The Illinois River Valley (IRV) in central Illinois, USA, provides migratory stopover habitat for millions of waterfowl during autumn and spring in the Mississippi Flyway. Mallards (Anas platyrhynchos) are the most abundant species of waterfowl during autumn migration and the most harvested duck in Illinois. We investigated mallard migration ecology in central Illinois, USA, to address information needs of biologists and managers in the Upper Mississippi River and Great Lake Region Joint Venture and Illinois Department of Natural Resources. Our objectives were to document daily movements and identify factors affecting interwetland movements, investigate lengths of foraging flights, assess home range size during stopover, describe habitat use and identify factors associated with wetland use, estimate survival and cause specific mortality, and evaluate proportional use of refuges and areas open to hunting in and nearby the IRV by mallards. We employed standard radio-telemetry techniques to achieve our objectives during autumns and early winters 2009 and 2010 (n ¼ 86 F and 56 M mallards). The mean movement distance between locations collected on consecutive days was 2,822 AE 120 (SE) m (n ¼ 1,862; max. ¼ 56,966 m) across age, sex, and months. Female mallards (n ¼ 35) traveled 2,708 AE 191 m during evening foraging flights (n ¼ 145) to agricultural fields and emergent marshes. Mean home range size (95% minimum convex polygon) was 21,306 AE 1,925 ha across sex and age classes (n ¼ 81 mallards). We documented 43 mortalities of 142 radio-marked mallards (2009: 28.2%; 2010: 32.3%) with 85.0% and 69.6% of deaths attributed to hunting in 2009 and 2010, respectively. Body condition, hunting period, age, year, minimum daily temperature, and daily movement distance were important variables affecting survival, but differences were most pronounced for year and hunting period.