopathy in non-alcoholics

Lindboe, Christian Fredrik; Løberg, Else Marit

doi:10.1016/0022-510x(89)90095-6

Cited by 79 publications

(32 citation statements)

References 11 publications

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“…Adult necroscopy studies have revealed a worldwide incidence ranging from 0.5% in Norway to 2.8% in Australia. 2,[20][21][22][23] The incidence observed in adults is approximately equal to that observed in children. …”

Section: Discussionmentioning

confidence: 66%

MR Imaging Findings in 56 Patients with Wernicke Encephalopathy: Nonalcoholics May Differ from Alcoholics

Zuccoli¹,

Cruz²,

Bertolini³

et al. 2008

AJNR Am J Neuroradiol

241

157

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Section: Discussionmentioning

confidence: 66%

MR Imaging Findings in 56 Patients with Wernicke Encephalopathy: Nonalcoholics May Differ from Alcoholics

Zuccoli¹,

Cruz²,

Bertolini³

et al. 2008

AJNR Am J Neuroradiol

241

157

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“…Many clinic-pathological studies indicated that in approximately 80% cases, the diagnosis of WE could not be done during life [12,13]. Similarly, substantial time delays had been reported since WE was misdiagnosed with a psychiatric disease [14].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Wernicke's encephalopathy in a 16year-old girl with atypical clinical and radiological features

Lamdhade

Al-Mulla

Alroughani

2013

Journal of the Neurological Sciences

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Background. Wernicke's Encephalopathy (WE) is a clinical diagnosis with serious neurological consequences. Its occurrence is underestimated in nonalcoholics and is uncommon in adolescents. We aim to draw the attention to a rare case, which had additional clinical and radiological features. Case. A 16-year-old girl presented with three-week history of vomiting secondary to intestinal obstruction. She developed diplopia soon after hospitalization. Neurological evaluation revealed restriction of bilateral lateral recti with horizontal nystagmus, and bilateral limb dysmetria. Brain MRI was normal. She had prompt improvement to thiamine. Four months later, she presented with headache, bilateral severe deafness, and tinnitus. Clinically, she had severe sensorineural hearing loss, bilateral lateral recti paresis, and gait ataxia. CT head showed bilateral caudate nucleus hypodensities. MRI brain revealed gadolinium enhancement of mamillary bodies and vermis. She had significant improvement after IV thiamine. Headache completely resolved while the ocular movements, hearing, and tinnitus improved partially in 72 hours. Conclusions. Recurrent WE in adolescence is uncommon. Headache, tinnitus, and deafness are rare clinical features. Although MRI study shows typical features of WE, the presence of bilateral caudate nuclei hypodensities on CT scan is uncommon. Prompt treatment with thiamine is warranted in suspected cases to prevent permanent neurological sequelae.

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“…Although WE is thought to occur mainly in the alcoholic population due to poor nutritional habits, Lindboe's autopsy series of 6,964 autopsies in Norway demonstrated WE in 12 of 52 patients (23%) nonalcoholic patients. 27 Among the 18 cases with clinical WE disease, all of them were diagnosed in patients with alcoholism. The most common clinical symptoms were depressed levels of consciousness and disorientation, whereas only 3 cases noted eye symptoms.…”

Section: Discussionmentioning

confidence: 99%

Wernicke's Encephalopathy in a Patient with Schizophrenia

Harrison

Hunter

2006

J Gen Intern Med

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Clinically, we most often associate Wernicke's encephalopathy (WE) with an alcohol abusing population. However, it is important to consider other causes of malnutrition and vitamin deficiency as risk factors for the development of this disorder. We present a case of a 51‐year‐old man with schizophrenia and malnutrition who presented with delirium, ophthalmoplegia, and seizures. He responded rapidly to the administration of IV thiamine. Because of the high rate of mortality and morbidity, WE should be high on the differential of any patient at risk for malnutrition or with ophthalmoplegia, regardless of alcohol history. This is particularly important in psychiatric patients where the syndrome may be masked and thus treatment delayed.

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Wernicke's encephalopathy in non-alcoholics

Cited by 79 publications

References 11 publications

MR Imaging Findings in 56 Patients with Wernicke Encephalopathy: Nonalcoholics May Differ from Alcoholics

MR Imaging Findings in 56 Patients with Wernicke Encephalopathy: Nonalcoholics May Differ from Alcoholics

Recurrent Wernicke's encephalopathy in a 16year-old girl with atypical clinical and radiological features

Wernicke's Encephalopathy in a Patient with Schizophrenia

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