West Nile Virus Seroprevalence Among Blood Donors in Hungary

Nagy, Anna; Szöllősi, Tímea; Takács, Mária; Magyar, Nóra; Barabás, Éva

doi:10.1089/vbz.2018.2401

Cited by 8 publications

(10 citation statements)

References 23 publications

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“…Similar WNV prevalence studies performed in other European countries and in the Mediterranean Basin detected neutralizing antibodies in 1.5% and 2.34% of the population in Greece [26] and in Hungary [27], respectively, while the results of this study are more in line with the prevalence observed in Bulgaria [28].…”

Section: Discussionsupporting

confidence: 91%

West Nile Virus Seroprevalence in the Italian Tuscany Region from 2016 to 2019

et al. 2021

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Although in humans West Nile virus is mainly the cause of mild or sub-clinical infections, in some cases a neuroinvasive disease may occur predominantly in the elderly. In Italy, several cases of West Nile virus infection are reported every year. Tuscany was the first Italian region where the virus was identified; however, to date only two cases of infection have been reported in humans. This study aimed at evaluating the prevalence of antibodies against West Nile virus in the area of Siena Province to estimate the recent circulation of the virus. Human serum samples collected in Siena between 2016 and 2019 were tested for the presence of antibodies against West Nile virus by ELISA. ELISA positive samples were further evaluated using immunofluorescence, micro neutralization, and plaque reduction neutralization assays. In total, 1.9% (95% CI 1.2–3.1) and 1.4% (95% CI 0.8–2.4) of samples collected in 2016–2017 were positive by ELISA and immunofluorescence assay, respectively. Neutralizing antibodies were found in 0.7% (95% CI 0.3–1.5) of samples. Additionally, 0.9% (95% CI 0.4–1.7) and 0.65% (95% CI 0.3–1.45) of samples collected in 2018–2019 were positive by ELISA and immunofluorescence assay, respectively. The prevalence of neutralizing antibodies was 0.5% (95% CI 0.2–1.3). Although no human cases of West Nile infection were reported in the area between 2016 and 2019 and virus prevalence in the area of Siena Province was as low as less than 1%, the active asymptomatic circulation confirms the potential concern of this emergent virus for human health.

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Section: Discussionsupporting

confidence: 91%

West Nile Virus Seroprevalence in the Italian Tuscany Region from 2016 to 2019

et al. 2021

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“…Concerning the prevalence of WNV IgG antibody, the results of the present study are in line with many studies conducted in other countries, especially in the Middle East and other parts of the world such as Libya, Algeria, Northern Cyprus, Bolivia, Hungary, Greece and Jordan, as well as in studies carried out in Iran, in which the prevalence of the aforementioned antibody ranged from 2.34% to 8.61% [5,[17][18][19][20][21][22][23][24][25].…”

Section: Discussionsupporting

confidence: 90%

Seroprevalence of West Nile Virus in Regular Blood Donors Referred to the Blood Bank of Kurdistan Province, Iran

Babahajian

Sharifi

Babahajiani³

et al. 2022

SJMS

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Background: West Nile virus is an infection that is most commonly caused by infected mosquito bites, however, blood transfusions, organ transplants, breast feeding, pregnant mother-to-the-fetus transmission, and occupational transmission among laboratory and medical staff are also the less common routes of infection. Given the endemic nature of this virus in the Middle East, the aim of this study was to investigate the presence of this virus in regular blood donors, as the reliable source of blood supply needed for patients in hospitals. Methods: In this descriptive-analytical study, venous blood samples were collected from 259 regular blood donors referred to the Blood Transfusion Organization of Kurdistan. After separating blood serum, the amount of IgM and IgG antibodies against West Nile virus was measured via ELISA test. Results: Concerning antibodies, IgG and IgM against West Nile virus were positive in 14 patients (5.4%) and 3 patients (1.2%), respectively. Seropositive IgG levels were observed in 11 patients over the age of 40 (12.5%) but only in 3 patients under 40 years of age (1.8%). The difference was statistically significant (OR = 7.95; 95% CI: 2.16–29.32; p < 0.01). Conclusion: Given the value of blood and blood products obtained from regular blood donors for therapeutic purposes and the significant prevalence of the virus and considering the presence of cases with positive IgM, it seems necessary to screen blood donors in blood transfusion centers in the western parts of Iran.

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“…In each case, we attempted to characterise the virus using peripheral blood leukocytes or brain and spinal cord samples by virus isolation, nested reverse transcriptase polymerase chain reaction (RT-PCR), real-time RT-PCR and sequencing techniques, as described previously (Kutasi et al, 2011). The virus neutralisation (VN) test was run in 9 of 13 WNND cases and on all control CSF samples as described by Nagy et al (2019).…”

Section: Methodsmentioning

confidence: 99%

Characterisation of the cerebrospinal fluid of horses with West Nile virus neuroinvasive disease

Kutasi

Fehér

Sárdi

et al. 2020

AVet

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West Nile virus (WNV) is a zoonotic arbovirus transmitted by mosquitoes between wild birds (natural hosts) and other vertebrates. Horses and humans are incidental, dead-end hosts, but can develop severe neurological disorders. Owing to the close contact of cerebrospinal fluid (CSF) with the extracellular fluid of the brain, the analysis of CSF composition can reflect central nervous system (CNS) impairments enabling the diagnosis and understanding of various neurodegenerative CNS disorders. Our objective was to compare the findings from the CSF samples of horses with neuroinvasive WNV infection with those of healthy controls. We compared findings from fifteen CSF samples of 13 horses with acute WNV encephalomyelitis with those of 20 healthy controls. Protein, particular enzymes and ions, glucose and lactate showed abnormal levels in a significant number of WNV cases. None of the six horses with elevated glucose concentrations survived. Rather neutrophilic than mononuclear pleocytosis was identified with WNV infection. Neutrophils probably play a role in the development of inflammatory response and brain damage. Although elevated glucose levels reliably predicted the outcome, they might be the consequence of increased plasma levels and reflect general stress rather than CNS pathophysiology. The CSF findings of WNV encephalomyelitis patients are non-specific and variable but facilitate the differential diagnosis.

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West Nile Virus Seroprevalence Among Blood Donors in Hungary

Cited by 8 publications

References 23 publications

West Nile Virus Seroprevalence in the Italian Tuscany Region from 2016 to 2019

West Nile Virus Seroprevalence in the Italian Tuscany Region from 2016 to 2019

Seroprevalence of West Nile Virus in Regular Blood Donors Referred to the Blood Bank of Kurdistan Province, Iran

Characterisation of the cerebrospinal fluid of horses with West Nile virus neuroinvasive disease

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